EXPANDING WNPRC RESOURCES FOR AIDS-RELATED RESEARCH

扩大 WNPRC 艾滋病相关研究资源

• 批准号: 8358233
• 负责人: Joseph W. Kemnitz
• 金额: $ 18.95万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358233
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Affect; Animal Housing; Animal Model; Animals; Applications Grants; Area; Funding; Genetic; Goals; Grant; HIV; Housing; Immune response; Immunologic Deficiency Syndromes; Macaca; Mauritius; National Center for Research Resources; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Research Personnel; Resources; SIV; Source; Specimen; System; United States National Institutes of Health; Virus; Water; Wisconsin; cost; experience; novel; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: The primary objectives of the SIV program at the Wisconsin National Primate Research Center (WNPRC) are to understand the attributes of effective anti-immunodeficiency virus immune responses, develop novel AIDS vaccines, and expand the HIV animal model to include the unique genetic attributes of cynomolgus macaques (Macaca fasicularis) from Mauritius. The WNPRC is experiencing a critical shortage of animal housing which directly affects advances in AIDS research. Our current SIV housing facility was near capacity and will be insufficient for our immediate needs. The primary goal of this G20 grant proposal was to renovate an existing specimen storage area, which is adjacent to the existing SIV housing area, into three new animal housing rooms. The project, completed during this reporting period, included sufficient caging and an automatic watering system to equip these new animal rooms. The completion of this renovation has provided the critical space necessary for the expansion of the SIV program at the WNPRC and for the investigators to continue their ground-breaking research.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目标：威斯康星国家灵长类动物研究中心 (WNPRC) SIV 项目的主要目标是了解有效的抗免疫缺陷病毒免疫反应的属性，开发新型艾滋病疫苗，并扩展 HIV 动物模型以包含独特的遗传属性来自毛里求斯的食蟹猴（Macaca fasularis）。 WNPRC 的动物圈舍严重短缺，这直接影响了艾滋病研究的进展。我们目前的 SIV 住房设施已接近满负荷，不足以满足我们的即时需求。 这项 G20 赠款提案的主要目标是将毗邻现有 SIV 居住区的现有标本存储区改造成三个新的动物居住室。该项目于本报告期内完成，包括足够的笼舍和自动浇水系统，以装备这些新的动物房。此次改造的完成为 WNPRC 的 SIV 项目的扩展以及研究人员继续其开创性研究提供了必要的关键空间。