Neuromodulation in the olfactory system

嗅觉系统的神经调节

• 批准号: 8585842
• 负责人: Ricardo C Araneda
• 金额: $ 35.17万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8585842
• 关键词: Accessory Olfactory Bulbs; Adult; Affect; Aggressive behavior; Aging; Anxiety; Appearance; Applications Grants; Area; Attention; Behavior; Behavioral; Brain; Cell physiology; Cells; Data; Dendrodendritic Synapse; Development; Discrimination; Emotions; Environment; Exhibits; Fiber; Food; Foundations; Lateral; Lead; Learning; Life; Mediating; Medical; Mus; Neurodegenerative Disorders; Neurons; Norepinephrine; Odors; Olfactory Pathways; Partner in relationship; Physiological; Play; Recurrence; Regulation; Research; Role; Sensory; Site; Staging; Study models; Synapses; System; Testing; Therapeutic; adult neurogenesis; granule cell; information processing; inhibitory neuron; insight; neurogenesis; neuronal excitability; neuroregulation; noradrenergic; olfactory bulb; public health relevance; research study

DESCRIPTION (provided by applicant): Remarkably, granule cells (GCs) of the olfactory bulb are continuously born throughout life, providing an excellent neuronal model for the study of both developmental and adult neurogenesis of inhibitory neurons in the brain. As with GCs born during development, cells born in the adult olfactory bulb must establish functional connections with existing neuronal components, including the fibers of the noradrenergic system. This system plays an essential role in sensory information processing in the bulb. The aims outlined in this application seek to understand the physiological role and cellular mechanisms by which the noradrenergic system modulates GC function in the olfactory bulb. In the first two aims, we propose to investigate the cellular mechanisms and physiological role of the excitatory action of noradrenaline on GCs in the main and accessory olfactory bulb. In the last aim, we propose to determine the role of the noradrenergic system on adult neurogenesis of GCs in the context of olfactory mediated behaviors.

描述（由申请人提供）：非常明显的是，嗅球的颗粒细胞（GC）在一生中不断出生，为研究大脑中抑制性神经元的发育和成人神经发生提供了出色的神经元模型。与开发过程中出生的GC一样，成年嗅球中出生的细胞必须与现有的神经元成分（包括甲肾上能系统的纤维）建立功能连接。该系统在灯泡的感觉信息处理中起着至关重要的作用。该应用中概述的目的旨在了解甲肾上腺素能系统调节嗅球中GC功能的生理作用和细胞机制。在前两个目标中，我们建议研究去甲肾上腺素对GC在主要和附属嗅球中GC的兴奋作用的细胞机制和生理作用。在最后一个目标中，我们建议在嗅觉介导的行为的背景下确定去甲肾上腺素能系统对GC的成人神经发生的作用。

项目成果

Pharmacology of mammalian olfactory receptors.

哺乳动物嗅觉受体的药理学。

• DOI: 10.1007/978-1-62703-377-0_15
• 发表时间: 2013
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Smith,RichardS;Peterlin,Zita;Araneda,RicardoC
• 通讯作者: Araneda,RicardoC

Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning.

• DOI: 10.3389/fnsyn.2017.00004
• 发表时间: 2017
• 期刊: Frontiers in synaptic neuroscience
• 影响因子: 3.7
• 作者: Chan W;Singh S;Keshav T;Dewan R;Eberly C;Maurer R;Nunez-Parra A;Araneda RC
• 通讯作者: Araneda RC

Hyperpolarization-Activated Currents and Subthreshold Resonance in Granule Cells of the Olfactory Bulb.

• DOI: 10.1523/eneuro.0197-16.2016
• 发表时间: 2016-09
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Hu R;Ferguson KA;Whiteus CB;Meijer DH;Araneda RC
• 通讯作者: Araneda RC

Regulation of adult neurogenesis by behavior and age in the accessory olfactory bulb.

• DOI: 10.1016/j.mcn.2011.05.003
• 发表时间: 2011-08
• 期刊: MOLECULAR AND CELLULAR NEUROSCIENCE
• 影响因子: 3.5
• 作者: Nunez-Parra, Alexia;Pugh, Victoria;Araneda, Ricardo C.
• 通讯作者: Araneda, Ricardo C.