MULTI-PHYSICS LAYER

多物理层

• 批准号: 8362506
• 负责人: JAMES Choate SCHAFF
• 金额: $ 3.16万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362506
• 关键词: Architecture; Biological Process; Cells; Chemicals; Devices; Drug Formulations; Equation; Funding; Future; Grant; Laws; Maps; Mathematics; Measurement; Modeling; National Center for Research Resources; Physiological; Principal Investigator; Process; Research; Research Infrastructure; Resources; Semantics; Source; Specific qualifier value; System; Time; Translations; United States National Institutes of Health; cost; flexibility; mathematical model; operation; physical model; research study; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In order to support the required flexibility and future extensibility of our generalized PSE architecture, an additional physical modeling layer will be introduced. The current Virtual Cell features a direct transformation from a domain-specific quantitative process description (the physiological model consisting of chemical, electrophysiological, and transport mechanisms) and user specified assumptions directly to a purely mathematical model. Implicit in this transformation from biological processes to mathematics are the choice of specific physical approximations, geometric mappings, time scales, and the underlying physical laws. The addition of additional modeling domains as well as explicit models of measurement devices (e.g. virtual experiments) call out for an intermediate physical layer where all processes (and equations) are explicit, but still map one-to-one with the process descriptions. The translation from interconnected "physical devices" to solvable systems of equations is then isolated from the formulation of a physically consistent model. Embedded in this layer are the semantics of physical consistency along with those of mathematical consistency. We will define the semantics and operations of this physical layer and provide a reference implementation (allowing for alternate representations such as CellML and Modelica). The specification of this layer provides room for specialized and sophisticated mathematical transformations to transform the physical/mathematical systems into a solvable form.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 为了支持我们的通用 PSE 架构所需的灵活性和未来的可扩展性，将引入额外的物理建模层。 当前的虚拟细胞的特点是从特定领域的定量过程描述（由化学、电生理和传输机制组成的生理模型）和用户指定的假设直接转换为纯数学模型。 从生物过程到数学的转变隐含着特定物理近似、几何映射、时间尺度和基本物理定律的选择。 添加额外的建模域以及测量设备的显式模型（例如虚拟实验）需要一个中间物理层，其中所有过程（和方程）都是显式的，但仍然与过程描述一对一映射。 然后，从互连的“物理设备”到可解方程组的转换与物理一致模型的公式分离。 这一层嵌入了物理一致性和数学一致性的语义。 我们将定义该物理层的语义和操作，并提供参考实现（允许替代表示，例如 CellML 和 Modelica）。 该层的规范为专门和复杂的数学转换提供了空间，以将物理/数学系统转换为可解的形式。