Program for HIV Prevention and Treatment-Clinical Trial Unit, Thailand

泰国艾滋病毒预防和治疗计划临床试验中心

• 批准号: 8865791
• 负责人: Gonzague Joseph Jourdain
• 金额: $ 20.49万
• 依托单位: INSTITUTE OF RESEARCH AND DEVELOPMENT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8865791
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adult; Affect; Anti-Retroviral Agents; Area; Child; Clinical Research; Clinical Trials; Clinical Trials Unit; Collaborations; Communities; Environment; Guidelines; HIV; HIV Infections; Health Personnel; Healthcare Systems; Hospitals; IMPAACT; International; Knowledge; Leadership; Methods; Mission; Monitor; Patients; Population; Public Health; Public Hospitals; Research; Research Activity; Research Infrastructure; Research Personnel; Site; Structure; Thailand; Vertical Disease Transmission; base; caregiving; clinical research site; cohort; follow-up; improved; prevent; programs; scale up; treatment program

DESCRIPTION (provided by applicant): The PHPT research group was created in 1996 in Thailand, with the mission to develop strategies for preventing mother-to-child transmission of HIV, and methods of treating AIDS that could be integrated in the existing health care system in order to reach the populations who needed it most. The collaboration between the clinical trial unit, 37 public hospitals and the Ministry of public Health resulted in the completion of two major PMTCT studies that form the basis of the WHO and Thai national guidelines on PMTCT. Following previous collaboration with PACTG, the PHPT-CTU will continue to address outstanding issues that have been targeted by the IMPAACT leadership network. Within the context of rapid scale up of antiretroviral treatment programs in Thailand, PHPT has started a treatment monitoring strategy trial (PHPT-3) and organized a structured follow up of a large cohort of patients on treatment, and strengthened the involvement of the communities in these research activities. Therefore another area of focus for the PHPT CTU will be optimization of treatments in adults and adolescents. The organization of PHPT has demonstrated its ability to successfully conduct large clinical trials. The PHPT group has selected the 10 strongest clinical research sites to implement international studies with the leadership networks. These sites have access to large affected populations and have the expertise and infrastructure to carryout these studies, as well as contributing to the research agenda of the networks. The participation in the networks will add to the existing international collaborations to provide an environment conducive to the promotion of new investigators and clinical research staff in Thailand to sustain HIV research efforts. The research agenda to which the PHPT-CTU intends to contribute will have a major public health impact not only in Thailand but also for all communities affected by HIV. The sites participating in this research are Bhumibol Adulyadej Hospital, Chonburi Hospital, Hat Yai Hospital, Maharaj Nakorriratchasrima Hospital, Nakhonpathom Hospital, Nakornping Hospital, Phayao Provincial Hospital, Drapokklao Hospital, Samutprakarn Hospital, and Samutsakorn Hospital. This research aims to develop more effective ways of preventing HIV infection in children and to improve methods to treat HIV infected adults, adolescents and children. It will also strengthen the expertise of the health care workers participating in the research in Thailand, and the knowledge produced will improve the care given in all affected areas. ADMINISTRATIVE COMPONENT:

描述（由申请人提供）：PHPT研究小组于1996年在泰国成立，其使命是制定防止母亲到孩子传播艾滋病毒的策略，以及可以在现有医疗保健系统中整合的治疗艾滋病的方法为了达到最需要它的人群。临床试验部门，37家公立医院和公共卫生部之间的合作完成了两项主要的PMTCT研究，构成了WHO和泰国国家PMTCT国家准则的基础。在先前与PACTG合作之后，PHPT-CTU将继续解决Incract领导网络针对的杰出问题。在泰国抗逆转录病毒治疗计划的快速规模的背景下，PHPT已开始了一项治疗监测策略试验（PHPT-3），并组织了大量患者进行治疗的结构性随访，并加强了社区参与。这些研究活动。因此，PHPT CTU的另一个重点领域将是对成年人和青少年的治疗的优化。 PHPT的组织表明了其成功进行大型临床试验的能力。 PHPT小组选择了10个最强的临床研究网站来通过领导网络实施国际研究。这些站点可以访问大量受影响的人群，并具有进行这些研究的专业知识和基础设施，并为网络的研究议程做出了贡献。参与网络将增加现有的国际合作，以提供有利于促进泰国新调查人员和临床研究人员的环境，以维持HIV研究工作。 PHPT-CTU打算做出贡献的研究议程将不仅在泰国产生重大的公共卫生影响，而且对所有受艾滋病毒影响的社区产生了重大影响。参与这项研究的站点是Bhumibol Adulyadej医院，Chonburi医院，Hat Yai医院，Maharaj Nakorriratchasrima医院，Nakhonpathom医院，Nakornpathing医院，Nakornpathing医院，Phayao省医院，Drapokkklao医院，Samutprakarn医院，Samutprakarn Hospital，Samutsakarn Hospital，samutsakarn Hospital。 这项研究旨在开发更有效的方法来预防儿童的艾滋病毒感染，并改善治疗艾滋病毒感染的成年人，青少年和儿童的方法。它还将加强参与泰国研究的卫生保健工作者的专业知识，而所产生的知识将改善所有受影响地区的护理。 管理组件：