FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION DEFICIT H

注意力缺陷儿童多模式治疗研究的随访 H

基本信息

批准号：
8233203
负责人：
HOWARD Barry ABIKOFF
金额：
$ 23.66万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-23 至 2013-02-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8233203
关键词：
Accidents Achievement Address Alcohol or Other Drugs use Amphetamines Anxiety Attention Attention deficit hyperactivity disorder Behavior Behavior Therapy Behavioral Symptoms Blood Pressure Child Child Rearing Combined Modality Therapy Communities Comorbidity Contracts Control Groups Data Collection Disease Dose Eating Disorders Educational Status Effectiveness Exposure to Goals Grant Growth Health Heart Rate Height Incidence Independent Living Individual Long-Term Effects Mediation Mediator of activation protein Medical Medication Management Mental Depression Mental Health Mental disorders Modality National Institute of Mental Health Occupational Outcome Participant Pharmaceutical Preparations Phase Psychopathology Psychotic Mood Disorders Puberty Randomized Relative (related person)Research Research Design Research Personnel Risk Schools Services Site Speed Substance Addiction Substance abuse problem Support Contracts Symptoms Tic disorder Time U-Series Cooperative Agreements adverse outcome clinical research site design follow-up psychosocial psychotic mania social standard care suicidal behavior treatment as usual treatment site

项目摘要

The purpose of this contract is to study the long-term effects of different treatment modalities for children with attention deficit hyperactivity disorder (ADHD) through a systematic follow-up of the subjects who participated in the Multimodal Treatment Study of Children with ADHD (MTA). The initial design and planning phase of the MTA study occurred during the latter portion of 1992 thru the end of 1993, where the divergent study designs and goals of the various investigators were blended into a cohesive, coherent, and scientifically rigorous final design. The 24-month MTA Study (14 months of treatment, followed by a 10-month follow-up assessment) of 579 children with ADHD was conducted at seven treatment sites over the course of the next four years. Participants were assessed before, during, and at the end of 14 months of treatment, and 10 months later. Treatment was received depending on to which one of four groups participants were randomized (medication alone, behavioral treatment alone, medication plus behavioral treatment, community treatment as usual). This five-year period was supported by NIMH cooperative agreement grants to the clinical sites. At the 24-month point, a Local Normative Control Group of grade- and school-matched non-patients was added as a comparator group. With the support of a subsequent competing supplement to each site, 36-month follow-up assessments were completed. The original MTA aims addressed the following questions: What are the differences in effectiveness for medication management versus intensive behavioral treatments? What are the additive/synergistic effects of combined medication and psychosocial treatment compared to either treatment delivered alone? What is the relative effectiveness of systematic, well-delivered treatments vs. ¿standard¿ treatments typically received in the community? Additional questions the MTA investigators sought to address included the prediction and mediation of treatment-related gains from individual (e.g., co-morbidity), familial (e.g., child-rearing practices), and/or social (e.g., SES) variables. This current contract supports assessment and data collection for follow-up year 12 of the MTA study, at the seven original sites. Each site is supported by an individual contract to that site.

该合同的目的是通过对参加注意力缺陷多动症儿童多模式治疗研究（MTA）的受试者进行系统随访，研究不同治疗方式对注意力缺陷多动症（ADHD）儿童的长期影响MTA 研究的初始设计和规划阶段发生在 1992 年下半年至 1993 年底，在此阶段，不同研究人员的不同研究设计和目标被融合成一个有凝聚力、连贯性和一致性的研究计划。为期 24 个月的 MTA 研究（14 个月的治疗，随后进行 10 个月的随访评估）在接下来的四年中在七个治疗点进行。在治疗前、治疗期间和治疗结束时以及 10 个月后进行评估，具体取决于参与者被随机分配到四组中的哪一组（单独药物治疗、单独行为治疗、药物加行为治疗、社区治疗）。这五年期得到了 NIMH 向临床中心提供的合作协议资助。在 24 个月时，增加了一个由年级和学校匹配的非患者组成的当地规范对照组作为比较组。随后对每个站点进行了竞争性补充，完成了36个月的跟踪评估。 MTA 最初的目标解决了以下问题：药物管理与强化行为治疗的有效性有何差异？与单独提供的任何一种治疗相比，联合药物治疗和心理社会治疗的相加/协同效应是什么？，良好的治疗 vs.标准MTA 调查人员试图解决的其他问题包括预测和调节来自个人（例如共病）、家庭（例如抚养孩子的做法）和/或社会（例如，SES）变量。当前的合同支持 MTA 研究的后续第 12 年在七个原始站点的评估和数据收集。每个站点均由该站点的单独合同提供支持。