Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network

尤尼斯·肯尼迪·施赖弗 (Eunice Kennedy Shriver) NICHD 合作多中心新生儿研究网络

基本信息

批准号：
8643279
负责人：
CHARLES Michael COTTEN
金额：
$ 29.95万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-05-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8643279
关键词：
Active Sites Apolipoprotein E Autologous Award Biomedical Engineering Blood Cells Bronchopulmonary Dysplasia Candidate Disease Gene Candidiasis Caring Cataloging Catalogs Childhood Clinic Clinical Research Clinical Sciences Clinical Trials Clinical Trials Network Clinical and Translational Science Awards Collaborations Commit Communicable Diseases Cost Sharing DNA Library Databases Development Diagnosis Discipline Early Diagnosis Enrollment Extremely Low Birth Weight Infant Faculty Fostering Funding Generic Drugs Genomics Genotype Goals Grant Health Human Resources Infant Instruction Lead Link Low Birth Weight Infant Manuscripts Marshal Medical Mentors Morbidity - disease rate Multicenter Neonatal Research Network National Institute of Child Health and Human Development Neonatal Neonatal Screening Neonatology Newborn Infant North Carolina Outcome Patients Perinatal Pilot Projects Population Study Pregnancy Preparation Price Principal Investigator Protocols documentation Publications Reporting Research Research Institute Research Personnel Resources Sampling Scientist Site Societies Testing The science of Mycology Therapeutic Training Translational Research Umbilical Cord Blood United States National Institutes of Health Universities Work career development experience follow-up genetic epidemiology genome wide association study improved innovation interdisciplinary approach medical schools multidisciplinary natural hypothermia neonatal hypoxic-ischemic brain injury neonate new technology patient population public health relevance sound symposium

项目摘要

DESCRIPTION (provided by applicant): The Duke University School of Medicine, Division of Neonatology enthusiastically submits this renewal application for a third consecutive cycle of participation in the Eunice Kennedy Shriver NlCHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). The NRN's purpose is to perform interventional and observational clinical studies in newborn infants, particularly those of low birth weight or gestation, with the goal of achieving improved medical and neurodevelopmental outcomes. Our aims at Duke are to: 1) prioritize and conduct approved NRN protocols while maintaining a > 90% follow-up rate; 2) foster development of trainees and collaborations with investigators from multiple disciplines to advance the care of neonates; 3) bring innovative, cutting-edge research opportunities to the NRN. In support of these aims we added the University of North Carolina at Chapel Hill (UNC) as a satellite site in January 2009. The addition of UNC doubles the study population and enhances our clinical trial expertise. We are the only current NRN site participating in all three current NRN pilot studies, and enrolled the 3'^ highest number of infants in the 2009 Generic Data Base. We maintain multidisciplinary follow-up clinics with follow-up rates for clinical trials > 90%. We participate in nine active NRN subcommittees, and lead two major Network projects that combine institutional expertise in Infectious Diseases, Medical Mycology, Biomedical Engineering, and Genetic Epidemiology, namely, Early Diagnosis of Neonatal Candidiasis and the NICHD NRN Anonymized DNA Bank. In 2010 we and investigators from 5 NRN sites are using the DNA bank to complete a genome wide scan and 7 candidate gene analyses for common morbidities of extremely low birthweight infants. We have authored or co-authored 16 NRN publications in the last cycle. We prioritize involvement of junior faculty in the NRN as attested by their concept and study applications and participation in subcommittees. At PAS in 2010 young investigators from Duke and two other NRN sites presented secondary analyses of the Candidiasis study. Duke and UNC are Clinical and Translational Science Award (CTSA) sites. CTSA directly supports our NRN work and adds further opportunity for innovation.

描述（由申请人提供）：杜克大学医学院，新生儿学系热情地提交了这一续签申请，连续第三个参与Eunice Kennedy Shriver NLCHD赞助的合作合作多中心新生儿研究网络（NRN）。 NRN的目的是对新生婴儿，尤其是出生体重或妊娠的介入和观察性临床研究进行介入和观察性临床研究，以实现改善的医疗和神经发育结果。我们对杜克大学的目标是：1）优先级和执行批准的NRN协议，同时保持> 90％的随访率； 2）促进学员的发展和与来自多个学科的调查人员的合作，以推动新生儿的照顾； 3）为NRN带来创新的尖端研究机会。为了支持这些目标，我们在2009年1月将北卡罗来纳大学的教堂山分校（UNC）添加为卫星站点。UNC的增加增加了研究人群并增强了我们的临床试验专业知识。我们是当前参与所有三项NRN试点研究的唯一当前NRN站点，并且在2009年通用数据库中招募了3'^最高婴儿。我们维持多学科的随访诊所，其临床试验的随访率> 90％。我们参加了9个活跃的NRN小组委员会，并领导了两个主要的网络项目，这些项目结合了传染病，医学真菌学，生物医学工程和遗传流行病学方面的机构专业知识，即对新生儿念珠菌病和NICHD NRN Anymined DNA Bank的早期诊断。 2010年，我们和来自5个NRN站点的研究人员正在使用DNA库来完成基因组广泛的扫描和7种候选基因分析，以分析极低的出生体重婴儿的常见病因。在上一个周期中，我们撰写或合着了16个NRN出版物。我们优先考虑初级教师参与NRN，这是由他们的概念和研究应用和参与小组委员会的参与。在2010年的PAS上，来自杜克大学的年轻研究人员和其他两个NRN站点进行了念珠菌病研究的次要分析。公爵和UNC是临床和转化科学奖（CTSA）网站。 CTSA直接支持我们的NRN工作，并增加了创新的机会。