Medication development of non-addicting opioid analgesics

非成瘾阿片类镇痛药的药物开发

• 批准号: 8336473
• 负责人: Richard Rothman
• 金额: $ 36.85万
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336473
• 关键词: Adopted; Adverse effects; Agonist; Analgesics; Biological Factors; Blood - brain barrier anatomy; Cell Culture Techniques; Chinese Hamster Ovary Cell; Collaborations; Constipation; Dependence; Development; Evaluation; Goals; Hydrocodone/Acetaminophen; Journals; Manuscripts; Morphine; Mus; Narcotic Analgesics; Opioid; Opioid Analgesics; Oxycodone; Pain; Paper; Pathway interactions; Peptides; Pharmaceutical Chemistry; Pharmaceutical Preparations; Preparation; Publications; Publishing; Reporting; Research; Research Institute; Seminal; Surveys; System; Therapeutic Agents; Ventilatory Depression; Vicodin; Work; addiction; base; delta opioid receptor; design; naltrindole; prescription opioid; prevent; salvinorin A; small molecule; trend

Significant progress was made in the last reporting period, resulting in five publications. One of these papers was a review article published in Pharmacological Reviews, a very high impact journal. The publication of this paper reflects the overall impact of our collaborative work with Dr. Prisinzano on the synthesis and evaluation of compounds related to Salvinorin A. Our collaborative efforts with Dr. Rices group yielded three publications in high impact Medicinal Chemistry journals. Our work with Dr. Prisinzano led to ne publication in the Journal of Natural Products, a leading journal for this type of work. Several manuscripts are in preparation and should be published by the next reporting period.

上一个报告期取得了重大进展，出版了五份出版物。其中一篇论文是发表在影响力非常高的期刊《药理学评论》上的评论文章。本文的发表反映了我们与 Prisinzano 博士的合作对 Salvinorin A 相关化合物的合成和评估的总体影响。我们与 Rices 博士小组的合作在高影响力的药物化学期刊上发表了三篇论文。我们与 Prisinzano 博士的合作在《自然产品杂志》（Journal of Natural Products）上发表了一篇文章，这是此类工作的领先期刊。几份手稿正在准备中，应在下一个报告期之前出版。