Patient Oriented Research in Gastrointestinal Cancer Screening

以患者为导向的胃肠癌筛查研究

• 批准号: 8729312
• 负责人: PHILIP S SCHOENFELD
• 金额: $ 13.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8729312
• 关键词: Achievement; Alcohol consumption; Algorithms; Area; Award; Barrett Esophagus; Binding; Biological Markers; Blood; Body mass index; Caliber; Clinic; Clinical; Clinical Protocols; Clinical Research; Colon; Colon Carcinoma; Colonic Adenoma; Colonoscopy; Colorectal Cancer; Confocal Microscopy; Data; Databases; Detection; Development; Diagnosis; Dietary Questionnaires; Dysplasia; Endoscopy; Environment; Epidemiology; Equipment and Supplies; Esophageal Adenocarcinoma; Esophagus; Faculty; Family history of; First Degree Relative; Fluorescence; Funding; Future; Gastrointestinal tract structure; Gender; Genomics; Goals; Grant; Health Services Research; Heme Iron; Human Resources; Hyperplastic Polyp; Image; Individual; Intake; Iron; K-Series Research Career Programs; Label; Lesion; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Measures; Meat; Medical; Medicine; Mentors; Mentorship; Michigan; Mid-Career Clinical Scientist Award (K24); Molecular Weight; Mucous Membrane; National Institute of Diabetes and Digestive and Kidney Diseases; Neoplasms; Non-Steroidal Anti-Inflammatory Agents; Outcomes Research; Participant; Patients; Penetration; Peptides; Performance; Physical activity; Plasma; Practice Management; Prevalence; Principal Investigator; Protocols documentation; Public Health Schools; Publications; Race; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Screening for cancer; Study Section; Supervision; System; Techniques; Time; Tissue Banking; Tissue Banks; Tobacco use; Topical application; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Woman; adenoma; adipokines; career; clinical epidemiology; colorectal cancer screening; high risk; image registration; improved; in vivo; modifiable risk; older patient; optical imaging; patient oriented; patient oriented research; programs; screening; success; tool

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award will facilitate training GI fellows participating in a specialized Training Program in GI Epidemiology (T32-DK062708), mentoring of junior faculty applying for/completing career development awards, and performance of patient-oriented research in GI cancer screening trials funded by NIH and VA. "The best predictor of future success may be past achievement." As principal investigator and Director of the U. of Michigan Training Program in GI Epidemiology, I have successfully mentored 100% of the participants to careers in academic medicine. In our program, GI fellows complete a Master's program in Clinical Research Design and Statistical Analysis and undergo extensive mentoring and supervision from senior investigators which contributes to their successful transition to academic medicine. I also mentor junior faculty on K23, R21, and other career development awards after they complete this training program. In addition to providing protected time to mentor trainees and junior faculty, this grant will also facilitate my research career objective: identification of risk factors for GI cancer and development of more effective tools for GI cancer screening. I have successfully completed K23 and R21 grants which have led to multiple publications. Currently, I am PI of a VA-funded Center grant about the application of family history and genomic tools to improve colorectal cancer (CRC) screening, and co-investigator of a U54 grant developing in vivo biomarkers for the identification of dysplasia in the esophagus and colon during endoscopy. These on-going research projects will provide a platform for trainees and junior faculty to develop their own research. Also, the U. of Michigan provides an outstanding environment and resources, including our specialized Training Program in GI Epidemiology, our NIH-funded Michigan Clinical Research Unit, VA-funded Center of Excellence for Practice Management and Outcomes Research, and our School of Public Health's specialized Master's Programs in Clinical Epidemiology. Unfortunately, mentoring of GI fellows and junior faculty is unfunded. The current U54 and VA funding pay for research supplies, equipment, and ancillary personnel, but provides inadequate funding to protect my time for patient-oriented research and mentorship. This K24 award will provide essential support to achieve my mentorship and research goals.

描述（由申请人提供）：这项K24中级研究员奖将促进训练GI研究员参加GI流行病学专业培训计划（T32-DK062708），指导初级教师，以申请/完成职业发展奖励，并在GI癌症筛查中筛查的患者研究奖励，并通过NIH进行了gi癌筛查。 “未来成功的最佳预测指标可能是过去的成就。”作为GI流行病学的主要研究员兼美国密歇根州培训计划主任，我成功地指导了100％的参与者从事学术医学的职业。在我们的计划中，GI研究员完成了临床研究设计和统计分析的硕士课程，并接受了高级研究人员的广泛指导和监督，这有助于他们成功过渡到学术医学。在完成该培训计划后，我还在K23，R21和其他职业发展奖中指导初级教师。除了提供受保护的时间来指导学员和初级教职员工外，这笔赠款还将促进我的研究职业目标：识别胃肠道癌的危险因素以及开发更有效的GI癌症筛查工具。我已经成功完成了K23和R21赠款，这导致了多个出版物。目前，我是VA资助的中心拨款的PI，旨在应用家族史和基因组工具来改善结直肠癌（CRC）筛查，以及在体内生物标志物中开发的U54赠款者的共同申请者，以鉴定内镜检查过程中食管和结肠中发育不良的肿瘤肿瘤。这些正在进行的研究项目将为受训者和初级教师提供自己的研究的平台。此外，密歇根州提供了出色的环境和资源，包括我们在GI流行病学方面的专业培训计划，我们由NIH资助的密歇根州临床研究部门，VA资助的实践管理卓越中心和成果研究中心以及我们的公共卫生学院专业的临床流行病学专业硕士课程。不幸的是，指导GI研究员和初级教师是没有资金的。当前的U54和VA资金为研究用品，设备和辅助人员付费，但提供了不足的资金来保护我用于患者面向患者的研究和指导的时间。该K24奖将为实现我的指导和研究目标提供基本的支持。

项目成果

Real-Time Characterization of Diminutive Colorectal Polyp Histology Using Narrow-Band Imaging: Implications for the Resect and Discard Strategy.

• DOI: 10.1053/j.gastro.2015.10.042
• 发表时间: 2016-02
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Patel SG;Schoenfeld P;Kim HM;Ward EK;Bansal A;Kim Y;Hosford L;Myers A;Foster S;Craft J;Shopinski S;Wilson RH;Ahnen DJ;Rastogi A;Wani S
• 通讯作者: Wani S

Role of quality measurement in inappropriate use of screening for colorectal cancer: retrospective cohort study.

质量测量在结直肠癌筛查不当使用中的作用：回顾性队列研究。

• DOI: 10.1136/bmj.g1247
• 发表时间: 2014
• 期刊: BMJ (Clinical research ed.)
• 作者: Saini,SameerD;Vijan,Sandeep;Schoenfeld,Philip;Powell,AdamA;Moser,Stephanie;Kerr,EveA
• 通讯作者: Kerr,EveA

The impact of bowel cleansing on follow-up recommendations in average-risk patients with a normal colonoscopy.

• DOI: 10.1038/ajg.2013.243
• 发表时间: 2014-02
• 期刊: AMERICAN JOURNAL OF GASTROENTEROLOGY
• 影响因子: 9.8
• 作者: Menees, Stacy B.;Elliott, Eric;Govani, Shail;Anastassiades, Constantinos;Judd, Stephanie;Urganus, Annette;Boyce, Suzanna;Schoenfeld, Philip
• 通讯作者: Schoenfeld, Philip