VOLTAGE-GATING MECHANISM OF POTASSIUM CHANNELS

钾通道的电压门控机制

• 批准号: 8363659
• 负责人: FATEMEH KHALILI-ARAGHI
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363659
• 关键词: Animals; Ataxia; Bioinformatics; Calcium Channel; Cardiac; Cardiovascular Diseases; Cations; Cell membrane; Cells; Endocrine; Funding; Grant; Human; Insulin; Integral Membrane Protein; Ions; Life; Long QT Syndrome; Modeling; Muscle Cells; National Center for Research Resources; Nervous system structure; Neurons; Play; Potassium; Potassium Channel; Principal Investigator; Regulation; Research; Research Infrastructure; Resources; Role; Signal Transduction; Sodium Channel; Source; United States National Institutes of Health; Work; cost; electrical potential; nervous system disorder; response; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Voltage-gated potassium (Kv) channels (http://www.ks.uiuc.edu/Research/kvchannel/) are integral membrane proteins present in all three domains of life. In a specialized class of animal cell, known as excitable cells - including neurons, muscle cells, and endocrine cells - Kv channels work with other cation channels (sodium and calcium channels) to regulate the electrical activity and signaling of the cell [1]. Kv channels activate (open and close) in response to changes in the electrical potential across the cell membrane allowing passive and selective conduction of K+ ions through the channel. Potassium conduction is directed by the electrochemical gradient across the cell membrane and can achieve very high rates, while still discriminating against all other cations (including the smaller Na+ ions) [1]. In addition to electrical signaling in nervous systems, Kv channels play an important role in the regulation of cardiac excitability and regulation of insulin release. In humans, malfunction of these channels can result in neurological or cardiovascular diseases such as long QT syndrome or episodic ataxia [2].

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 电压门控钾 (Kv) 通道 (http://www.ks.uiuc.edu/Research/kvchannel/) 是存在于生命所有三个领域的整合膜蛋白。在专门的 一类动物细胞，称为可兴奋细胞 - 包括神经元、肌肉细胞和 内分泌细胞 - Kv 通道与其他阳离子通道（钠和钙）一起工作 通道）来调节细胞的电活动和信号传导[1]。 Kv通道 激活（打开和关闭）以响应跨接电位的变化 细胞膜允许 K+ 离子被动和选择性地传导通过 渠道。钾传导是由电化学梯度引导的 细胞膜，可以达到非常高的速率，同时仍然歧视 所有其他阳离子（包括较小的 Na+ 离子）[1]。除了电气信号之外 在神经系统中，Kv通道在心脏的调节中发挥着重要作用 胰岛素释放的兴奋性和调节。在人类中，这些通道的故障可以 导致神经或心血管疾病，例如长 QT 综合征或阵发性共济失调 [2]。