Cancer Center Support Grant

癌症中心支持补助金

• 批准号: 8705401
• 负责人: NANCY ELLEN DAVIDSON
• 金额: $ 498.54万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-10 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8705401
• 关键词: Behavioral; Cancer Burden; Cancer Center; Cancer Center Support Grant; Caring; Catchment Area; Clinical; Clinical Investigator; Clinical Trials; Communities; Comprehensive Cancer Center; Development; Diagnosis; Direct Costs; Disease; Early Detection Research Network; Education; Epidemiology; Evaluation; Extramural Activities; Funding; Goals; Grant; Head and neck structure; Health system; Laboratories; Lead; Leadership; Lung; Malignant Neoplasms; Monitor; National Cancer Institute; Patients; Peer Review; Pennsylvania; Phase; Prevention; Protocols documentation; Publications; Request for Applications; Research; Research Personnel; Research Support; Skin Cancer; System; Universities; University of Pittsburgh Cancer Institute; Work; anticancer research; cancer care; cancer prevention; clinical care; improved; member; neoplasm registry; outreach; programs

DESCRIPTION (provided by applicant): This Cancer Center Support Grant application from the University of Pittsburgh Cancer Institute, an NCI-designated Comprehensive Cancer Center, seeks support for years 22-26. The UPCI is organized as a matrix center that integrates cancer research, clinical care, and cancer outreach across the University of Pittsburgh and its affiliated health system, UPMC. The UPCI includes 348 members from 37 academic departments who have come together to work to reduce the burden of cancer through cancer-related basic, translational, clinical, behavioral, epidemiological, prevention and control research. Total annual extramural cancer research funding (direct costs) to UPCI was $109.5 million (peer-reviewed $95M, non-peer-reviewed $14.5M) on October 1, 2009 of which $42.5M was received from the National Cancer Institute. The commitment of UPCI to transdisciplinary cancer research is exemplified by the fact that its members lead three SPORE grants (lung, head and neck, and skin cancers), eight cancer-focused P01s, two Early Detection Research Network grants, and a phase I U01. The impact of the cancer research driven by UPCI and its members can be seen in the more than 4,400 unique publications by UPCI investigators from 2004-2009 of which 45% represent collaborative efforts (17% intra-programmatic, 20% inter-programmatic, and 8% both). The integration of investigators at the main University of Pittsburgh campus with clinicians from a unique clinical care network encompassing about 40 UPMC community cancer centers across Western Pennsylvania has enabled enhanced patient access to clinical trials throughout our catchment area in a highly productive way. In 2008 a total of 11,484 patients were entered in the cancer registry. During that same year 1,158 and 2,508 patients entered interventional and non-interventional clinical trials, respectively. It is noteworthy that in 2008 30% of accruals to interventional trials were to investigator-initiated trials and 40% of accruals to interventional trials took place at UPMC community cancer centers. This renewal application requests support for twelve scientific research Programs, fifteen Shared Facilities, Protocol-Specific Research Support, Protocol Review and Monitoring System, planning and evaluation activities, developmental funds, senior leadership, staff investigators, and administration.

描述（由申请人提供）：该癌症中心支持拨款申请匹兹堡大学癌症研究所（NCI指定的综合癌症中心）寻求22 - 26年的支持。 UPCI被组织为矩阵中心，该中心整合了匹兹堡大学及其附属卫生系统UPMC的癌症研究，临床护理和癌症外展。 UPCI包括来自37个学术部门的348名成员，他们聚集在一起，通过与癌症相关，转化，临床，行为，流行病学，预防和控制研究来减轻癌症的负担。 2009年10月1日，UPCI的年度年度年度校外研究资金（直接费用）为1.095亿美元（经过同行评审的9500万美元，非派遣经过1450万美元），其中4250万美元从国家癌症研究所获得。 UPCI对跨学科癌症研究的承诺得到了以下事实的例证：其成员领导三个孢子补助（肺，头颈和皮肤癌），八个以癌症为中心的P01，两个早期的检测研究网络补助和I期U01。 UPCI研究人员在2004年至2009年的4400多个独特出版物中可以看到由UPCI及其成员驱动的癌症研究的影响，其中45％代表了协作努力（17％的程序内部编程，跨编程间为20％，相机跨编程间为20％，两者兼有8％）。匹兹堡主要校园的研究人员与来自独特的临床护理网络的临床医生在宾夕法尼亚州西部的大约40个UPMC社区癌症中心的临床医生的整合，这使得以高生产力的方式增强了整个流域的患者进入我们集水区的临床试验。 2008年，总共有11,484名患者进入癌症注册表。同年，有1,158和2,508例患者分别进行了介入和非介入临床试验。值得注意的是，在2008年，有30％的介入试验应进行的应计试验，是研究者发起的试验，而40％的应计介入介入进行介入试验进行介入试验。此续签应用要求为十二个科学研究计划，十五个共享设施，特定于协议的研究支持，协议审查和监测系统，计划和评估活动，发展基金，高级领导，员工调查人员和行政管理提供支持。