Stress-induced Drinking in OEF/OIF Veterans: The Role of Combat History and PTSD

OEF/OIF 退伍军人压力诱发的饮酒：战斗史和 PTSD 的作用

基本信息

批准号：
8501133
负责人：
ANANDA B AMSTADTER
金额：
$ 29.68万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8501133
关键词：
21 year old Acute Address Adult Affect Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcohols Alleles Auditory Behavior assessment Biological Blood Pressure Blood specimen Clinical Control Groups Corticotropin Counseling Data Dependence Diagnostic Distress Emotional Event Exposure to Funding Genes Genetic Genetic Polymorphism Goals Human Hydrocortisone Incidence Individual Laboratories Laboratory Study Life Measures Mediating Military Personnel National Institute on Alcohol Abuse and Alcoholism Nature Neurosecretory Systems Participant Patient Self-Report Personality Traits Physiological Play Population Post-Traumatic Stress Disorders Preventive Intervention Procedures Psychopathology Randomized Reaction Recording of previous events Recruitment Activity Research Research Personnel Risk Role Serum Societies Stimulus Stress Testing Time Trauma Trier Social Stress Test Veterans acute stress age group alcohol research alcohol response biological adaptation to stress career combat computerized cost design distress tolerance drinking drinking behavior emerging adult experience high risk indexing meetings neglect operation prevent promoter psychologic psychological stressor public health relevance response serotonin transporter stressor

项目摘要

DESCRIPTION (provided by applicant): Military personnel exposed to combat-related traumatic events, particularly those who develop posttraumatic stress disorder (PTSD), have a higher incidence of problematic drinking. However, little is known about the relationship between trauma, PTSD, and drinking in "emerging adults" (ages 21-30 years), in spite of this age group being at highest risk of developing subsequent drinking problems. The proposed clinical laboratory project will use a three group design. The target OIF/OEF population will have no trauma exposure [Control group], combat trauma exposure without PTSD [TE group], and combat trauma exposure with PTSD [PTSD group]. The type of traumatic event exposure history included will be limited to combat- related traumatic events that are interpersonal in nature. This project will use a well-established clinical laboratory paradigm of stress induction employed by our group, the Trier Social Stress Test (TSST), to investigate the role of a history of exposure to combat trauma on reactivity to the TSST and on stress- induced voluntary drinking. Subjects will not meet diagnostic criteria for alcohol dependence. Half of each group will receive the TSST and the other half will be randomized to the no stress condition. Using subjective as well as biological indices of stress, the first specific aim examines the effect of combat trauma history on stress reactivity, using subjective, neuroendocrine, and physiological measures of stress. The second specific aim will examine the effect of combat trauma history on subsequent drinking behavior and subjective response to alcohol using established procedures in a clinical laboratory paradigm. Exploratory analyses will also be conducted to examine the correlation between combat trauma history group and subjective response to stress, and combat trauma history group and drinking. Two additional exploratory analyses will evaluate the effect of the personality trait of distress tolerance (high and low), and the effect of carrying the 'S' or the rare 'LG' allele of the 5-HTTLPR polymorphism on the stress response and on voluntary drinking following stress induction. This study will advance our understanding of the relationship between a history of combat-related traumatic events, stress, and drinking. The ultimate goal of this line of research is to identify "at risk" groups early in their drinking careers, before unhealthy drinking practices and/or dependence develop. This information has the potential to inform prevention and intervention alcohol research.

描述（由申请人提供）：暴露于与战斗有关的创伤事件的军事人员，尤其是那些患有创伤后应激障碍（PTSD）的人，饮酒的发生率更高。然而，尽管这个年龄段的人群面临随后的饮酒问题的最高风险，但对“新兴成年人”（21-30岁）的创伤，PTSD和饮酒之间的关系知之甚少。拟议的临床实验室项目将使用三个组设计。目标OIF/OEF人群将没有创伤暴露[对照组]，没有PTSD [TE组]和PTSD [PTSD组]的战斗创伤暴露。所包含的创伤事件暴露历史的类型将仅限于与人际自然界的作战相关的创伤事件。该项目将使用我们小组Trier社会压力测试（TSST）采用的良好成熟的临床实验室范围，以调查暴露于战斗创伤对TSST和压力诱导的自愿饮酒的反应性的作用。受试者将不符合酒精依赖的诊断标准。每组的一半将接收TSST，另一半将随机分配到无应力条件。使用主观和压力的生物指标，第一个特定的目的使用主观，神经内分泌和压力的生理测量来研究战斗创伤历史对应激反应性的影响。第二个特定目的将检查作战创伤历史对随后的饮酒行为和对酒精的主观反应的影响，并使用临床实验室范式中的既定程序。还将进行探索性分析，以检查战斗创伤史组与压力的主观反应与战斗创伤历史组和饮酒之间的相关性。另外两个探索性分析将评估遇险耐受性的人格特征（高和低）的影响，以及携带5-HTTLPR多态性的“ S”或罕见的“ LG”等位基因对压力反应以及压力诱导后自愿饮酒的影响。这项研究将促进我们对与战斗有关的创伤事件，压力和饮酒历史之间关系的理解。这一研究线的最终目标是在不健康的饮酒习惯和/或依赖性发展之前，在饮酒职业生涯的早期就确定“处于危险”群体。该信息有可能为预防和干预酒精研究提供信息。