COMMUNITY-BASED COLORECTAL CANCER PREVENTION IN SOUTH CAROLINA

南卡罗来纳州基于社区的结直肠癌预防

• 批准号: 8360351
• 负责人: Heather M Brandt
• 金额: $ 11.32万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360351
• 关键词: Address; African American; American; Attitude; Behavior; Belief; Cancer Intervention; Characteristics; Colon Carcinoma; Colorectal Cancer; Communities; Cultural Characteristics; Data; Data Analyses; Development; European; Evidence based program; Foundations; Funding; Future; Grant; Incidence; Intervention; Intervention Trial; Interview; Knowledge; Malignant Neoplasms; Modeling; National Center for Research Resources; Phase; Principal Investigator; Public Health; Questionnaires; Research; Research Design; Research Infrastructure; Resources; Review Literature; Rural; Sampling; Screening procedure; Self Efficacy; Source; South Carolina; Surveys; Telephone; Testing; United States National Institutes of Health; Woman; Work; aged; anticancer research; base; colorectal cancer prevention; colorectal cancer screening; comparison group; cost; evidence base; experience; group intervention; health belief; informant; men; mortality; population based; preference; systematic review

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Colorectal cancer (CRC) is one of the most common, deadly, and preventable forms of cancer with marked divergencein screening, incidence, and mortality rates among African Americans and rural residents as compared to European Americans. The proposed study is a two-phased study designed to gather formative research on which a geographicallytargeted, culturally-appropriate CRC intervention can be developed and/or adapted and pilot tested to address CRC in South Carolina. In Phase 1, the proposed study will consist of a population-based, cross-sectional, telephone survey of men and women (aged 45-75) in SC. The cross-sectional telephone study will permit extensive analyses of CRC knowledge, attitudes, beliefs, experiences, and behavior among a population-based sample of men and women in a state with high rates of CRC. The cross-sectional data will be used to determine key knowledge, attitudes, beliefs, behaviors, experiences, and sociodemographic characteristics related to CRC knowledge; identify preferences for CRC educational information; identify barriers to CRC screening; and allow for the development/adaptation of an evidence-based CRC intervention in Phase 2. The questionnaire will be developed by the investigative team by conducting a systematic literature review, expert review, and pretesting. Questionnaire development will be guided by a conceptual framework drawing from the health belief model, self-efficacy construct, and PEN-3 model. Phase 1 data analysis will allow for the identification of geographic and cultural characteristics on which to base a public health intervention. In Phase2, building upon Phase 1 findings, a geographically-targeted, culturally-appropriate evidence-based CRC intervention will be developed and/or adapted and pilot tested for feasibility. A systematic review of existing evidence-based programs and approaches will be conducted as guided by NCI's Using What Works. The content, format, and target audience of the intervention will be based on Phase 1 findings and additional formative research, including the active participation of a community advisory board, key informant interviews, and expert review. The intervention will be pilot tested with one intervention group and one comparison group. The findings of the proposed study will provide a foundation for future NIH proposals and an R01 intervention trial.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 结直肠癌 (CRC) 是最常见、致命且可预防的癌症之一，与欧洲裔美国人相比，非裔美国人和农村居民的筛查、发病率和死亡率存在显着差异。拟议的研究是一项两阶段的研究，旨在收集形成性研究，在此基础上可以开发和/或调整和试点测试有针对性的、文化上合适的CRC干预措施，以解决南卡罗来纳州的CRC问题。在第一阶段，拟议的研究将包括一项基于人口的横断面电话调查 SC 中的男性和女性（45-75 岁）。横断面电话研究将允许对结直肠癌高发州的男性和女性人口样本中的结直肠癌知识、态度、信仰、经验和行为进行广泛分析。横截面数据将用于确定与CRC知识相关的关键知识、态度、信仰、行为、经验和社会人口特征；确定对 CRC 教育信息的偏好；找出结直肠癌筛查的障碍；并允许开发/改编基于证据的 CRC 第二阶段的干预。调查小组将通过系统的文献回顾、专家评审和预测试来制定调查问卷。问卷的制定将以健康信念模型、自我效能感构建和 PEN-3 模型中的概念框架为指导。第一阶段的数据分析将识别地理和文化特征，作为公共卫生干预的基础。在第二阶段，以第一阶段的研究结果为基础，将制定和/或调整并试点测试可行性，以制定和/或调整并试点测试一种具有地理针对性、文化适宜性的循证CRC干预措施。将按照 NCI 的“使用有效方法”的指导对现有循证计划和方法进行系统审查。干预的内容、形式和目标受众将基于第一阶段的研究结果和其他形成性研究，包括社区咨询委员会的积极参与、关键知情人访谈和专家评审。该干预措施将在一组干预组和一组对照组中进行试点测试。拟议研究的结果将为 未来的 NIH 提案和 R01 干预试验。