Skeletal Biology Core

骨骼生物学核心

• 批准号: 8708434
• 负责人: Wenhan Chang
• 金额: $ 22.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708434
• 关键词: Animal Model; Area; Automobile Driving; Biological; Biology; Biomechanics; Cell Culture Techniques; Clinical; Communities; Consultations; Critical Thinking; Data; Data Quality; Degenerative polyarthritis; Development; Discipline; Disease; Etiology; Fostering; Funding; Goals; Histology; Image; Investigation; Medicine; Molecular; Molecular Biology; Musculoskeletal; Musculoskeletal Diseases; Organ; Organism; Osteoporosis; Output; Phenotype; Physicians; Protocols documentation; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Scientist; Services; Skeleton; Tissues; Training; Training Activity; Translations; cost effective; interdisciplinary approach; novel diagnostics; novel strategies; skeletal; skeletal disorder; skeletal tissue; skills

A holistic understanding of the mechanisms producing and maintaining a healthy skeleton requires concurrent investigations of its biological and physical features at molecular, cellular, tissue/organ, and organism levels. Likewise, an interdisciplinary approach is required to identify etiologies of skeletal diseases, like osteoporosis and osteoarthritis. The overall goal of the Skeletal Biology Core is to facilitate the understanding of basic skeletal biology, discovery of disease mechanisms, and development of novel diagnostics and therapies for musculoskeletal disease by providing resources and expertise in different areas of skeletal biology in a highly integrated infrastructure. It is specifically set to overcome three current obstacles ~ the lack of an interdisciplinary approach, funding constraints, and insufficient training for skeletal biologists and physician scientists ~ that hinder skeletal research and its translation into clinical use. This goal will be achieved by providing: (1) a cost-effective one-stop skeletal phenotyping center that allows integrated skeletal tissue analyses from the molecular to cellular, tissue/organ, and organism levels, (2) a dynamic venue for interactions among scientists of various disciplines; and (3) a strong platform for fostering versatile skeletal biologists with a broad set of skills and critical thinking. Specifically, we will (a) establish a sample coordinating office (SCO) to orchestrate sample analyses by: (1) providing consultation with regard to strategies for sample analyses; (2) referring samples to the Imaging Core and/or various SBC sub-cores for concurrent analyses; (3) standardizing protocols; (4) assisting in data interpretation; and (5) compiling reports to the users; (b) develop and integrate the Histology, Biomechanics, Molecular Biology, and Cell Culture sub-cores into a 'one-stop' skeletal phenotyping center to provide high-quality, efficient, costeffective service while driving the development of new approaches; (c) educate and cultivate a community of skeletal investigators by organizing enrichment and training activities. The successful implementation of this Core will not only reduce research expenses and increase the output and quality of data, but also to produce robust in-depth analyses of samples and animal models through integration of different aspects of skeletal biology.

对产生和维持健康骨骼的机制的整体理解需要 同时研究其在分子，细胞，组织/器官以及 生物水平。同样，需要一种跨学科的方法来识别骨骼的病因 疾病，例如骨质疏松和骨关节炎。骨骼生物学核心的总体目标是促进 对基本骨骼生物学的理解，发现疾病机制以及新颖的发展 通过提供不同的资源和专业知识，用于肌肉骨骼疾病的诊断和疗法 高度综合基础设施中的骨骼生物学领域。它专门设置为克服三个电流 障碍〜缺乏跨学科的方法，资金限制和骨骼训练不足 生物学家和医师科学家〜妨碍骨骼研究及其转化为临床使用。这 将通过提供：（1）一个经济高效的一站骨骼表型中心来实现目标 从分子到细胞，组织/器官和生物水平的整合骨骼组织分析，（2）a 各个学科科学家之间互动的动态场所； （3）一个强大的培养平台 具有广泛技能和批判性思维的多功能骨骼生物学家。具体来说，我们将（a）建立一个 样本协调办公室（SCO），通过以下方式协调样本分析 采取样本分析的策略； （2）将样品转介到成像核心和/或各种SBC子核 进行并发分析； （3）标准化协议； （4）协助数据解释； （5）编译 向用户报告； （b）发展和整合组织学，生物力学，分子生物学和细胞 培养子核成“一站式”骨骼表型中心，以提供高质量，高效，成本效益 推动新方法的开发时服务； （c）教育和培养一个社区 骨骼研究人员通过组织丰富和培训活动。成功实施 核心不仅会降低研究费用并增加数据的产出和质量，还可以生产 通过整合骨骼的不同方面的样品和动物模型的深入分析 生物学。