Investigating the effects of macrolides on excessive synthesis and secretion of airway mucins using novel ex vivo and in vivo approaches

使用新颖的离体和体内方法研究大环内酯类药物对气道粘蛋白过度合成和分泌的影响

• 批准号: nhmrc : 1143496
• 负责人: A/Pr Alexander Larcombe
• 金额: $ 35.21万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-effects-macrolides-vivo-approaches/1319968
• 关键词: Investigating; effects; macrolides; excessive; synthesis

Many people have difficulty breathing because the airway tubes that move air in and out of their lungs are blocked by excessive amounts of sticky mucus. Our project will use new techniques developed in our laboratories to investigate whether a group of medicines called “macrolides” can prevent the excessive production and release of mucus in the airways, and thus be beneficial in treating asthma, and potentially other lung diseases.

许多人呼吸困难，因为将空气进出的气道管被过量的粘液粘液阻塞。我们的项目将使用我们的实验室开发的新技术来研究一组称为“大环内酯类药物”的药物是否可以防止气道中的粘液过量产生和释放，从而有益于治疗哮喘，以及潜在的其他肺部疾病。