Integrating innate and adaptive pathways in vaccine responses

将先天和适应性途径整合到疫苗反应中

基本信息

批准号：
8707655
负责人：
JEFFREY Victor RAVETCH
金额：
$ 243.54万
依托单位：
ROCKEFELLER UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8707655
关键词：
Adjuvant Age Amino Acid Sequence Anti-Inflammatory Agents Anti-inflammatory Antibodies Antigen-Antibody Complex Antigens Award Biological CD209 gene Cells Clinical Sciences Collaborations Communicable Diseases Complex Coupling Data Dendritic Cells Dependence Development Disease Evolution FDA approved Family Fc Receptor Fc domain Fucose Funding Galactose Generations Goals Helper-Inducer T-Lymphocyte Hepatitis C virus Human Humoral Immunities Immune response Immunity Immunization Immunoglobulin G Immunoglobulins Immunologic Adjuvants Immunology Infectious Agent Inflammatory Integration Host Factors Investigation Laboratories Link Maintenance Mediating Mediator of activation protein Medical Microbe Modification Molecular Monoclonal Antibody Therapy Mus Nature Pathway interactions Peptide Sequence Determination Phagocytosis Polysaccharides Production Regulation Research Research Infrastructure Research Personnel Research Project Grants Role Route Sampling Serum Sialic Acids Specificity Study models System T-Lymphocyte Testing Translational Research Universities University Hospitals Vaccination Vaccine Adjuvant Vaccine Design Vaccines antibody-dependent cell cytotoxicity base cytokine defined contribution design member monocyte novel novel vaccines programs receptor research study response vaccine efficacy virus identification volunteer

项目摘要

DESCRIPTION (provided by applicant): The goal of this program is to perform directed investigations into the evolution of lasting, protective Immune responses in humans in order to better understand the requirements of effective vaccines and adjuvants. This application is submitted to obtain funding for a Cooperative Center on Human Immunology at The Rockefeller University. Our program is highly integrated and is based on long-term, productive collaborations between the PIs on defining underlying principles of human immunology, utilizing the infrastructure of the Rockefeller University Hospital, the Zanvil Cohn Vaccine Center and the Rockefeller University Clinical and Translational Science Award (CTSA). The proposed research projects are designed as hypothesis-testing, mechanistic studies, examining novel aspects of the activation and regulation of human immune responses in the context of vaccination against infectious disease. The participating investigators are pioneers in identifying and characterizing basic mechanisms of the human immune response, having contributed to the initial characterizations of the dendritic cell, the diversity of IgG antibody effector functions ad description of Fc receptors as mediators of immunity, the development of the first models for study of the hepatitis C virus and the Identification of multiple HCV receptors. While significant progress in basic immunology research over the last three decades has resulted in numerous medical advances, a much more substantial understanding of coordinated molecular mechanisms involved in eliciting Immunity will be required to enable judicious vaccine design, particularly for diseases for which no vaccines currently exits. The objective of this proposal is o draw on the broad expertise in immunity and infectious diseases within the collaborating laboratories to define the contributions of critical components, such as dendritic cells, T follicuar helper cells, monocytes and immune complexes in the generation and maintenance of effective immune responses to infectious agents.

描述（由申请人提供）：该计划的目的是对人类持久，保护性免疫反应的演变进行指导调查，以便更好地了解有效的疫苗和辅助因素的要求。该申请提交以获得洛克菲勒大学人类免疫学合作中心的资金。我们的计划是高度整合的，并且基于PI之间的长期富有成效的合作，以定义人类免疫学的基本原理，利用洛克菲勒大学医院的基础设施，Zanvil Cohn疫苗中心和洛克基菲勒大学临床和转换科学奖（CTSA）。拟议的研究项目被设计为假设检验，机械研究，研究了针对感染疾病的疫苗接种背景下激活和调节人类免疫反应的新方面。参与的调查人员是确定的先驱并表征了人类免疫反应的基本机制，促进了树突状细胞的初始特征，IgG抗体效应子功能的多样性AD FC受体作为免疫力的介体的描述，开发用于研究肝炎病毒的第一个模型以及多个HCV受体的鉴定。尽管在过去的三十年中，基本免疫学研究的重大进展导致了许多医学进展，但需要对参与引发免疫的协调分子机制有更深刻的了解才能实现明智的疫苗设计，尤其是对于目前没有疫苗的疾病。该提案的目的是o借用协作实验室内的免疫和传染病的广泛专业知识，以定义关键组件的贡献，例如树突状细胞，T Follicuar助手细胞，单核细胞和免疫复合物，在产生和维持有效免疫反应中对感染性药物的有效免疫反应。