Receptor Function

受体功能

基本信息

批准号：
8577250
负责人：
DANA E SELLEY
金额：
$ 13.55万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8577250
关键词：
Absence of pain sensation Adverse drug effect Affective Affinity Animals Autoradiography Behavior Behavioral Binding Binding Sites Biological Assay Brain Brain region Calcium Cell Line Cell model Cell physiology Cells Cellular Morphology Cocaine Colon Comorbidity Complement Constipation Cyclic AMP Data Development Dissection Dopamine Receptor Drug abuse Endocannabinoids Exhibits Fluorescence Funding Future GTP-Binding Proteins Gastrointestinal Transit Gene Expression Generations Goals Grant HIV Histology Immunohistochemistry Instruction Investigation Lead Ligand Binding Ligands Maps Marijuana Measurement Mediating Methods Microscopic Mission Molecular Molecular Structure Neuroanatomy Neuroglia Neurons Nicotine Nucleus Accumbens Opiates Opioid Opioid Receptor Pain Pathway interactions Pharmacology Phosphoproteins Physiological Population Postdoctoral Fellow Prefrontal Cortex Primary Cell Cultures Publications Reader Receptor Activation Receptor Signaling Reporter Genes Research Research Personnel Resources Rewards Role Second Messenger Systems Services Signal Transduction Signaling Protein Site Structure-Activity Relationship Students System Techniques Time Tissues Training Transgenic Organisms Ventral Tegmental Area Virginia arrestin B base brain cell cannabinoid receptor cell type cellular imaging chemokine receptor dopamine transporter drug mechanism drug of abuse gastrointestinal system ileum innovation insight interest neurochemistry new therapeutic target novel opiate tolerance radioligand receptor receptor binding receptor density receptor function receptor internalization receptor-mediated signaling relating to nervous system screening second messenger small molecule stimulant abuse trafficking

项目摘要

PROJECT SUMMARY (See instructions): The primary mission of this core will be to provide services, facilities and training to facilitate the study of receptors or related small molecule targets, such as transporters, with a goal of enhancing research in drug abuse and related co-morbidities. Services will include measurement of receptor binding, receptor localization, receptor signaling (with a primary focus on GPCRs, although not limited to GPCRs), receptor trafficking and receptor-protein interaction. The core will also perform moderate-throughput ligand screening to determine small molecular structure-activity relationships at particular target sites. The core will also provide relevant tissue preparative functions, such as tissue sectioning and primary cell culture development, for core studies. Finally the core will provide relevant training for PIs, students or post-doctoral fellows.

项目摘要（请参阅说明）：该核心的主要任务是提供服务，设施和培训，以促进受体或相关小分子靶标（例如转运蛋白）的研究，以增强对药物滥用和相关合并症的研究。服务将包括测量受体结合，受体定位，受体信号传导（主要关注GPCR，尽管不限于GPCR），受体运输和受体 - 蛋白质相互作用。核心还将执行中等通讯配体筛选，以确定特定目标位点的小分子结构活性关系。核心也将为核心研究提供相关的组织制备功能，例如组织切片和原发性细胞培养的发育。最后，核心将为PI，学生或博士后研究员提供相关的培训。