Quantitative breast cancer risk index from routine 3-D imaging

常规 3D 成像定量乳腺癌风险指数

基本信息

批准号：
8697025
负责人：
SRINIVASAN VEDANTHAM
金额：
$ 17.67万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8697025
关键词：
3-Dimensional Age Agreement Algorithms American College of Radiology Area Breast Breast Cancer Detection Breast Cancer Risk Factor Cancer Prognosis Caring Categories Clinical Clinical Research Custom Data Development Diagnostic Digital Breast Tomosynthesis Disease Ensure Evaluation FDA approved Feasibility Studies Federal Government Future Health Image Image Analysis Individual Information Systems Intervention Lesion Magnetic Resonance Imaging Malignant Neoplasms Mammographic Density Mammography Manufacturer Name Masks Measurement Measures Meta-Analysis Methods Metric Modeling Mutation Organ Pattern Population Preparation Recording of previous events Regimen Relative Risks Reporting Research Retrospective Studies Risk Risk Assessment Risk Factors Simulate Site Statutes and Laws System Techniques Texture Three-Dimensional Image Three-Dimensional Imaging Tissues United States Vendor Woman Work base breast density cancer risk clinically significant design high risk imaging modality improved indexing malignant breast neoplasm radiologist reconstruction screening simulation tool two-dimensional

项目摘要

DESCRIPTION: This application is responsive to PA-10-026, "Development, Application, and Evaluation of Prediction Models for Cancer Risk and Prognosis (R21)". This research is disease and organ-specific and is aimed at developing and validating an accurate method for determining breast density, a known risk factor for breast cancer. Developing an accurate method for estimating breast density is essential to ensure the accuracy of prediction models for cancer risk and prognosis. Several studies have shown the association between breast density and breast cancer risk. A meta-analysis observed that the relative risk was ~4.7 for women with greater than 75% fibroglandular content compared to those with less than 5% fibroglandular content. Breast density is now considered the third highest risk factor in terms of relative risk after age and BRCA mutation. Recognizing the significance of breast density as a risk factor and the reduced sensitivity of mammography for women with dense breasts, several states now regulate that a woman undergoing screening mammography is informed of her breast density. In the United States, breast density is reported as per the American College of Radiology, Breast Imaging Reporting and Data System by the interpreting Radiologist that uses four categories. It is has been shown that agreement between Radiologists for such categorical assignment is only moderate. Hence, there is a need to develop accurate quantitative techniques for estimating breast density. While some studies use quantitative estimates of breast density from the projected area of the breast, often referred to as percent mammographic density, recent research has shown that volumetric estimates of breast density are more accurate predictors of breast cancer risk. In this research, we propose to develop and evaluate a quantitative algorithm that serves as a tool for the estimation of volumetric breast density and associated measures based on parenchymal texture analysis using 3-D images provided by digital breast tomosynthesis (DBT). At least one DBT system manufacturer has obtained FDA-approval for routine clinical use and several manufacturers are working towards FDA approval. Hence, the developed quantitative tool will be designed to be compatible with DBT systems from multiple vendors, facilitating its widespread use for clinical studies. This is particularly important for studies where image data are pooled from multiple sites that may use DBT systems from different vendors. The specific aims of this research include developing the quantitative tool, evaluating its quantitative accuracy, and conducting a feasibility study aimed a demonstrating its accuracy in a clinical population with breast MRI serving as the truth. The validated 3-D imaging based quantitative tool can be used in future studies to accurately determine the cancer risk associated with breast density, to assess the effect of pharmacologic intervention on breast density and cancer risk, and to develop personalized breast cancer screening regimens.

描述：此应用对PA-10-026的反应，“癌症风险和预后预测模型的开发，应用和评估（R21）”。这项研究是疾病和特定器官特异性的，旨在开发和验证确定乳腺密度的准确方法，乳腺癌是乳腺癌的已知危险因素。开发一种估计乳房密度的准确方法对于确保预测模型的癌症风险和预后的准确性至关重要。几项研究表明，乳腺癌与乳腺癌风险之间的关联。一项荟萃分析观察到，与纤维状含量小于5％的纤维含量相比，纤维含量大于75％的女性的相对风险约为4.7。现在，乳房密度被认为是年龄后的相对风险和BRCA突变的第三高风险因素。认识到乳房密度作为危险因素的重要性以及乳房X线摄影对乳房密集的女性的敏感性降低，现在有几个州调节接受乳房X线摄影的女性被告知她的乳房密度。在美国，根据使用四类的解释放射科医生，根据美国放射学，乳房成像报告和数据系统的乳房密度据报道。已经表明，放射科医生在这种分类分配方面的一致性只是中等的。因此，需要开发准确的定量技术来估计乳房密度。尽管一些研究使用乳房预测区域的乳房密度的定量估计，通常称为乳房X线摄影密度百分比，但最近的研究表明，乳腺癌的体积估计值更准确地预测了乳腺癌风险。在这项研究中，我们建议开发和评估一种定量算法，该算法是使用数字乳房合成（DBT）提供的3-D图像基于实质纹理分析来估算体积乳房密度和相关措施的工具。至少有一家DBT系统制造商已获得了常规临床使用的FDA批准，并且几家制造商正在努力批准FDA。因此，开发的定量工具将设计为与来自多个供应商的DBT系统兼容，从而促进了其在临床研究中的广泛使用。这对于从多个可能使用来自不同供应商的DBT系统的站点汇总的图像数据的研究尤其重要。这项研究的具体目的包括开发定量工具，评估其定量准确性，并进行可行性研究，目的是证明其在具有乳房MRI的临床人群中的准确性。可以在未来的研究中使用经过验证的基于3-D成像的定量工具，以准确确定与乳房密度相关的癌症风险，评估药理学干预对乳腺密度和癌症风险的影响，并开发个性化的乳腺癌筛查治疗方案。