Cognitive training and practice effects in MCI

MCI 中的认知训练和实践效果

• 批准号: 8696570
• 负责人: KEVIN M DUFF
• 金额: $ 45.9万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8696570
• 关键词: Aftercare; Age; Alzheimer' s Disease; Animals; Auditory; Awareness; Brain; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cognitive deficits; Control Groups; Controlled Clinical Trials; Data; Disease; Double-Blind Method; Education; Elderly; Epidemiology; Exercise; Exposure to; Funding; Future; Health Personnel; Healthcare; Hour; Impaired cognition; Individual; Intervention; Memory; Meta-Analysis; Methodology; Mission; Modeling; National Institute on Aging; Outcome; Outcome Measure; Participant; Patients; Placebo Control; Placebos; Policies; Randomized; Randomized Clinical Trials; Research; Role; Sample Size; Secondary Prevention; Solutions; Symptoms; Testing; Time; Training; Training Programs; Visit; active control; base; clinical care; clinical practice; cognitive function; cognitive training; computerized; daily functioning; demographics; design; disability; donepezil; functional outcomes; impression; improved; intervention effect; mild cognitive impairment; normal aging; prevent; processing speed; public health relevance; response; treatment effect; treatment response

DESCRIPTION (provided by applicant): The overall aim of this submission is to examine if cognitive functioning in MCI can be improved with training exercises. These findings could further our understanding about the mechanisms of MCI, inform our attempts to intervene in this disease, and influence the design and methodology of future clinical trials. We propose a randomized, placebo-controlled, clinical trial using [230] older adults with MCI. Following pre-testing with a cognitive battery, participants will be randomly assigned to either the experimental group or an active control group. Those in the experimental group will complete 40 1-hour sessions of online, computerized exercises designed to improve processing speed and auditory memory (Brain Plasticity, Inc.). Those in the control group will complete 40 1-hour sessions of online, computerized activities that are not specifically designed to improve cognition (e.g., crossword puzzles). Post-testing will follow completion of training in both groups. We will also examine effects of the training program after 12 months. By achieving these aims, we expect to advance our understanding of the mechanisms and treatment of MCI, which will have effects for clinical care and research. For example, if these individuals do benefit from cognitive training, then this may reduce the disability associated with this disease. This project is consistent with the mission of the National Institute on Aging. Relevance. Minimizing the deleterious effects of MCI is critical for providing clinical care and advancing research with this disease. For example, if cognitive deficits can be minimized, then individuals may retain functional independence for longer periods of time. Similarly, awareness of factors that moderate the effects of intervention will allow us to target individuals for future clinical trials in MCI.

描述（由申请人提供）：此提交的总体目的是检查MCI中的认知功能是否可以通过培训练习来改善。这些发现可以进一步了解我们对MCI机制的理解，告知我们对这种疾病进行干预的尝试，并影响未来临床试验的设计和方法。我们提出了使用[230]老年人的随机，安慰剂对照的临床试验。在使用认知电池进行预测试后，参与者将随机分配给实验 组或主动对照组。实验组的人将完成40个1小时的在线计算机练习，旨在提高处理速度和听觉记忆（Brain Profureity，Inc。）。对照组中的那些将完成40个1小时的在线计算机活动，这些活动不是专门设计用于改善认知（例如，填字游戏）。两组的培训完成后，测试后将进行。我们还将在12个月后检查培训计划的效果。通过实现这些目标，我们希望提高我们对MCI机制和治疗的理解，这将对临床护理和研究产生影响。例如，如果这些人确实从认知训练中受益，那么这可能会减少与这种疾病相关的残疾。该项目与国家老化研究所的任务一致。关联。最大程度地减少MCI的有害影响对于提供临床护理和使用该疾病的研究至关重要。例如，如果可以最大程度地减少认知缺陷，则个人可以在更长的时间内保留功能独立性。同样，对缓解干预影响的因素的认识将使我们能够针对MCI的未来临床试验的个人。