Administration, Bioinformatics and Biostatistics Core

管理、生物信息学和生物统计学核心

• 批准号: 8744925
• 负责人: Teresa Whei-Mei Fan
• 金额: $ 13.61万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-19 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8744925
• 关键词: Advisory Committees; Annual Reports; Biochemical; Biochemical Pathway; Biochemistry; Bioinformatics; Biometry; Biostatistics Core; Budgets; Cessation of life; Collaborations; Data; Data Analyses; Data Quality; Data Set; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Early Diagnosis; Ensure; Experimental Designs; Human Resources; Ice; Imagery; Informatics; Instruction; Knowledge; Laboratories; Malignant Neoplasms; Malignant neoplasm of lung; Modeling; Non-Small-Cell Lung Carcinoma; North America; Pathway Analysis; Preparation; Protocols documentation; Quality Control; Reporting; Research Personnel; Role; Services; System; Translational Research; Universities; Validation; base; cost; data management; improved; interoperability; meetings; novel strategies; operation; outcome forecast; programs; reconstruction

In this Program Project "Systems Biochemistry in Lung Cancer: toward a mechanistic understanding of NSCLC" we aim to achieve a better understanding of the basic biochemistry of lung cancers as a prerequisite to mechanism-based reliable early detection of the disease, and to improved approaches to treatment. The role of the Administrative, Bioinformatics and Biostatistics Core is to provide overall administration and oversight to the project directors and core leaders (T. W-M. Fan, Ph.D., Project 1; J. Yan, M.D., Ph.D., Project 2; A. N. Lane, Ph.D., Project 3; R. M, Higashi, Ph.D., Core B, Analytical) on this Program Project. In addition, Biostatistics and Informatics support (leaders S. N. Rai, Ph.D. and H. N. B Moseley, Ph.D.) for the Projects will be provided through this Core. To ensure smooth interoperability of the program, the administrative core will be responsible for maintaining the budgets and cost reporting of the projects and cores as well as coordinating annual reports, regular meetings among the project personnel and the internal and external advisory committees. The primary objective of the Bioinformatics / Biostatistics portion of this core is to provide support for investigators performing translational research and Informatics for biochemical pathway reconstruction and flux modeling. The core services are matched to the needs of each project and cover a full range of services from collaboration and routine service; protocol preparation and review; development of informatics approaches to ensure interoperability; and biochemical network analysis.

在这个计划项目“肺癌的系统生物化学：对 NSCLC”我们的目标是更好地了解肺癌的基本生物化学 基于机制的可靠的疾病早期检测和改进治疗方法的先决条件 治疗。行政、生物信息学和生物统计学核心的作用是提供整体 对项目负责人和核心领导者的管理和监督（T. W-M. Fan，博士，项目 1；J. Yan， 医学博士、博士、项目2； A.N. Lane 博士，项目 3； R. M, Higashi, 博士，核心 B，分析）对此 计划项目。此外，生物统计学和信息学支持（领导者 S. N. Rai, Ph.D. 和 H. N. B Moseley 博士）的项目将通过该核心提供。为了确保顺利的互操作性 方案中，行政核心将负责维护预算和费用报告 项目和核心以及协调年度报告、项目人员之间的定期会议和 内部和外部咨询委员会。生物信息学/生物统计学的主要目标 该核心的一部分是为研究人员进行转化研究和信息学提供支持 用于生化途径重建和通量建模。核心服务与需求相匹配 每个项目并涵盖从协作到日常服务的全方位服务；协议准备 并审查；开发信息学方法以确保互操作性；和生化网络 分析。