Epstein Barr virus antisense transcription

Epstein Barr病毒反义转录

• 批准号: 8750146
• 负责人: ERIK K FLEMINGTON
• 金额: $ 37.63万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-18 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8750146
• 关键词: Acquired Immunodeficiency Syndrome; Architecture; B-Lymphocytes; Code; Complex; DNA; DNA biosynthesis; Fractionation; Functional RNA; Genes; Genetic Transcription; Human Herpesvirus 4; Immune system; Infection; Life Cycle Stages; Lymphoma; MicroRNAs; Modeling; Molecular; Molecular Target; Northern Blotting; Oncogenic; Patients; Phase; Play; Process; Production; Property; Proteins; RNA; Role; Signal Transduction; Texture; Therapeutic; Time; Transcript; Viral; Viral Proteins; Virion; Virus; Virus Replication; public health relevance; response; tool; trafficking; viron

DESCRIPTION: Reactivation in B-cells is critical for the Epstein Barr virus (EBV) life cycle and it plays a role in amplifying viral titers in AIDS patients. The repertoire of EBV genes thought to be involved in viral replication consists primarily of approximately 80-90 protein-coding genes. These viral proteins play very diverse roles in virus production including roles in DNA replication, RNA transcription, molecular trafficking, virion assembly, viral egress, host shut-off etc. This is not to mention roles as viron components; both components that form the virus architecture as well as those that are involved in inducing the rapid signaling responses immediately following new infection. We hypothesize that in addition to this group of known protein coding genes, EBV encodes a previously unappreciated group of long non-coding transcripts that will ultimately be found to play an equally diverse set of functions in virus replication. Conceptually this would be important because it would change the texture and the details of how most of us visualize the reactivation process. From a practical standpoint, it would give us a new class of molecular targets that may offer the application of alternative therapeutic approaches against EBV.

描述：B细胞中的重新激活对于爱泼斯坦Barr病毒（EBV）生命周期至关重要 在扩增艾滋病患者的病毒滴度中起作用。 EBV基因的曲目被认为是 参与病毒复制主要由大约80-90个蛋白质编码基因组成。这些病毒蛋白在病毒生产中起着非常多样化的作用，包括在DNA复制，RNA转录，分子运输，病毒体组装，病毒式出口，宿主关闭等方面的作用。构成病毒架构的两个成分以及参与新感染后立即引起快速信号反应的组件。我们假设，除了这组已知的蛋白质编码基因外，EBV还编码了先前未批准的长期非编码转录本，最终将发现它们在病毒复制中起着同样多样化的功能。从概念上讲，这将很重要，因为它将改变我们大多数人如何可视化重新激活过程的纹理和细节。从实际的角度来看，它将 为我们提供一类新的分子靶标，这些靶标可能会应用针对EBV的替代治疗方法。