FASEB SRC on Yeast Chromosome Structure, Replication and Segregation

FASEB SRC 关于酵母染色体结构、复制和分离

基本信息

批准号：
8781775
负责人：
Kathleen L Gould
金额：
$ 0.8万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-13 至 2015-06-12
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8781775
关键词：
Address Aging Agreement Air American Animal Model Area Behavior Biochemistry Biological Factors Biology Biophysics Caring Cell physiology Cellular biology Chromosome Structures Chromosomes Collaborations Colorado Communities Complex Cytology DNA Data Defect Discipline Disease Electromagnetic Energy Emerging Technologies Environment Environmental Risk Factor Evolution Feedback Fission Yeast Fostering Gene Expression Profile Genetic Genome Genomics Goals Health Hereditary Disease Human Human Genetics Image Information Technology Laboratories Laboratory Organism Lead Malignant Neoplasms Meiosis Metabolism Mission Molecular Molecular Biology National Institute of Environmental Health Sciences National Institute on Aging Nicotine Organism Participant Pathology Play Postdoctoral Fellow Premature aging syndrome Principal Investigator Process Proteins Recording of previous events Research Research Personnel Rewards Role Saccharomyces cerevisiae Saccharomycetales Scientist Series Signal Transduction Societies Source Stress Systems Biology Time Toxic effect Water Yeasts abstracting age related base carcinogenicity career cell growth design environmental agent graduate student innovation insight meetings novel strategies pollutant posters programs public health relevance repaired segregation single molecule symposium transmission process unpublished works

项目摘要

DESCRIPTION (provided by applicant) This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Yeast Chromosome Structure, Replication, and Segregation to be held July 13-18, 2014 in Steamboat Springs, Colorado. This will be the thirteenth bi-annual iteration of what has become the most successful and important meeting for this field. This conference aims to join investigators studying many diverse aspects of chromosome biology and cell biology in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe, using a range of experimental approaches including genetics, cytology, biochemistry, single molecule imaging, molecular biology, genomics, and systems biology. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited for studies of chromosome biology in more complex experimental organisms and in humans. Environmental agents - including manmade air- and water-borne pollutants, electromagnetic radiation, and nicotine and other natural products - can have profound effects on the replication, segregation, and repair of chromosomes. Moreover, an organism's environment has a strong impact on gene expression patterns. As such, chromosomes are critical targets through which the environment exerts toxic, mutagenic, and carcinogenic effects. The cellular processes that maintain genome integrity in the face of insults from environmental and endogenous sources are thus of fundamental importance for human health and disease. Many critical questions in these areas remain unresolved, and yeasts are outstanding model organisms for addressing these questions because of the evolutionary conservation of many of the molecular mechanisms and proteins involved. Much of the conference will thus be devoted to topics firmly within the mission of the National Institute of Environmental Health Sciences. Changes in chromosome behaviors accompany normal cellular and organismal aging and contribute to age-related pathologies such as chromosome mis-segregation during meiosis, and human genetic diseases associated with aberrant DNA metabolism are often accompanied by hallmarks of premature aging. Yeasts have long played a dominant role in studies of the fundamental mechanisms underlying normal and pathological chromosome dynamics, thus the topics covered in this conference also support the missions of the National Institute on Aging.

描述（由申请人提供）本申请寻求对将于 2014 年 7 月 13 日至 18 日在科罗拉多州斯廷博特斯普林斯举行的美国实验生物学会联合会 (FASEB) 酵母染色体结构、复制和分离会议的部分支持。这将是该领域最成功、最重要的会议的第十三次会议。本次会议旨在与研究人员一起研究芽殖酵母酿酒酵母和裂殖酵母粟酒裂殖酵母的染色体生物学和细胞生物学的许多不同方面，使用一系列实验方法，包括遗传学、细胞学、生物化学、单分子成像、分子生物学、基因组学和系统生物学。演讲将介绍有关该领域及时问题的新的和未发表的工作，并将包括所有参与者的讨论。 FASEB 会议为交流信息和技术提供了独特的机会，这些信息和技术可用于更复杂的实验生物体和人类染色体生物学的研究。环境因素——包括人造空气和水污染物、电磁辐射、尼古丁和其他天然产物——可以对染色体的复制、分离和修复产生深远的影响。此外，生物体的环境对基因表达模式有很大影响。因此，染色体是环境发挥毒性、诱变和致癌作用的关键目标。因此，在面对环境和内源性来源的损伤时保持基因组完整性的细胞过程对于人类健康和疾病至关重要。这些领域的许多关键问题仍未解决，而酵母是解决这些问题的杰出模式生物，因为许多涉及的分子机制和蛋白质的进化保守性。因此，会议的大部分内容将集中讨论国家环境健康科学研究所使命范围内的主题。染色体行为的变化伴随着正常细胞和有机体的衰老，并导致与年龄相关的病理学，例如减数分裂过程中的染色体错误分离，而与异常DNA代谢相关的人类遗传疾病通常伴随着过早衰老的特征。长期以来，酵母在正常和病理染色体动力学的基本机制研究中发挥着主导作用，因此本次会议涵盖的主题也支持国家衰老研究所的使命。