INVESTIGATIONS OF A NEW TYPE ENDOCRINE DISRUPTOR, TCC

新型内分泌干扰物 TCC 的研究

• 批准号: 8357287
• 负责人: Bill Lee Lasley
• 金额: $ 2.52万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357287
• 关键词: Address; Adverse effects; Animal Model; Benign Prostatic Hypertrophy; California; Data; Endocrine Disruptors; Exposure to; Funding; Grant; Human; Investigation; Malignant Neoplasms; National Center for Research Resources; Organ; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rodent; Self Care; Source; United States National Institutes of Health; cost; human disease; nonhuman primate; reproductive; reproductive development; reproductive function; triclocarban

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of the project is to investigate the effects of triclocarban (TCC), a new type endocrine disruptor on reproductive function, reproductive development and the potential effects on inducing cancer in reproductive organs. The results of this project will address concerns relating to the potential effects of adverse effects in humans as a result of exposure to TCC-containing personal care products. The studies using the non-human primate animal model are necessary to provide data that is more relevant to human diseases such as benign prostatic hyperplasia (BPH), compared to traditional data collected with rodent animal models.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目的目的是研究新型内分泌干扰物三氯卡班（TCC）对生殖功能、生殖发育的影响以及诱发生殖器官癌症的潜在影响。 该项目的结果将解决有关因接触含有 TCC 的个人护理产品而对人类产生不良影响的潜在影响的担忧。 与啮齿类动物模型收集的传统数据相比，使用非人类灵长类动物模型的研究有必要提供与良性前列腺增生（BPH）等人类疾病更相关的数据。