RAPID BREATH DETECTION OF LUNG CANCER

肺癌的快速呼吸检测

• 批准号: 8341445
• 负责人: PAUL RHODES
• 金额: $ 15.32万
• 依托单位: ISENSE MEDICAL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8341445
• 关键词: Biological Assay; Biological Markers; Breast; Breath Tests; Cancer Control; Cancer Detection; Cancer Patient; Clinic; Clinical; Clinical Research; Collection; Color; Complex Mixtures; Detection; Development; Devices; Foundations; Gases; Gel; Generations; Institutional Review Boards; Light; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Medical; Medical center; Metabolism; Modification; Optical Instrument; Optics; Performance; Phase; Preparation; Protocols documentation; Resolution; Rest; Sampling; Source; Specificity; System; Technology; Testing; Visible Radiation; Xenon; cancer diagnosis; chemotherapy; cost; follower of religion Jewish; improved; instrument; meetings; next generation; operation; sensor; tumor; ultraviolet

The sensitivity of iSense Medical Corp (IMC) sensor system for the detection of a lung cancer signature from breath will be enhanced and demonstrated, a new breath collection device completed and a modification of the Cleveland Clinic Foundation (CCF) protocol for the ELDDA study of 8000 lung cancer patients and controls will be completed. The first generation of this non-invasive, inexpensice and rapid assay for the presence of lunf cancer has already been tested at CCF wwith specificity and selectivity of detection in the 80s. The next generation of this sensor array,comprising optical indicators embedded in a nanoporous sol-gel matrix is now>100x more sensitive to a range of lung cancer breath markers, enhancing sensitivty for a breast sensor technology already proven effective in lung cancer detection. The approved CCF protocol will be refined to assess the specific claim that following an indeterminate lung CT witht he IMC breath test reduces lung cancer diagnosis false positives over 200%. Further, as lung cancer breath signature arises from active tumor metabolism, the protocol will be adapted to test the hypothesis that the IMC breath rest represents a rapid and low-cost assessment for the efficacy of chemotherapy.

iSense Medical Corp (IMC) 传感器系统用于检测呼吸中肺癌特征的灵敏度将得到增强和证明，新的呼吸收集设备已完成，克利夫兰诊所基金会 (CCF) 协议的修改用于 ELDDA 研究8000名肺癌患者和对照将完成。第一代这种非侵入性、廉价且快速的肺癌检测方法已在 CCF 进行了测试，并在 80 年代具有特异性和选择性。该传感器阵列的下一代由嵌入纳米多孔溶胶-凝胶基质中的光学指示器组成，对一系列肺癌呼吸标记物的敏感度提高了 100 倍以上，从而提高了已被证明在肺癌检测中有效的乳腺传感器技术的灵敏度。批准的 CCF 方案将进行改进，以评估以下具体主张：在不确定的肺部 CT 和 IMC 呼气测试后，肺癌诊断假阳性率可降低 200% 以上。此外，由于肺癌呼吸特征是由活跃的肿瘤代谢产生的，因此该方案将适用于测试这样的假设：IMC 呼吸休息代表了对化疗疗效的快速且低成本的评估。