Vegetable garden feasibility trial to promote function in older cancer survivors

菜园可行性试验促进老年癌症幸存者的功能

基本信息

批准号：
8619527
负责人：
Wendy Demark-Wahnefried
金额：
$ 19.7万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8619527
关键词：
Activities of Daily Living Adherence Adult Adverse effects Adverse event Affect Age Aging Agriculture Alabama Beginning of Life Behavior Benchmarking Biological Markers Biometry Body Weight Cancer Control Cancer Survivor Cancer Survivorship Cardiovascular Diseases Caring Chinese People Communities Comorbidity Control Groups County Data Diabetes Mellitus Diagnosis Diagnostic Neoplasm Staging Diet Eating Economic Burden Elderly Enrollment Family member Feasibility Studies Fibrin fragment D Future Gender Harvest Health Health behavior Home environment Home visitation House Call Individual Intake Interleukin-6 Intervention Malignant Neoplasms Measures Mental Health Mentors Methods Nursing Homes Osteoporosis Participant Patient Self-Report Performance Physical Function Physical activity Pilot Projects Plants Protocols documentation Proverb Public Health Quality of life Randomized Recruitment Activity Reliance Research Research Infrastructure Research Personnel Risk Rural Sampling Seasons Second Primary Cancers Second Primary Neoplasms Serious Adverse Event Structure Survivors Telomerase Therapeutic Time Translational Research United States Vegetables Venous blood sampling Vulnerable Populations Weight arm base computerized data processing effective intervention fitness follow-up fruits and vegetables functional decline functional disability good diet group intervention health related quality of life holistic approach improved meetings novel novel strategies outcome forecast performance tests programs public health relevance response success treatment as usual trend

项目摘要

Vegetable Garden Feasibility Trial to Promote Function in Older Cancer Survivors There are currently over 13.7 million cancer survivors in the U.S., and the number is steadily increasing. While the rising number of cancer survivors is cause for celebration, cancer survivors are at much greater risk for second malignancies, cardiovascular disease, osteoporosis, and functional impairment. Functional decline, especially that which results in a loss of independence, contributes substantially to the economic burden and also reduces quality of life among cancer survivors and their family members. This is of particular concern among older cancer survivors who comprise the majority (>60%) of all cancer survivors, and whose numbers are expected to exceed 14 million by the year 2030. Thus, there is large public health potential for targeted interventions that stabilize or positively reorient the steep trajectory of functional decline among older cancer survivors. This exploratory study is in response to the Translational Research at the Aging/Cancer Interface (TRACI) (PA-12-135) announcement. and proposes a novel and holistic approach, i.e., gardening, as a way to cultivate long-term adherence to an improved diet and increased physical activity, with the anticipation that it may slow the decline of health and function in this vulnerable population, and promote more successful aging. The proposed feasibility study relies on the extant infra-structure of the Alabama Cooperative Extension Master Gardener Program. A total of 46 older (e65 years) cancer survivors recently diagnosed with a loco-regionally staged cancer with a good prognosis (i.e., e 80% 5-year survival) and with 2 or more physical function limitations will be recruited from select rural and urban counties in Alabama and randomized to 1-of-2 study arms: 1) an intervention group that receives a 1-year mentored vegetable gardening intervention that pairs cancer survivors with certified Master Gardeners, or 2) a usual care control group. Aims of this study are to: 1) explore the feasibility and acceptability of a mentored vegetable gardening intervention by assessing accrual, retention, adherence, fidelity, and possible adverse events, 2) obtain means and precision estimates, and explore between-arm differences on pre-post changes in physical function and secondary endpoints (e.g., quality of life, fruit & vegetable intake, physical activity, biomarkers of successful aging), and 3) to explore participant factors associated with program efficacy (e.g., gender, comorbidity). The proposed vegetable gardening intervention is a novel and feasible strategy to reduce functional impairment and improve quality of life in elderly cancer survivors. The Master Gardener Program exists in all 50 United States, with a large proportion of these states (84%) having the capacity for 2-to-3 growing seasons a year. Thus, there is both an infrastructure and capacity for sustainability and wide-scale dissemination which ultimately could have great public health significance.

菜园的可行性试验以促进老年癌症幸存者的功能目前，美国有超过1,370万癌症幸存者，而且数量正在稳步增加。尽管癌症幸存者的数量增加是庆祝的原因，癌症幸存者的风险要大得多第二个恶性肿瘤，心血管疾病，骨质疏松症和功能障碍。功能下降，尤其是导致独立丧失的损失，对经济负担产生了重大贡献还降低了癌症幸存者及其家人的生活质量。这特别关心在占所有癌症幸存者中大多数（> 60％）的老年癌症幸存者中，其人数预计到2030年将超过1400万。因此，有针对性的公共卫生潜力很大稳定或积极地重新定位了旧癌症功能下降的急剧轨迹的干预措施幸存者。这项探索性研究是对衰老/癌症界面的转化研究的回应（Traci）（PA-12-135）公告。并提出了一种新颖而整体的方法，即园艺，以此作为一种方式培养长期遵守饮食的依从性并增加体育锻炼，并期待它在这个脆弱的人群中，健康和功能的下降可能会减缓，并促进更成功的衰老。拟议的可行性研究依赖于阿拉巴马州合作扩展大师的现有基础结构园丁计划。最近总共有46个年龄较大（E65岁）的癌症幸存者最近被诊断出患有机能区域具有良好预后的癌症（即E 80％5年生存）和2个或更多的身体功能将从阿拉巴马州的某些农村和城市县招募限制，并随机分为2个研究武器：1）一个接受1年指导的蔬菜园艺干预措施的干预组拥有经过认证的园丁的癌症幸存者，或2）通常的护理控制组。这项研究的目的是：1）通过评估应计，探索受过指导的蔬菜园艺干预措施的可行性和可接受性保留，依从性，保真度和可能的不利事件，2）获得均值和精度估计，并探索在物理功能和次要终点的前post变化上的臂间差异（例如，生活质量，水果和蔬菜摄入量，体育锻炼，成功衰老的生物标志物）和3）探索与计划功效相关的参与者因素（例如性别，合并症）。提议的蔬菜园艺干预是一种新颖且可行的策略，可减少功能障碍并提高质量老年癌症幸存者的生活。园丁大师计划存在于美国所有50个这些州的比例（84％）每年具有2到3个生长季节的能力。因此，有一个基础设施和可持续性和广泛传播的能力，最终可能具有巨大的公共卫生意义。