TAAR1 POLYMORPHISMS IN RHESUS MONKEYS

恒河猴中的 TAAR1 多态性

• 批准号: 8357967
• 负责人: GREGORY MICHAEL MILLER
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357967
• 关键词: Amines; Behavior; Brain; Disease; Drug Addiction; Funding; Gene Family; Genes; Genetic Polymorphism; Grant; Human; Laboratories; Macaca mulatta; Mammals; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rodent; Source; System; United States National Institutes of Health; Variant; base; cost; genetic variant; monoamine; nervous system disorder; neuropsychiatry; novel; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The emerging importance of the TAAR1 receptor in modulating brain monoamine systems provides a strong rationale for determining whether polymorphic variation at the locus is functional and examining the significant similarities between human and rhesus monkeys, as well as other species. We have applied our laboratory's significant expertise in assessing TAAR1 function, polymorphism discovery in rhesus monkey genes associated with drug addiction and neuropsychiatric disorders, and genetic variant functional assessments to investigate of the TAAR1 locus. We identified novel genetic polymorphisms in both the rhesus monkey and human TAAR1, and have found that across species, only the caniform carnivores have a deleted gene. The gene family has seen expansions among certain mammals, notably rodents, and reductions in others, including primates. By placing the trace amine associated receptors in an evolutionary context we can better understand their function and their potential associations with behavior and neurological disease.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 TAAR1 受体在调节大脑单胺系统中的重要性日益显现，为确定该位点的多态性变异是否具有功能性以及检查人类和恒河猴以及其他物种之间的显着相似性提供了强有力的理由。我们应用实验室的重要专业知识评估 TAAR1 功能、与药物成瘾和神经精神疾病相关的恒河猴基因多态性发现以及遗传变异功能评估来研究 TAAR1 位点。我们在恒河猴和人类 TAAR1 中发现了新的基因多态性，并发现在各个物种中，只有犬科食肉动物具有缺失的基因。该基因家族在某些哺乳动物（尤其是啮齿类动物）中有所扩展，而在其他动物（包括灵长类动物）中则有所减少。通过将微量胺相关受体置于进化背景中，我们可以更好地了解它们的功能以及它们与行为和神经系统疾病的潜在关联。