Beagle-2

小猎犬2号

基本信息

批准号：
8734865
负责人：
Ian Foster
金额：
$ 199.98万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2015-07-31
项目状态：
已结题

项目摘要

DESCRIPTION: Biomedical research increasingly depends on big data analysis and large-scale simulation. In 2009, the University of Chicago's Biological Sciences Division identified computational biomedicine as its major strategic focus for research, recruitment and strategic investment. The centerpiece of this initiative was the acquisition of Beagle-1, an 18,000-core, 600 TB supercomputer that ranked among the world's most powerful machines dedicated to biological and medical research. Since its debut in early 2011, more than 300 researchers from 89 projects have used Beagle-1, utilizing over 300 million core-hours of computing time. With Beagle-1, scientists pushed forward the frontiers of research on cancer, neuroscience, genetics, cardiovascular disease, microbiology, drug design, and other areas. Work conducted on Beagle-1 also sparked the emergence of a vibrant computational biomedicine community on the University Chicago campus and across the Chicago region, where faculty, post-docs, students and staff benefit from frequent workshops, seminars and educational opportunities. The surge in demand for biomedical supercomputing concomitant with Beagle-1 approaching the end of its life necessitates the acquisition of a new, more powerful resource: Beagle-2, a 23,808-core, 1.3 petabyte Cray XE6 system. This major upgrade will increase computational and big data storage capabilities by two fold while also delivering service for researchers through 2017. An estimated 150 million core hours per year for this system can already be filled by active, NIH-funded projects studying the genetics of cancer and myopathies, the microbiology of the human gut and its relationship to disease, the use of medical images to create personalized treatments for cancer, the cell biology of Alzheimer's disease, the evolutionary origins of language centers in the brain, and much more. Beagle-2 will allow the University of Chicago to further develop a biomedical computing facility that enhances research and patient care, trains the next generation of biomedical computing experts, enables collaboration by researchers across the Chicago region and beyond, and produces transformative new methods, software tools, and data products that will advance biomedical research on a global scale.

描述：生物医学研究越来越取决于大数据分析和大规模模拟。 2009年，芝加哥大学的生物科学系确定计算生物医学是其研究，招聘和战略投资的主要战略重点。该计划的核心是收购Beagle-1，Beagle-1是一个18,000核，600 TB超级计算机，在全球最强大的机器中排名为生物学和医学研究。自2011年初首次亮相以来，来自89个项目的300多名研究人员使用了Beagle-1，利用了超过3亿个计算时间的核心时间。利用Beagle-1，科学家推动了有关癌症，神经科学，遗传学，心血管疾病，微生物学，药物设计和其他领域的研究领域。在Beagle-1上进行的工作还引发了芝加哥大学校园和芝加哥地区的充满活力的计算生物医学社区的出现，教职员工，毕业后，学生和员工从经常的研讨会，研讨会和教育机会中受益。与Beagle-1结束生命的生物医学超级计算的需求激增需要获得一种新的，更强大的资源：Beagle-2，一个23,808核，1.3 PB的Cray XE6系统。这次重大升级将使计算和大数据存储能力提高两倍，同时在2017年为研究人员提供服务。该系统的每年估计每年1.5亿个核心小时已经通过活跃的，NIH资助的项目来填补，研究了癌症的遗传学。肌病，人类肠道的微生物及其与疾病的关系，使用医学图像为癌症创造个性化治疗，阿尔茨海默氏病的细胞生物学，大脑中语言中心的进化起源，等等。 Beagle-2将使芝加哥大学能够进一步开发一种生物医学计算设施，从而增强研究和患者护理，培训下一代生物医学计算专家，使芝加哥地区及其他地区的研究人员合作，并产生变革性的新方法，软件，软件，软件，软件工具和数据产品将在全球范围内推进生物医学研究。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature).

DOI：
10.1038/s41598-017-00122-x
发表时间：
2017-03-03
期刊：
Scientific reports
影响因子：
4.6
作者：
Yang XH;Tang F;Shin J;Cunningham JM
通讯作者：
Cunningham JM

High-throughput cancer hypothesis testing with an integrated PhysiCell-EMEWS workflow

DOI：
10.1186/s12859-018-2510-x
发表时间：
2018-12-21
期刊：
BMC BIOINFORMATICS
影响因子：
3
作者：
Ozik, Jonathan;Collier, Nicholson;Macklin, Paul
通讯作者：
Macklin, Paul

The Crisis of Reproducibility, the Denominator Problem and the Scientific Role of Multi-scale Modeling.

DOI：
10.1007/s11538-018-0497-0
发表时间：
2018-12
期刊：
Bulletin of mathematical biology
影响因子：
3.5
作者：
An G
通讯作者：
An G

Scaled laboratory experiments explain the kink behaviour of the Crab Nebula jet.

DOI：
10.1038/ncomms13081
发表时间：
2016-10-07
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Li, C. K.;Tzeferacos, P.;Lamb, D.;Gregori, G.;Norreys, P. A.;Rosenberg, M. J.;Follett, R. K.;Froula, D. H.;Koenig, M.;Seguin, F. H.;Frenje, J. A.;Rinderknecht, H. G.;Sio, H.;Zylstra, A. B.;Petrasso, R. D.;Amendt, P. A.;Park, H. S.;Remington, B. A.;Ryutov, D. D.;Wilks, S. C.;Betti, R.;Frank, A.;Hu, S. X.;Sangster, T. C.;Hartigan, P.;Drake, R. P.;Kuranz, C. C.;Lebedev, S. V.;Woolsey, N. C.
通讯作者：
Woolsey, N. C.

MICROSIMULATION MODEL CALIBRATION USING INCREMENTAL MIXTURE APPROXIMATE BAYESIAN COMPUTATION.