Establishing Infrastructure for Prevention of familial AD in Mexico

在墨西哥建立预防家族性 AD 的基础设施

• 批准号: 8743128
• 负责人: JOHN M RINGMAN
• 金额: $ 4.8万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-05-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8743128
• 关键词: Alzheimer disease prevention; Alzheimer' s Disease; Attitude; Biochemical; Biological Markers; Caring; Cities; Clinical; Clinical Trials; Cognitive; Collaborations; Country; Dementia; Development; Diagnosis; Disease; Early Onset Familial Alzheimer' s Disease; Education; Elderly; Family; Family Physicians; Family member; Funding; Genetic; Genetic screening method; Goals; Health; Health Professional; Human Resources; Image; Income; Individual; Inherited; Institutes; Institution; International; Intervention Studies; Interview; Knowledge; Longevity; Mexican; Mexico; Mutation; Natural History; Nature; Needs Assessment; Neurologist; Neurology; Observational Study; Onset of illness; Outcome Measure; Participant; Pathology; Persons; Phase; Placebo Control; Population; Presenile Alzheimer Dementia; Prevention; Prevention strategy; Procedures; Public Health; Qualifying; Questionnaires; Registries; Research; Research Infrastructure; Research Personnel; Research Training; Risk; Running; Sampling; Series; Site; Spinal Puncture; Staging; Structure; Training; Universities; Work; autosomal dominant trait; base; familial Alzheimer disease; follow-up; improved; interest; medical specialties; meetings; mutation carrier; neurosurgery; pre-clinical; presenilin-1; presenilin-2; prevent; programs; public health relevance; success

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a growing health problem worldwide and currently available treatments are of limited efficacy. Prevention of AD may be a more relevant goal, particularly in lower and middle-income countries. Studies of AD prevention however, are challenging, in part because of the unpredictable onset of the disease in elderly individuals. Persons inheriting mutations causing fully-penetrant autosomal dominant familial AD (FAD) provide an informative and motivated population for assessing the efficacy of AD prevention strategies. The PI has been working with clinician investigators in Mexico for 10 years, characterizing multiple families with FAD due to PSEN1 or APP mutations. Multi-center collaborative efforts to perform prevention trials in preclinical persons carrying FAD mutations are underway (the Dominantly Inherited Alzheimer Network in which the PI is a site investigator and the Alzheimer Prevention Initiative) but such efforts have not reached Mexico. The capacity to perform FAD prevention trials in Mexico may be limited due to lack of understanding among families and physicians of the disease and its genetic nature as well as by the availability of infrastructure including personnel appropriately trained to perform such studies. The goal of this project is to enhance the ability of Mexican investigators to perform such studies through the following specific aims: Aim 1) Enhance local capacity to perform quality cognitive, clinical, imaging, and biochemical assessments as outcome measures for prevention trials in Mexico. This project will be the planning stage in which the possibility of exchange programs wherein health professionals from Mexico come to the UCLA to receive specialty training in dementia diagnosis, management, and research will be explored. Aim 2) Investigate attitudes towards and promote education regarding AD, genetics, FAD, and prevention trial procedures among members of families with FAD in Mexico. Aim 3) Establish a registry of persons eligible for participation in prevention trials for FAD.

描述（由申请人提供）：阿尔茨海默氏病（AD）在全球范围内越来越多，目前可用的治疗方法有限。预防广告可能是一个更相关的目标，尤其是在中低收入国家。但是，预防AD的研究是具有挑战性的，部分原因是老年人疾病的不可预测发作。遗传导致全染色剂常染色体占主导地位的家族广告（FAD）的人员为评估AD预防策略的疗效提供了信息丰富且积极进取的人群。 PI已与墨西哥的临床医生研究人员合作了10年，其特征是由于PSEN1或APP突变而导致的多个FAD家族。正在进行携带FAD突变的临床前人员进行预防试验的多中心协作努力（主要继承的阿尔茨海默氏症网络中，PI是现场调查员，而阿尔茨海默氏症预防计划），但此类努力尚未达到墨西哥。在墨西哥进行预防FAD预防试验的能力可能会受到限制，因为该疾病的家庭和医生之间缺乏了解，以及其遗传性质以及包括经过适当培训的人员进行此类研究的基础设施的可用性。该项目的目的是通过以下特定目的增强墨西哥研究人员进行此类研究的能力：目标1）提高当地能力，以作为墨西哥预防试验的结果指标，以进行质量认知，临床，成像和生化评估。该项目将是计划阶段，在该阶段中，将探索来自墨西哥的卫生专业人员来到UCLA接受痴呆诊断，管理和研究方面的专业培训的可能性。目标2）调查对墨西哥流行家庭成员中对AD，遗传学，时尚和预防试验程序的教育和促进教育的态度。目标3）建立有资格参加FAD预防试验的人的注册表。