Stress-induced Drinking in OEF/OIF Veterans: The Role of Combat History and PTSD

OEF/OIF 退伍军人压力诱发的饮酒：战斗史和 PTSD 的作用

基本信息

批准号：
8299158
负责人：
ANANDA B AMSTADTER
金额：
$ 31.8万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8299158
关键词：
21 year old Acute Address Adult Affect Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcohols Alleles Auditory Behavior assessment Biological Blood Pressure Blood specimen Clinical Control Groups Corticotropin Counseling Data Dependence Diagnostic Distress Emotional Event Exposure to Funding Genes Genetic Genetic Polymorphism Goals Human Hydrocortisone Incidence Individual Laboratories Laboratory Study Life Measures Mediating Military Personnel National Institute on Alcohol Abuse and Alcoholism Nature Neurosecretory Systems Participant Patient Self-Report Personality Traits Physiological Play Population Post-Traumatic Stress Disorders Preventive Intervention Procedures Psychopathology Randomized Reaction Recording of previous events Recruitment Activity Research Research Personnel Risk Role Serum Societies Stimulus Stress Testing Time Trauma Trier Social Stress Test Veterans acute stress age group alcohol research alcohol response biological adaptation to stress career combat computerized cost design distress tolerance drinking drinking behavior emerging adult experience high risk indexing meetings neglect operation prevent promoter psychologic psychological stressor public health relevance response serotonin transporter stressor

项目摘要

DESCRIPTION (provided by applicant): Military personnel exposed to combat-related traumatic events, particularly those who develop posttraumatic stress disorder (PTSD), have a higher incidence of problematic drinking. However, little is known about the relationship between trauma, PTSD, and drinking in "emerging adults" (ages 21-30 years), in spite of this age group being at highest risk of developing subsequent drinking problems. The proposed clinical laboratory project will use a three group design. The target OIF/OEF population will have no trauma exposure [Control group], combat trauma exposure without PTSD [TE group], and combat trauma exposure with PTSD [PTSD group]. The type of traumatic event exposure history included will be limited to combat- related traumatic events that are interpersonal in nature. This project will use a well-established clinical laboratory paradigm of stress induction employed by our group, the Trier Social Stress Test (TSST), to investigate the role of a history of exposure to combat trauma on reactivity to the TSST and on stress- induced voluntary drinking. Subjects will not meet diagnostic criteria for alcohol dependence. Half of each group will receive the TSST and the other half will be randomized to the no stress condition. Using subjective as well as biological indices of stress, the first specific aim examines the effect of combat trauma history on stress reactivity, using subjective, neuroendocrine, and physiological measures of stress. The second specific aim will examine the effect of combat trauma history on subsequent drinking behavior and subjective response to alcohol using established procedures in a clinical laboratory paradigm. Exploratory analyses will also be conducted to examine the correlation between combat trauma history group and subjective response to stress, and combat trauma history group and drinking. Two additional exploratory analyses will evaluate the effect of the personality trait of distress tolerance (high and low), and the effect of carrying the 'S' or the rare 'LG' allele of the 5-HTTLPR polymorphism on the stress response and on voluntary drinking following stress induction. This study will advance our understanding of the relationship between a history of combat-related traumatic events, stress, and drinking. The ultimate goal of this line of research is to identify "at risk" groups early in their drinking careers, before unhealthy drinking practices and/or dependence develop. This information has the potential to inform prevention and intervention alcohol research. PUBLIC HEALTH RELEVANCE: By providing data related to the interaction of stress and drinking from a relatively neglected group of subjects, young OIF/OEF adults between 21-30 who have been exposed to combat-related traumatic events it may be possible to prevent alcohol dependence from developing and, thereby, reduce the magnitude of costs to the individual and to society.

描述（由申请人提供）：经历过与战斗相关的创伤事件的军事人员，特别是患有创伤后应激障碍（PTSD）的军事人员，饮酒问题的发生率较高。然而，人们对“新兴成年人”（21-30 岁）的创伤、创伤后应激障碍和饮酒之间的关系知之甚少，尽管这个年龄段出现后续饮酒问题的风险最高。拟议的临床实验室项目将采用三组设计。目标 OIF/OEF 人群将没有创伤暴露[对照组]、没有 PTSD 的战斗创伤暴露[TE 组]、以及患有 PTSD 的战斗创伤暴露[PTSD 组]。所包括的创伤事件暴露史的类型将仅限于本质上是人际的与战斗相关的创伤事件。该项目将使用我们小组采用的成熟的压力诱导临床实验室范式，即特里尔社会压力测试（TSST），以研究战斗创伤暴露史对 TSST 反应性和压力诱导的作用。自愿饮酒。受试者不符合酒精依赖的诊断标准。每组的一半将接受 TSST，另一半将被随机分配到无压力条件。第一个具体目标利用主观和生物压力指标，利用主观、神经内分泌和生理压力测量方法，检查战斗创伤史对压力反应性的影响。第二个具体目标将使用临床实验室范例中的既定程序来检查战斗创伤史对随后饮酒行为和对酒精的主观反应的影响。还将进行探索性分析，以检查战伤史组与对压力的主观反应以及战伤史组与饮酒之间的相关性。另外两项探索性分析将评估应激耐受性（高和低）的人格特征的影响，以及携带“S”或 5-HTTLPR 多态性的罕见“LG”等位基因对应激反应和自愿的影响应激诱导后饮酒。这项研究将增进我们对战斗相关创伤事件史、压力和饮酒之间关系的理解。这一系列研究的最终目标是在不健康的饮酒习惯和/或依赖性形成之前，在饮酒生涯的早期识别“高危”群体。这些信息有可能为预防和干预酒精研究提供信息。公共卫生相关性：通过提供相对被忽视的受试者群体（21-30 岁之间、经历过与战斗相关的创伤事件的年轻 OIF/OEF 成年人）有关压力和饮酒相互作用的数据，可能可以预防酒精依赖从而减少个人和社会的成本。