Brain Damage and Exercise Neurorestoration After Repeated Binge Alcohol Exposure

反复酗酒后的脑损伤和运动神经恢复

基本信息

批准号：
8731787
负责人：
J. Leigh Leasure
金额：
$ 17.34万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-10 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8731787
关键词：
Abstinence Address Adult Affect Alcohol consumption Alcohol dependence Alcohol-Induced Disorders Alcohols Animal Model Animals Area Astrocytes Brain Brain Injuries Cell Count Cell Death Cells Cognition Cognitive Cognitive deficits Consumption Data Dementia Development Emotional Ensure Epidemiology Exercise Exposure to Female Functional disorder Generations Health Heavy Drinking Hippocampus (Brain)Impaired cognition Impairment Injury Life Mediating Mission Modeling Nerve Degeneration Neurodegenerative Disorders Neuroglia Neurons Oligodendroglia Pattern Prefrontal Cortex Process Public Health Rattus Recovery Recovery of Function Risk Severities Short-Term Memory Stem cells Structure Testing Time United States Withdrawal aging brain alcohol exposure alcohol use disorder binge drinker binge drinking brain behavior brain repair dentate gyrus effective therapy frontal lobe functional disability gliogenesis granule cell improved neurogenesis neurorestoration partial recovery progenitor regenerative relating to nervous system repaired research study restoration sedentary treatment program way finding young adult

项目摘要

DESCRIPTION (provided by applicant): The objective of this proposal is to evaluate cumulative brain damage and the potential for exercise neurorestoration in a rat model of an alcohol use disorder (AUD), which conforms to NIAAA's mission to improve the treatment of AUDs. Binge alcohol consumption impairs cognition and damages the brain by promoting cell death and inhibiting neurogenesis. Exercise, on the other hand, enhances brain health and function. Because binge drinking is a pattern of consumption, and thus by definition occurs repeatedly, this proposal will determine whether exercise can restore the brain after repeated binge episodes. Evidence suggests that repair attempts occur in the brain after a single binge. It is possible that if successive binges occur during ongoing repair attempts, they will not only independently cause damage, but also suppress efforts to repair damage caused by the previous binge. Our proposed experiments will test this hypothesis by timing subsequent binges to overlap with brain repair attempts, and quantify cumulative damage and resulting cognitive impairment. We will assess cognitive impairment both early and chronically after the last binge. We hypothesize that cognitive dysfunction will become more severe and more lasting with increasing binge episodes. Finally, we will determine whether post-binge exercise can ameliorate cumulative brain damage and cognitive dysfunction by allowing abstinent rats to exercise post-binge. We have previously shown that exercise is neuroprotective against damage incurred by a subsequent binge episode. We hypothesize that post-binge exercise will enhance natural brain repair processes during abstinence, resulting in reduced cognitive dysfunction compared to sedentary binge-exposed animals. This application is relevant to public health because it will determine whether exercise could be a useful component of treatment programs aimed at reducing the negative neural and functional consequences of binge alcohol consumption.

描述（由申请人提供）：该提案的目的是评估累积的脑损伤，并在酒精使用障碍大鼠模型（AUD）中进行运动神经修养的潜力，该模型符合NIAAA改善AUD处理的任务。暴饮暴食的消耗会损害认知并通过促进细胞死亡和抑制神经发生来损害大脑。另一方面，运动可以增强大脑健康和功能。由于暴饮暴食是一种消费模式，因此从定义上反复发生，该建议将决定运动后是否可以恢复大脑。有证据表明，一次暴饮暴食后，大脑中发生了修复尝试。如果在进行的维修尝试中连续发生缠绕，它们不仅会独立造成损害，而且还会抑制修复先前狂欢造成的损害的努力。我们提出的实验将通过定时曲线与脑修复尝试重叠并量化累积损害并导致认知障碍来检验这一假设。最后一次狂欢之后，我们将早期和长期评估认知障碍。我们假设认知功能障碍将变得更加严重，并且随着暴饮暴食的增加而变得更加持久。最后，我们将通过允许戒除的大鼠运动后锻炼后，确定暴力运动后运动是否可以改善累积的脑损伤和认知功能障碍。我们以前已经表明，运动对随后的暴饮暴食造成的损害具有神经保护作用。我们假设，与久坐的暴饮暴动动物相比，禁酒后运动将增强自然脑修复过程，导致认知功能障碍降低。该应用与公共卫生有关，因为它将确定运动是否可能是旨在减少暴饮暴食的负面神经和功能后果的治疗计划的有用组成部分。