POST-EXPOSURE MONITORING OF LENTIVIRUS-INFECTED MACAQUES

慢病毒感染猕猴的暴露后监测

• 批准号: 8357594
• 负责人: DAVID M ANDERSON
• 金额: $ 37.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357594
• 关键词: Animals; Autopsy; Blood; Chemistry; Disease; Drug Evaluation; Event; Funding; Grant; HIV; Macaca; Monitor; National Center for Research Resources; Pathogenesis; Pathology; Primates; Principal Investigator; Protocols documentation; Research; Research Infrastructure; Resources; SIV; Serologic tests; Serum; Source; Subfamily lentivirinae; T-Lymphocyte Subsets; United States National Institutes of Health; Vaccines; Viral; Wing; cost; design; immunosuppressed

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is designed to act as a holding and resource project for animals that have been infected with SIVor HIV that are no longer required on the original project. The animals will be maintained in BSL-2/3 facilities, either in the I- Wing or at the PFS. They will be monitored clinically to help define the natural pathogenesis of the disease. No research will be done on this project; however, the animals may be reassigned to other projects to serve as subjects in experimental drug evaluations, pathogenesis studies, vaccine studies, or studies requiring immunosuppressed and/or SIV/HIV-viremic animals. Blood will be drawn every 2-3 months for viral isolation, serology, CBC, serum chemistry, and T- cell subset analysis. In the event that an animal should become unresponsive to treatment or should die, a complete necropsy will be performed using the standard SIV/HIV pathology protocol.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目旨在作为控股和资源项目 已感染 SIV 或 HIV 且不再需要的动物 在原来的项目上。这些动物将被饲养在 BSL-2/3 中 设施，无论是在 I 翼还是在 PFS。他们将受到监控 临床上有助于确定疾病的自然发病机制。不 将对这个项目进行研究；然而，这些动物可能是 重新分配到其他项目，作为实验药物的受试者 评估、发病机制研究、疫苗研究或需要的研究 免疫抑制和/或 SIV/HIV 病毒血症动物。 每2-3个月抽血一次，用于病毒分离、血清学、CBC、 血清化学和 T 细胞亚群分析。如果有动物 应该对治疗没有反应或者应该死亡，完整的尸检 将使用标准 SIV/HIV 病理学方案进行。