iTC200 MicroCalorimetry Cell Control Unit

iTC200 微量热池控制单元

• 批准号: 8639053
• 负责人: Courtney C Aldrich
• 金额: $ 9.36万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639053
• 关键词: Address; Affinity; Anthrax disease; Area; Biochemistry; Biological Process; Biomedical Research; Biophysics; Cells; Chemistry; Cities; Disease; Dissociation; Drug Targeting; Equipment; Funding; Grant; HIV; Heart failure; Hydrogen Bonding; Institutes; Knowledge; Ligands; Male Contraceptive Agents; Malignant Neoplasms; Minnesota; Molecular Biology; Pharmaceutical Chemistry; Relative (related person); Research; Research Personnel; Therapeutic; Thermodynamics; Titrations; Training; Tuberculosis; Twin Multiple Birth; United States National Institutes of Health; Universities; carcinogenesis; design; drug discovery; enthalpy; inhibitor/antagonist; instrument; microcalorimetry; receptor; small molecule

DESCRIPTION (provided by applicant): This equipment grant is requesting funds for the purchase of an isothermal titration microcalorimeter (ITC) for the determination of ligand receptor dissociation constants and thermodynamic parameters by a group of very productive NIH-funded researchers in chemistry, medicinal chemistry, biochemistry, molecular biology, and biophysics. These investigators are involved in NIH funded research that deals either with the design and synthesis of small molecules for potential drug targets or the utilization of small molecule ligands to study biological processes associated with various diseases. Their research addresses such diverse areas as male contraceptives, tuberculosis, anthrax, heart failure, cancer, carcinogenesis, and HIV. Presently, there is no available ITC instrument at the University of Minnesota-Twin Cities campus, which is a leader nationally in biomedical research. Many inhibitors derive their affinity by non- specific entropic interactions (i.e. desolvation) rater than specific hydrogen-bonding and van der Waal interactions that is manifested in the enthalpy. Thus, knowledge of the relative thermodynamic signature is vitally important. The Institute of Therapeutics and Drug Discovery (ITDD) will maintain the instrument and provide user training of the ITC, which will be paid for by the Department of Medicinal Chemistry.

描述（由申请人提供）：该设备拨款要求购买等温滴定微量敏水仪（ITC），以确定一组非常有生产力的NIH资助的NIH资助的化学，药物化学，生物化学，生物学，分解生物学，和物质生物学，以及一组非常有生产力的NIH资助的NIH资助的NIH资助的研究人员。这些研究者参与了NIH资助的研究，该研究涉及针对潜在药物靶标的小分子的设计和合成，或者使用小分子配体来研究与各种疾病相关的生物学过程。他们的研究涉及诸如男性避孕药，结核病，炭疽，心力衰竭，癌症，致癌和HIV等不同地区。目前，明尼苏达大学两国城市校园没有可用的ITC工具，该校园是全国生物医学研究领域的领导者。许多抑制剂通过非特异性熵相互作用（即脱溶剂）的评估者而获得其亲和力，而不是特定的氢键和范德华相互作用。因此，对相对热力学特征的了解至关重要。治疗和药物发现研究所（ITDD）将维护该工具并提供ITC的用户培训，该ITC将由药物化学系支付。

项目成果

Multiplex surface-enhanced Raman scattering detection of deoxynivalenol and ochratoxin A with a linear polymer affinity agent.

• DOI: 10.1039/d0ma00608d
• 发表时间: 2020-12-01
• 期刊: Materials advances
• 影响因子: 5
• 作者: Rodriguez RS;Szlag VM;Reineke TM;Haynes CL
• 通讯作者: Haynes CL