Chemosensory pathways in food intake

食物摄入中的化学感应途径

基本信息

批准号：
8636331
负责人：
TIMOTHY A. GILBERTSON
金额：
$ 21.15万
依托单位：
UTAH STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-06 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8636331
关键词：
1,2-diacylglycerol Animals Binding Blood Body Composition Body Weight Body Weights and Measures Body fat CD36 gene Calcium Carbohydrates Cells Chemicals Cholecystokinin Cholesterol Cues Data Diet Dietary Fats Diglycerides Disease Eating Enteroendocrine Cell Epidemic Event Exercise Exploratory/Developmental Grant Fat Body Fatty Acids Fatty acid glycerol esters Food G-Protein-Coupled Receptors Gallbladder Gender Generations Goals Incidence Indium Inositol Intake Intubation Knock-out Lead Link Liquid substance Liver Macronutrients Nutrition Measures Metric Modeling Mus Neuraxis Nutrient Obesity Outcome Pathway interactions Phospholipase Physiological Processes Play Production Receptor Cell Regulation Research Research Project Grants Role Series Serum Signal Pathway Signal Transduction Site Solid Specificity Stimulus Taste Perception Testing Time Triglycerides Weight Wild Type Mouse Work absorption base bile salts design detection of nutrient dietary control fatty acid-binding proteins feeding follow-up gastrointestinal system interest male novel preference programs public health relevance receptor research study response somatosensory therapy design

项目摘要

The incidence of obesity worldwide continues to escalate with the spread of the Western diet and with it there has been a corresponding increase in numerous obesity-related disorders. Of all the causes for obesity, the predominant one seems to be choice - the choice to eat more and exercise less. One of the choices that has been linked with obesity has been the selection of a high fat, calorically dense diet. Recent research has shown that fatty acids are the prototypical fat stimulus in the gustatory, digestive, somatosensory and central nervous systems. This proposal seeks to follow up on interesting observations that show in mice deletions in important elements in the fatty acid signaling pathway lead to decreases in fat intake and concomitant reductions in body weight and body fat. In this two year exploratory proposal we will attempt to discern (1) the effect specific fatty acid signaling components have on dietary fat intake and body composition; (2) whether pre- or post-ingestive signaling contributes to the control of fat intake and (3) the nutrient specificity of any changes in food intake associated with aberrant fatty acid signaling. Understanding the role of chemosensory signals in the control of nutrient intake is poorly understood and the finding that alterations in a specific chemosensory pathways alters dietary fat intake remains highly novel and potentially important for the control of dietary-induced obesity.

随着西方饮食的传播，全球肥胖的发生率继续升级许多与肥胖相关疾病的相应增加。在肥胖的所有原因中主要的选择似乎是选择 - 选择更多和锻炼的选择。具有的选择之一与肥胖有关的是选择高脂肪，热量致密的饮食。最近的研究已有表明脂肪酸是味道，消化，体感和中央的典型脂肪刺激神经系统。该提案试图跟进显示小鼠删除中删除的有趣观察结果脂肪酸信号通路中的重要元素导致脂肪摄入和随之减少减少体重和体内脂肪。在这两年的探索性建议中，我们将尝试辨别（1）影响特定的脂肪酸信号传导成分对饮食脂肪摄入和身体成分的影响；（2）是否结构前或后信号传导有助于控制脂肪摄入，（3）任何的营养特异性与异常脂肪酸信号传导相关的食物摄入量的变化。了解化学感应的作用控制营养摄入量的信号对特定的变化的理解很少化学感应途径改变了饮食脂肪的摄入量仍然高度新颖，对对照可能很重要饮食引起的肥胖症。