PADGE

帕吉特

• 批准号: 8363614
• 负责人: LI LI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363614
• 关键词: Bioinformatics; Funding; Genes; Grant; Imagery; Informatics; Molecular Profiling; National Center for Research Resources; Online Systems; Pattern; Principal Investigator; Rank-Sum Tests; Relative (related person); Research; Research Infrastructure; Resources; Sampling; Science; Series; Side; Source; Subgroup; Testing; Tissue-Specific Gene Expression; United States National Institutes of Health; biocomputing; comparative; cost; design; novel; tool; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Percentile Analysis for Differential Gene Expression (PADGE) is a novel tool for identifying genes differentially expressed between two groups of heterogeneous samples. PADGE was designed to compare expression profiles of sample subgroups at a series of percentile cutoffs and to examine the trend of relative expression between sample classes as expression level increases. For comparative analysis, all sample statistical analysis (t test or Wilcoxon rank sum test), the COPA approach (Tomlins et al, Science, 2005) and Kurtosis (Teschendorff, et al, Bioinformatics, 2006) are also implemented and their results are displayed side by side with PADGE, providing a resource of web-based tools for analysis of heterogeneous expression patterns

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 差异基因表达百分位分析 (PADGE) 是一种新工具，用于识别两组异质样本之间差异表达的基因。 PADGE 旨在比较一系列百分位截止值下样品亚组的表达谱，并检查随着表达水平增加样品类别之间的相对表达趋势。对于比较分析，还实施了所有样本统计分析（t 检验或 Wilcoxon 秩和检验）、COPA 方法（Tomlins 等人，Science，2005）和峰度（Teschendorff 等人，Bioinformatics，2006）并显示其结果与 PADGE 并列，提供基于网络的工具资源，用于分析异质表达模式