Development of breakthrough intra-operative detector and imaging system for parat

开发突破性的术中探测器和成像系统

• 批准号: 8715217
• 负责人: Anita Mahadevan-Jansen
• 金额: $ 59.16万
• 依托单位: ANASYS INSTRUMENTS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8715217
• 关键词: Accidental Injury; Address; Adverse effects; Advocate; Calcium; Data; Detection; Development; Diffuse; Disease; Endocrine; Engineering; Excision; Eye; Fatty acid glycerol esters; Fluorescence; Goals; Goggles; Health; Healthcare Systems; Homeostasis; Hormones; Hypocalcemia result; Hypoparathyroidism; Image; Incidence; Injury; Lasers; Lead; Length of Stay; Lighting; Lymph; Lymph Node Dissections; Lymph Node Involvement; Malignant Lymph Node Neoplasm; Malignant Neoplasms; Malignant neoplasm of thyroid; Morbidity - disease rate; Neck; Neck Dissection; Neoplasm Metastasis; Operative Surgical Procedures; Parathyroid gland; Parathyroidectomy; Patients; Phase; Procedures; Production; Protocols documentation; Relative (related person); Reporting; Research; Safety; Scanning; Small Business Technology Transfer Research; Spectrum Analysis; Surgeon; System; Techniques; Technology; Thyroid Gland; Thyroidectomy; Time; Tissues; Touch sensation; Universities; Vascularization; Work; base; cancer cell; cancer surgery; cost; design; detector; imaging detector; lymph nodes; prevent; prophylactic; prototype

Project Summary / Abstract There are 4 parathyroid glands in the neck and they are responsible for the production of parathyroid hormone which maintains calcium homeostasis throughout the body. They are difficult to identify relative to the other tissues in the neck such as lymph nodes, fat, thyroid etc. This has resulted in the incidence of accidental parathyroid removal ranging from 8% to 19% of patients undergoing total thyroidectomy . Damage to the parathyroid gland(s) can cause hypoparathyroidism and hypocalcemia resulting in serious and deleterious side effects. There are 3 different surgery procedures in the neck region where a key part of surgery protocol is for the surgeon to visually identify the parathyroid clearly to avoid accidental injury and removal. These are Thyroidectomy (involving partial or complete removal of thyroid), Parathyroidectomy (involving removal of one or more parathyroid glands) and modified Neck Dissection (involving removal of lymph nodes in neck into which cancer has spread). In a recent discovery, the PI Prof. Mahadevan-Jansen's group at Vanderbilt University reported for the first time the breakthrough finding that the Parathyroid Gland has a unique autofluorescence signature in the NIR under illumination at 785nm. The Phase 1 research demonstrated a prototype platform based on this technology that could do point detection and imaging. The specific aims of this proposal is to build upon that work and it seeks to a) Develop a product that can function in two modes: ¿ A point detection mode that can be used to confirm if a candidate tissue is parathyroid or not ¿ An imaging mode that can be used to look at a region to guide the surgeon to then using the point detection mode to confirm b) To investigate the use of the auto-fluorescence technology to assess lymph nodes intra-operatively for cancer metastases. c) To detect parathyroid vascularization via diffuse reflectance spectroscopy

项目摘要 /摘要 脖子上有4个甲状旁腺，它们负责产生甲状旁腺本） 维持整个体内钙稳态。他们很难识别相对于另一个 颈部的组织，例如淋巴结，脂肪，甲状腺等。这导致了意外事件 甲状旁腺切除率从8％到19％的甲状腺切除术范围为19％。损坏 甲状旁腺可引起甲状旁腺功能低下和低钙症，导致严重和缺乏 副作用。 颈部区域有3种不同的手术程序，其中手术方案的关键部分是针对 外科医生在视觉上清楚地识别甲状旁腺，以避免意外伤害和清除。这些都是 甲状腺切除术（涉及部分或完全去除甲状腺），甲状旁腺切除术（涉及去除一个 或更多的甲状旁腺）和修饰的颈部解剖（涉及将颈部淋巴结清除到颈部中 哪些癌症已经扩散）。 在最近的发现中，范德比尔特大学的PI Mahadevan-Jansen教授报告 时间突破发现甲状旁腺在NIR中具有独特的自动荧光签名 在785nm的照明下。第1阶段研究证明了基于此的原型平台 可以进行点检测和成像的技术。 该提议的具体目的是在这项工作的基础上进行，并试图 a）开发可以在两种模式下运行的产品： »可用于确认候选组织是否为甲状旁腺的点检测模式 »一种成像模式，可用于查看一个区域，以指导外科医生使用 点检测模式确认 b）调查使用自动荧光技术来评估术中淋巴结的 癌症转移。 c）通过扩散反射光谱检测甲状旁腺血管化