Efficacy of swedish massage therapy on cancer-related fatigue in cancer survivors

瑞典按摩疗法对癌症幸存者癌症相关疲劳的疗效

• 批准号: 8657011
• 负责人: Mark Hyman Rapaport
• 金额: $ 19.21万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8657011
• 关键词: Address; Alternative Therapies; Anti-Inflammatory Agents; Anti-inflammatory; Area; Attention; Basic Science; Behavior; Biological; Biological Assay; Biology; Cancer Etiology; Cancer Patient; Cancer Survivor; Chronic; Complementary and alternative medicine; Data; Development; Distress; Equipment and supply inventories; Evidence based treatment; Expectancy; Fatigue; Feasibility Studies; Future; Goals; Immune; Immune system; In Vitro; Inflammation; Inflammatory; Interferons; Interleukin-1; Interleukin-10; Interleukin-6; Intervention; Investigation; Light; Malignant Neoplasms; Manuals; Massage; Measurement; Measures; Mediating; Mitogens; Modality; National Center for Complementary and Alternative Medicine; Patient Outcomes Assessments; Plasma; Publishing; Quality of life; Radiation; Randomized; Randomized Controlled Trials; Research; Role; Science; Shapes; Social Behavior; Strategic Planning; Subgroup; Symptoms; System; TNF gene; Therapeutic; Therapeutic Effect; Touch sensation; Treatment outcome; United States; Waiting Lists; anakinra; base; cancer therapy; cancer type; chemotherapy; cytokine; effective intervention; experience; immune activation; immune function; indexing; malignant breast neoplasm; preference; public health relevance; relating to nervous system; response; symptom management

DESCRIPTION (provided by applicant): With approximately 12 million cancer survivors today in the United States alone, increased attention is being given to quality of life after cancer treatment. Cancer-related fatigue (CRF) is one of the most prevalent and debilitating symptoms experienced by people with cancer. It can persist for months or years after cancer therapy is completed and has a negative impact on all areas of function. Meaningful evidence-based treatment options for CRF are extremely limited and finding safe, inexpensive, and effective interventions for managing this distressing symptom are urgently needed. Basic research on neural-immune interactions has shown that pro-inflammatory cytokines can cause potent changes in behavior including reduced activity, fatigue, and decreased social behavior. Furthermore, research over the last decade has correlated more debilitating levels of CRF with increased levels of pro-inflammatory cytokines. Thus, investigation of therapeutic modalities that may decrease pro-inflammatory cytokines, decrease hsCRP, and increase anti-inflammatory cytokines in the setting of CRF represents a plausible target for intervention. Massage therapy is one of the fastest growing alternative therapies and has a high rate of acceptance for symptom management among cancer patients. Massage has been shown in smaller studies with cancer patients to modulate the immune system. Moreover, massage has been demonstrated to significantly decrease pro-inflammatory cytokines in normal subjects. There are no published randomized controlled trials examining either the role of massage as an intervention primarily for CRF or investigating its anti-inflammatory effects as a mechanism for its hypothesized improvement in CRF. This proposal investigates the effects of massage therapy on CRF among a homogenous group of breast cancer survivors. Our primary hypothesis is that Swedish Massage Therapy (SMT) will decrease CRF compared to a light touch condition and wait list control. Our secondary hypothesis is that SMT will ameliorate CRF by decreasing levels of pro-inflammatory cytokines, decrease hsCRP, and increasing anti-inflammatory cytokines. Our main exploratory hypothesis is that a decrease in CRF will increase quality of life among cancer survivors.

描述（由申请人提供）：如今仅在美国就有大约 1200 万癌症幸存者，人们越来越关注癌症治疗后的生活质量。癌症相关疲劳 (CRF) 是癌症患者最普遍、最令人衰弱的症状之一。它可以在癌症治疗完成后持续数月或数年，并对所有功能领域产生负面影响。针对 CRF 的有意义的循证治疗方案极其有限，迫切需要找到安全、廉价且有效的干预措施来控制这种令人痛苦的症状。关于神经免疫相互作用的基础研究表明，促炎细胞因子可以引起行为的有效改变，包括活动减少、疲劳和社交行为减少。此外，过去十年的研究已将更严重的 CRF 水平与促炎细胞因子水平的增加联系起来。因此，在 CRF 背景下研究可能减少促炎细胞因子、降低 hsCRP 和增加抗炎细胞因子的治疗方式代表了一个合理的干预目标。按摩疗法是发展最快的替代疗法之一，在癌症患者中对症状管理的接受度很高。针对癌症患者的小型研究表明，按摩可以调节免疫系统。此外，按摩已被证明可以显着减少正常受试者的促炎细胞因子。目前还没有已发表的随机对照试验来检验按摩作为主要针对 CRF 的干预措施的作用，或研究其抗炎作用作为假设的 CRF 改善机制。该提案调查了按摩疗法对同质乳腺癌幸存者群体中 CRF 的影响。我们的主要假设是，与轻微触摸条件和等待名单控制相比，瑞典式按摩疗法 (SMT) 会降低 CRF。我们的次要假设是，SMT 将通过降低促炎细胞因子水平、降低 hsCRP 和增加抗炎细胞因子来改善 CRF。我们的主要探索性假设是 CRF 的降低将提高癌症幸存者的生活质量。

项目成果

Model structure for protocol adherence utilizing a manualized therapeutic massage intervention.

利用手动治疗按摩干预来遵守协议的模型结构。

• DOI: 10.1515/jcim-2016-0118
• 发表时间: 2018
• 期刊: Journal of complementary & integrative medicine
• 作者: Larson,ErikaR;Kinkead,Becky;Edwards,SherryA;Schettler,PamelaJ;Dunlop,BoadieW;Rakofsky,JeffreyJ;Rapaport,MarkH
• 通讯作者: Rapaport,MarkH

Massage therapy decreases cancer-related fatigue: Results from a randomized early phase trial.

• DOI: 10.1002/cncr.31064
• 发表时间: 2018-02-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Kinkead B;Schettler PJ;Larson ER;Carroll D;Sharenko M;Nettles J;Edwards SA;Miller AH;Torres MA;Dunlop BW;Rakofsky JJ;Rapaport MH
• 通讯作者: Rapaport MH