Genetic and Psychosocial Predictors of Blood Pressure and Body Mass Index

血压和体重指数的遗传和社会心理预测因素

• 批准号: 8738570
• 负责人: Sharon L Kardia
• 金额: $ 14万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738570
• 关键词: Adult; African American; Age; Biological; Blood Pressure; Body mass index; Chromosomes; Chronic Disease; Cohort Studies; Complex; Consensus; Data; Dietary intake; Disadvantaged; Documentation; Economics; Elderly; Environment; Ethnic Origin; Ethnic group; Etiology; Genes; Genetic; Genomics; Health; Health behavior; Heritability; Hispanics; Hypertension; Income; Individual; Lead; Life; Link; Measures; Mediating; Methods; Molecular; Neighborhoods; Neurosecretory Systems; Not Hispanic or Latino; Obesity; Outcome; Pathway interactions; Personal Satisfaction; Phenotype; Physical activity; Plant Roots; Population; Psychosocial Factor; Race; Research; Respondent; Retirement; Risk Factors; Role; Sample Size; Sampling; Single Nucleotide Polymorphism; Social Characteristics; Socioeconomic Status; Stress; Surveys; Variant; Work; base; cohort; database of Genotypes and Phenotypes; disability; falls; gene environment interaction; genome-wide; health disparity; low socioeconomic status; novel; physical conditioning; psychosocial; racial and ethnic disparities; social; socioeconomics; trait; Adult; African American; Age; Biological; Blood Pressure; Body mass index; Chromosomes; Chronic Disease; Cohort Studies; Complex; Consensus; Data; Dietary intake; Disadvantaged; Documentation; Economics; Elderly; Environment; Ethnic Origin; Ethnic group; Etiology; Genes; Genetic; Genomics; Health; Health behavior; Heritability; Hispanics; Hypertension; Income; Individual; Lead; Life; Link; Measures; Mediating; Methods; Molecular; Neighborhoods; Neurosecretory Systems; Not Hispanic or Latino; Obesity; Outcome; Pathway interactions; Personal Satisfaction; Phenotype; Physical activity; Plant Roots; Population; Psychosocial Factor; Race; Research; Respondent; Retirement; Risk Factors; Role; Sample Size; Sampling; Single Nucleotide Polymorphism; Social Characteristics; Socioeconomic Status; Stress; Surveys; Variant; Work; base; cohort; database of Genotypes and Phenotypes; disability; falls; gene environment interaction; genome-wide; health disparity; low socioeconomic status; novel; physical conditioning; psychosocial; racial and ethnic disparities; social; socioeconomics; trait

DESCRIPTION (provided by applicant): There is an emerging consensus that individual health outcomes are a result of multiple factors that range from biological to societal and that the proper understanding and quantification of the etiologic roles of genes and environments in the causation of diseases will require consideration of gene by environment interactions. However, traditional approaches to understanding the causes of individual health outcomes remain fragmented into "biological" and "social" approaches. Just as this paradigm often falls short in adequately explaining the causes for individual health outcomes, it also fails to adequately explain disparities in health outcomes at the population level. Despite the repeated documentation of racial and ethnic disparities in hypertension and obesity there is still substantial debate about their root causes. Identifying the range of factors that lead to the persistent and pronounced differences in the blood pressures and/or body mass index (BMI) of populations is critical for developing effective strategies for reducing these disparities. The Health Retirement Study (HRS) is a key cohort in which to conduct research at the intersection of the biological and social since it is a nationally- representative longitudinal panel study of oer 26,000 adults over age 50 (surveyed every two years). The rich combination of the blood pressure and BMI measures along with genomic data in the HRS presents an important opportunity to investigate the contribution of genetic, socioeconomic, and psychosocial factors to blood pressure and BMI in a large cohort study to accomplish the following specific aims: Aim 1: Estimate molecular-based heritability of blood pressure and body mass index (BMI) in a multi-ethnic cohort of nearly 16,000 older adults from the Health and Retirement Study. Aim 2: Investigate the gene-level and SNP-level associations of 60 gene regions that have significant and replicated evidence of association with blood pressure and BMI. Aim 3: Investigate socioeconomic status and psychosocial factors as modifiers of the molecular-based heritability, gene-level associations, and SNP-level associations with blood pressure and BMI.

描述（由申请人提供）：有一个新的共识，即个人健康结果是从生物学到社会范围的多种因素的结果，并且正确理解和量化基因和环境在疾病的病因中的病因学作用将需要通过环境相互作用来考虑基因的基因。但是，了解个人健康结果原因的传统方法仍然分散为“生物学”和“社会”方法。正如这种范式在充分解释个人健康成果的原因方面常常缺乏一样，它也无法充分解释人口水平的健康结果差异。尽管在高血压和肥胖症中反复记录了种族和种族差异，但关于其根本原因仍然存在重大辩论。确定导致人群血压和/或体重指数（BMI）持续且明显差异的因素范围对于制定有效降低这些差异的有效策略至关重要。健康退休研究（HRS）是在生物学和社会交集中进行研究的关键队列，因为它是全国代表性的纵向纵向小组研究，对50岁以上的26,000名成年人（每两年进行一次调查）。 The rich combination of the blood pressure and BMI measures along with genomic data in the HRS presents an important opportunity to investigate the contribution of genetic, socioeconomic, and psychosocial factors to blood pressure and BMI in a large cohort study to accomplish the following specific aims: Aim 1: Estimate molecular-based heritability of blood pressure and body mass index (BMI) in a multi-ethnic cohort of nearly 16,000 older adults from the Health和退休研究。目标2：研究60个基因区域的基因级和SNP级关联，这些基因区域具有显着且复制的与血压和BMI相关的证据。 AIM 3：研究社会经济状况和社会心理因素，作为基于分子的遗传力，基因级关联以及SNP级关联与血压和BMI的修饰。