Environmental Change and Inflammation: Age, Cohort and Household Effects in China

环境变化和炎症：中国的年龄、群体和家庭影响

• 批准号: 8637666
• 负责人: Amanda L Thompson
• 金额: $ 11.32万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-22 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8637666
• 关键词: Abdomen; Accounting; Acute-Phase Proteins; Address; Adolescence; Adolescent and Young Adult; Adult; Age; Anthropometry; Award; Behavioral; Biological; Biological Markers; Biological Models; C-reactive protein; Characteristics; Child; Childhood; China; Chronic; Chronic Disease; Cohort Analysis; Cohort Effect; Communities; Complex; Data; Data Set; Demography; Development; Diet; Disease; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Methods; Exposure to; Fatty acid glycerol esters; Fostering; Funding; Generations; Health; Health Surveys; Heterogeneity; Hormonal; Household; Human; Human Biology; Immunology; Individual; Inflammation; K-Series Research Career Programs; Laboratories; Life Cycle Stages; Life Style; Linear Models; Link; Longitudinal Studies; Measures; Mentors; Mentorship; Methods; Modeling; Modernization; Nutrition Surveys; Nutritional; Obesity; Outcome; Pathway interactions; Pattern; Physical activity; Physical environment; Population; Positioning Attribute; Prevalence; Recording of previous events; Research; Research Training; Rural; Sanitation; Scientist; Shapes; Social Environment; Socioeconomic Status; Testing; Training; United States; United States National Institutes of Health; Universities; Urbanization; Work; age group; age related; base; burden of illness; cohort; driving force; early life exposure; environmental change; experience; immune activation; improved; innovation; nutrition; pathogen exposure; public health relevance; residence; skills; social; successful intervention; tool; waist circumference; young adult

DESCRIPTION (provided by applicant): Early life exposure to changing social and physical environments has been implicated as a driving force in the increasing global prevalence of obesity and chronic disease at younger ages. However, understanding of the complex pathways linking environmental exposures to the development of health and disease across the life course has been limited by methodological difficulties in disentangling the effects of changing environments from individual, age-related vulnerability to environmental change. The proposed career development award addresses this gap, bringing together training in sophisticated demographic methods and a unique dataset, the China Health and Nutrition Study, a 20-year NIH study of >11,000 individuals in 4400 households capturing dramatic changes in diet, disease burden and lifestyles, to characterize environmental determinants of inflammation, a measure of chronic immune activation linked to the development of cardiometabolic disease. Drawing on a life course framework, this project examines the pathways linking social and physical environments to inflammation among children, adolescents and young adults through three specific aims: 1) the characterization of salient social, behavioral, biological and physical environmental predictors of inflammation across age groups and urban/rural residence, 2) the use of latent class trajectory models and age, period, cohort analysis to characterize longitudinal patterns of exposure to pathogenic and obesogenic environments, and 3) the identification of shared and unique predictors of inflammation within individual households to address age and cohort differences in vulnerability on the micro-environmental level. This award will incorporate formal training in demography, mentorship from leaders in the fields of demography and nutrition, and fieldwork in China to create innovative models more broadly applicable to questions of health in changing environments in China and globally. The institutional environments, the Carolina Population Center, UNC- Chapel Hill and Duke University, and mentoring by an inter-disciplinary team of experts, will foster the development of a new research niche linking a human biological focus on the development of chronic disease with sophisticated demographic analytic tools. This training and mentoring will provide the unique set of skills I need to make a large step forward from my background in narrower bench research and smaller-scale human biology work to become an independent population scientist with a dynamic perspective on the interplay of environment and inflammation and a capacity to make significant, interdisciplinary contributions to the study of human health and disease.

描述（由申请人提供）：早期生命暴露于不断变化的社会和身体环境中，这被牵涉到年轻时肥胖症和慢性病的全球流行率增加的驱动力。然而，了解将环境暴露与整个生活过程中的健康和疾病发展联系起来的复杂途径受到方法论上的困难的限制，从而使环境从个人，与年龄相关的脆弱性转变为环境变化的影响。 The proposed career development award addresses this gap, bringing together training in sophisticated demographic methods and a unique dataset, the China Health and Nutrition Study, a 20-year NIH study of >11,000 individuals in 4400 households capturing dramatic changes in diet, disease burden and lifestyles, to characterize environmental determinants of inflammation, a measure of chronic immune activation linked to the development of cardiometabolic disease.该项目借鉴了生活课程框架，研究了将社会和身体环境与儿童，青少年和年轻人之间的炎症联系起来的途径：1）显着的社会，行为，生物学，生物学和身体的表征 跨年龄段和城市/农村住宅的炎症的环境预测指标，2）使用潜在的类轨迹模型和年龄，时期，同类分析来表征纵向 暴露于致病和肥胖环境的模式，以及3）鉴定单个家庭内炎症的共享和独特的预测因素，以解决微环境水平上脆弱性的年龄和队列差异。该奖项将纳入人口统计学和营养领域领导者的指导以及中国实地调查的正式培训，以创建更广泛地适用于中国和全球环境中健康问题的创新模式。机构环境，卡罗来纳州人口中心，UNC教堂山和杜克大学，并由跨学科的专家团队指导，将促进一项新的研究的发展，将人类生物学关注慢性疾病的发展与精致的人口统计学分析工具联系起来。这项培训和指导将提供一套独特的技能，我需要从狭窄的台式研究和较小规模的人类生物学工作中迈出巨大的一步，以成为一名独立的人群科学家，对环境和炎症的相互作用具有动态观点，并具有对人类健康和疾病研究的重要，跨学科的能力。