Developing a Lung Cancer Screening Registry in a State with a High Smoking Rate

在吸烟率高的州建立肺癌筛查登记处

基本信息

批准号：
8637321
负责人：
Louise Henderson
金额：
$ 19.84万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8637321
关键词：
Academic Medical Centers Adopted Adoption American Area Breast Cancer Control Cancer Detection Characteristics Chest Clinical Cohort Studies Collection Colon Carcinoma Colorectal Communities Community Practice Cost Effectiveness Analysis Data Data Collection Data Element Development Diagnostic Diagnostic radiologic examination Diffuse Diffusion Disease Dose Early Diagnosis Elements Enrollment Future General Population Goals Guidelines Health Services Accessibility Hospitals Image Incidence Knowledge Lead Lung Malignant neoplasm of lung Malignant neoplasm of prostate Measures Medical center Methods Mission Monitor Network-based North Carolina Outcome Ovarian Pathology Patients Performance Phase Pilot Projects Policies Population Population Heterogeneity Population-Based Registry Prostate Public Health Radiology Specialty Randomized Controlled Trials Recommendation Rectal Cancer Registries Reporting Research Research Personnel Research Project Grants Resources Risk Risk Factors Screening for cancer Secure Signs and Symptoms Site Smoker Smoking Staging Survey Methodology Surveys System Technology Testing Thoracic Radiography Universities Work X-Ray Computed Tomography base clinically relevant community setting development policy evidence base evidence based guidelines experience high risk innovation knowledge of results lung cancer screening malignant breast neoplasm mortality new technology population based programs prospective public health relevance radiologist screening skills tool

项目摘要

DESCRIPTION (provided by applicant): There is a gap in our knowledge of how the results of the National Lung Screening Trial (NLST) will impact the use of low dose computed tomography (LDCT) for lung cancer screening in the general population. Given the high incidence and mortality rates of lung cancer, developing evidence on the utility of a screening test that can reduce lung cancer mortality will likely lead to a significant improvement in public health. The long-term goal is to examine the delivery and quality of lung cancer screening across the U.S. by creating a prospective population based registry that captures patient, radiologist, and outcome information on the use of LDCT for screening. The objective of this application is to pilot test a population based lung cancer screening registry and determine the extent to which lung cancer screening with LDCT has diffused across the state. We plan to accomplish these objectives by pursuing the following two specific aims: (1) Develop and implement the tools required to establish a population-based lung cancer screening registry; and (2) Examine the availability of lung cancer screening with LDCT among radiology practices in the state. The study will focus on developing and implementing data collection elements as well as constructing a secure data entry system for capturing screening information from patients and radiologists. By conducting a survey of CT accredited radiology facilities we will investigate the characteristics o facilities currently performing screening in the state and also identify facilities for partnershipin the subsequent expansion phase. Currently, recommendations for LDCT for lung cancer screening are mixed, yet there is a growing need to monitor the screening experience as academic centers and community practices begin to adopt this technology for early detection in high-risk groups. This is an innovative pilot study that uses established methods in population based registry development and survey methodology to explore an emerging clinically relevant cancer screening area which is widely debated. The proposed research is significant because it will provide preliminary data on the use of LDCT for lung cancer screening in the non-clinical trial population and will also create a system for ongoing data capture that will inform the delivery and quality of lung cancer screening as this technology diffuses into the community.

描述（由申请人提供）：我们了解国家肺筛查试验（NLST）的结果存在差距，将影响使用低剂量计算机断层扫描（LDCT）进行一般人群中的肺癌筛查。鉴于肺癌的发病率和死亡率很高，因此为筛查测试的实用性提供了可以降低肺癌死亡率的效用的证据，可能会导致公共卫生的显着改善。长期的目标是通过创建一个基于人群的前瞻性注册表来检查整个美国的肺癌筛查的交付和质量，该注册表可捕获有关使用LDCT进行筛查的患者，放射科医生和结果信息。该应用的目的是试点测试基于人群的肺癌筛查注册中心，并确定LDCT肺癌筛查的程度已在整个州范围扩散。我们计划通过追求以下两个具体目标来实现这些目标：（1）开发和实施建立基于人群的肺癌筛查所需的工具；（2）检查该州的放射学实践中LDCT的肺癌筛查的可用性。研究将专注于开发和实施数据收集元素，并构建一个安全的数据输入系统，以捕获患者和放射科医生的筛查信息。通过对CT认可的放射学设施进行调查，我们将调查当前在该州进行筛查的设施o特征，并确定随后的扩展阶段的合作伙伴设施。当前，关于LDCT进行肺癌筛查的建议是混杂的，但是随着学术中心和社区实践开始采用这项技术，需要监测筛查经验，以在高风险群体中进行早期检测。这是一项创新的试点研究，它在基于人群的注册表发展和调查方法中使用已建立的方法来探索新兴的临床相关癌症筛查区域，该区域广为人知。拟议的研究之所以重要，是因为它将提供有关非临床试验人群中LDCT用于肺癌筛查的初步数据，并且还将创建一个用于持续数据捕获的系统，这将为肺癌筛查的交付和质量提供信息，因为该技术扩散到社区。