DELINEATION OF MULTIPLE SUBPOPULATIONS OF NATURAL KILLER CELLS IN MONKEYS

猴子自然杀伤细胞多个亚群的划分

• 批准号: 8357919
• 负责人: R. PAUL JOHNSON
• 金额: $ 19.39万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357919
• 关键词: Animals; Funding; Grant; Homing; Infection; Manuscripts; Monkeys; National Center for Research Resources; Natural Killer Cells; New England; Primates; Principal Investigator; Publishing; Research; Research Infrastructure; Resources; SIV; Source; United States National Institutes of Health; base; cost; cytotoxic; lymph nodes

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Over the last year we completed our analyses of changes in NK cells in SIV-infected animals and published two manuscripts. These results show that SIV infection upregulates cytotoxic activity of NK cells and shifts homing from lymph nodes to the gut.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 去年，我们完成了对 SIV 感染动物 NK 细胞变化的分析，并发表了两篇手稿。 这些结果表明，SIV 感染上调 NK 细胞的细胞毒活性，并将归巢从淋巴结转移到肠道。