NCIC Clinical Trials Group - Canadian Collaborating Clinical Trials Network

NCIC 临床试验小组 - 加拿大临床试验合作网络

• 批准号: 8605966
• 负责人: Janet Ellen Dancey
• 金额: $ 331.45万
• 依托单位: QUEEN'S UNIVERSITY AT KINGSTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-06 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8605966
• 关键词: Adult; Advisory Committees; American; Canada; Cancer Biology; Cancer Patient; Cancer Therapy Evaluation Program; Child; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Design; Clinical Trials Network; Collaborations; Commit; Communities; Conduct Clinical Trials; Cooperative Group Program; Data Analyses; Development; Developmental Process; Disease; Ensure; Environment; Evaluation; Expenditure; Goals; Health; Image; Individual; Information Technology; Knowledge; Lead; Leadership; Malignant Neoplasms; Methodology; Mission; Modality; Molecular; Morbidity - disease rate; National Cancer Institute of Canada; National Cancer Institute of Canada Clinical Trials Group; Oncology Group; Outcome; Patients; Phase; Policies; Postdoctoral Fellow; Process; Protocols documentation; Randomized; Recording of previous events; Reporting; Research; Research Infrastructure; Research Personnel; Retrieval; Scientific Advances and Accomplishments; System; Translational Research; United States; anticancer research; base; cancer cell; cancer prevention; cancer type; carcinogenesis; data management; data sharing; design; expectation; experience; health care delivery; improved; meetings; mortality; patient population; programs; public health relevance; therapeutic target; treatment trial

DESCRIPTION (provided by applicant): The overall goal of the NCTN Program is to "conduct definitive, randomized, late phase clinical treatment trials and advanced imaging trials across a broad range of diseases and diverse patient populations, as well as development efforts preliminary to those trials, as part of the NCI's overall clinical research program for adults and children with cancer." The mission of the NCIC CTG is "to develop and conduct clinical trials aimed at improving the treatment and prevention of cancer with the ultimate goal of reducing morbidity and mortality from this disease." The overlaps of these goals create a rationale for a Canadian Collaborating Clinical Trials Network. This rationale is further supported by similar societal expectations by Canadians and Americans for improved health outcomes and similar respective strategic priorities of NCIC CTG and the NCTN that recognize that new understandings of the molecular basis of carcinogenesis have the potential to advance health care delivery, including through improved therapeutic targeting of the cancer cell and better identification of therapies for individual patients. The specific objectives of NCIC CTG to collaborate with NCI/CTEP and US-based groups, through its newly-formed National Clinical Trials Network Program, to develop new Intergroup trials under NCIC CTG leadership and to ensure more rapid accrual to trials led by US-based groups, to enhance the scientific content of these trials through evaluation of additional endpoints and to contribute to new understandings of clinical trial methodology and analysis. This aim is facilitated by NCIC CTG's unique information technology supports and understandings of the Canadian regulatory environment. The aims of this application are to facilitate Canadian leadership of NCTN trials that represent value from the perspective of expenditure of U.S. federal dollars and to conduct U.S.-led NCTN trials in Canada.

描述（由申请人提供）：NCTN 计划的总体目标是“针对广泛的疾病和不同的患者群体进行明确的、随机的后期临床治疗试验和高级影像学试验，以及这些试验的初步开发工作”。试验，作为 NCI 针对成人和儿童癌症患者的整体临床研究计划的一部分。” NCIC CTG 的使命是“开发和开展旨在改善癌症治疗和预防的临床试验，最终目标是降低该疾病的发病率和死亡率。”这些目标的重叠为加拿大临床试验合作网络奠定了基础。这一基本原理得到了加拿大人和美国人对改善健康结果的类似社会期望以及 NCIC CTG 和 NCTN 各自相似的战略重点的进一步支持，这些战略重点认识到对致癌分子基础的新认识有可能促进医疗保健的提供，包括通过改善癌细胞的治疗靶向并更好地识别个体患者的治疗方法。 NCIC CTG 的具体目标是通过其新成立的国家临床试验网络计划与 NCI/CTEP 和美国团体合作，在 NCIC CTG 的领导下开发新的组间试验，并确保更快地积累由美国主导的试验。基础小组，通过评估其他终点来增强这些试验的科学内容，并促进对临床试验方法和分析的新理解。日产中国三峡集团独特的信息技术支持和对加拿大监管环境的理解促进了这一目标的实现。该申请的目的是促进加拿大对 NCTN 试验的领导，这些试验从美国联邦美元支出的角度来看具有价值，并在加拿大进行美国主导的 NCTN 试验。