Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study

瑜伽对非裔美国人 CVD 危险因素的影响：杰克逊心脏研究

基本信息

批准号：
8731179
负责人：
GAILEN D. MARSHALL
金额：
$ 55.37万
依托单位：
UNIVERSITY OF MISSISSIPPI MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2016-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8731179
关键词：
Adult African American Alternative Medicine Awareness Blood Blood Pressure Cardiovascular Diseases Cause of Death Cessation of life Cholesterol Clinical Research Crossover Design Diagnosis Diastolic blood pressure Fasting Fibrinogen Glycosylated Hemoglobin Glycosylated hemoglobin A Goals Head Health Health Services Accessibility Health behavior Heart Heart Diseases Hemoglobin concentration result High Density Lipoproteins Homocysteine Homocystine Hybrids Hypertension India Individual Inflammation Institutes Interleukin-6 Intervention Jackson Heart Study Joints LDL Cholesterol Lipoproteins Life Style Lipids Measures Modeling Nature Not Hispanic or Latino Participant Phase Positioning Attribute Poverty Prevention program Randomized Recruitment Activity Reporting Research Design Research Personnel Risk Factors Serum Stress Stroke Target Populations Testing Time Traditional Medicine Triglycerides Yoga cardiovascular disorder risk cohort cost cost effective design health disparity health related quality of life heart disease risk improved meetings multidisciplinary prevent primary outcome public health relevance secondary outcome

项目摘要

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death in the U.S. and continues to be one of the nation's largest racial health disparity conditions: compared to non-Hispanic whites, African Americans are 30 percent more likely to die from heart disease and 60 percent more likely to die from a stroke. African Americans are also more likely than whites to have risk factors for CVD, such as hypertension and elevated levels of cholesterol, triglycerides, and HbA1c. Clinical studies of the effects of yoga on mitigating CVD risk factors, although small in nature, have demonstrated promising results. The proposed study, which utilizes a randomized, hybrid phase-in/cross- over design, includes 500 adult hypertensive or pre-hypertensive African American participants from the Jackson Heart Study to test the effect of yoga classes three times per week for 12 weeks on CVD risk factors. The three specific aims of the study are to measure the effect yoga can have on (1) risks for CVD, including hypertension, inflammation, and elevated levels of lipids and hemoglobin A1c; (2) perceived levels of stress; and (3) health behaviors and health-related quality of life. Primary outcomes will be changes in participants' systolic and diastolic blood pressure and their levels of CRP, fibrinogen, homocysteine, and interleukin-6. Secondary outcomes will be changes in participants' levels of HbA1c, total cholesterol, LDL, HDL, and fasting triglycerides; their perceived levels of stress; and their reported health behaviors and health-related quality of life. Because of the number of participants and the rigor of the research design, this study will be the first of its kind. The study team is in the fortunate position to be able to recruit and retain a large number of participants because of its longstanding-and remarkably close-relationship through their joint association with the Jackson Heart Study. Results will be disseminated on a large scale to a variety of professional and lay audiences. If the results of the intervention yield statistically significant improvement in individuals' CVD risk factors, the nation will benefit from an easily replicable model that can be used to help reduce CVD risk.

描述（由申请人提供）：心血管疾病是美国的主要死亡原因，并且仍然是美国最大的种族健康差异条件之一：与非西班牙裔白人相比，非洲裔美国人死于心脏病的可能性增加了30％，而死于中风的可能性增加了60％。非洲裔美国人也比白人更有可能患有CVD的危险因素，例如高血压和胆固醇，甘油三酸酯和HBA1C的水平升高。瑜伽对缓解CVD危险因素的影响的临床研究表现出了令人鼓舞的结果。拟议的研究利用了一项随机的混合阶段/交叉设计，其中包括杰克逊心脏研究中的500名成人高血压或预性的非裔美国人参与者，以测试每周三次对CVD风险因素的瑜伽课程三次的影响。该研究的三个具体目的是测量瑜伽对CVD的风险的影响，包括高血压，炎症以及脂质和血红蛋白A1C的水平升高；（2）感知压力水平；（3）健康行为和与健康相关的生活质量。主要结果将是参与者的收缩压和舒张压的变化及其CRP，纤维蛋白原，同型半胱氨酸和白介素6的水平。次要结果将是参与者HBA1C，总胆固醇，LDL，HDL和禁食甘油三酸酯水平的变化；他们感知的压力水平；以及他们报道的健康行为和与健康相关的生活质量。由于参与者的数量和研究设计的严谨性，这项研究将是同类研究中的第一项。该研究团队处于幸运的位置，能够招募和留住大量参与者，因为通过与杰克逊心脏研究的联合关系长期存在，并且非常紧密的关系。结果将大规模传播到各种专业和外行观众。如果干预措施的结果在个体的CVD风险因素上产生统计学上的显着改善，则该国将受益于易于复制的模型，该模型可用于降低CVD风险。