Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation

偏心运动引起的肌肉无力和炎症的按摩疗法

基本信息

批准号：
8290073
负责人：
Thomas Michael Best
金额：
$ 38.69万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8290073
关键词：
Actins Acupuncture procedure Acute Affect American Animal Model Anti-Inflammatory Agents Anti-inflammatory Articular Range of Motion Athletic Basic Science Biological Biological Markers Biomechanics Bradykinin Calcitonin Gene-Related Peptide Cell Differentiation process Cell Proliferation Cells Chronic Clinical Clinical Trials Clinical effectiveness Collagen Data Devices Dinoprostone Economic Burden Edema Effectiveness Enzymes Exercise Frequencies Functional disorder Future Gene Expression Genes Healed Health Human In Vitro Infiltration Inflammation Inflammatory Injury Insulin-Like Growth Factor I Interleukins Isometric Exercise Joints Leukocytes Ligaments Liver M-cadherin Massage Measures Mediator of activation protein Medical Membrane Modeling Molecular Muscle Muscle Cells Muscle Fibers Muscle Proteins Muscle Tension Muscle Weakness Muscle function Muscle strain Musculoskeletal Myalgia Myogenin Myosin Heavy Chains Oryctolagus cuniculus Pain Pathway interactions Patients Performance Pharmaceutical Preparations Pharmacologic Substance Phase Physicians Pilot Projects Process Proteolysis RNA Splicing Recovery Regimen Regulation Relative (related person)Research Signal Transduction Simulate Skeletal Muscle Somatomedins Spasm Sprain Staging Structural Protein Structure Substance P Swelling TNF gene Technology Testing Time Tissues Torque Tube Tumor Necrosis Factor-alpha Ubiquitin United States Variant Visit Weight Work Yoga analytical method base cyclooxygenase 2 cytokine design gene induction healing human NOS2A protein immunopathology improved in vivo inflammatory pain innovation joint function mRNA Expression macrophage meetings multicatalytic endopeptidase complex multidisciplinary muscle form muscle regeneration neutrophil novel protein degradation regenerative repaired research study response success

项目摘要

DESCRIPTION (provided by applicant): Acute and chronic skeletal muscle pain and weakness are among the most common ailments in a general medical practice. While treating muscle weakness and pain with pharmaceutical drugs and traditional exercise regimens has met with some success, large numbers of people have turned to alternative approaches including myofacial release, massage, acupuncture, and yoga. According to the American Massage Therapy Association (AMTA, http://www.amtamassage.org) the benefits of massage on muscle include; relief of muscle tension and stiffness, faster healing of strained muscles and sprained ligaments, reduced muscle pain, swelling, and spasm, greater range of motion, and even enhanced athletic performance. Although at this time many claims are made about massage, there are only a few studies to support its use. Moreover, the biological mechanism(s) by which massage works are largely unknown. To this end, we have employed our well-established in vivo rabbit model of eccentric exercise- induced muscle inflammation and weakness that closely mimics muscle injuries in athletes to examine the efficacy of massage therapies. Pilot studies have shown that four sessions of daily massage (using a self-designed and fabricated device capable of producing repeatable loading) can improve recovery of muscle function up to 120% over than the control while at the same time reducing tissue inflammation. Our overall hypothesis is that biomechanical signals generated during massage therapies at the correct magnitude, duration, and frequency are, (i) potent anti- inflammatory signals that inhibit muscle inflammation by suppressing expression of proinflammatory mediators, and (ii) effective signals that augment muscle regeneration and repair by upregulating expression of genes essential for muscle cell proliferation and differentiation. Three aims will be investigated utilizing state of the art technologies and analytical methods to determine an optimal magnitude, duration, and frequency of massage to restore muscle function (peak isometric torque) while investigating the effects of this combination on the host inflammatory and regenerative and reparative responses. This multidisciplinary effort will hopefully provide a strong rationale for future mechanistic studies and eventually clinical trials investigating the optimal indications and strategies for massage therapies to restore skeletal muscle dysfunction and improve overall human health. PUBLIC HEALTH RELEVANCE: Although the effectiveness of massage for overcoming muscle weakness following exercise is limited to a few high quality studies, Americans make more than 160 million visits annually to seek relief of musculoskeletal weakness and pain by manipulative or body-based practices. This basic science research is aimed at understanding the mechanisms of action of massage therapies to understand the basis of their effectiveness and to develop innovative strategies to maximize their clinical effectiveness.

描述（由申请人提供）：急性和慢性骨骼肌疼痛和无力是一般医疗实践中最常见的疾病。虽然用药物和传统运动疗法治疗肌肉无力和疼痛已经取得了一些成功，但很多人已经转向其他方法，包括肌筋膜放松、按摩、针灸和瑜伽。根据美国按摩治疗协会（AMTA，http://www.amtamassage.org）的说法，按摩对肌肉的好处包括：缓解肌肉紧张和僵硬，更快地愈合拉伤的肌肉和扭伤的韧带，减少肌肉疼痛、肿胀和痉挛，更大的运动范围，甚至增强运动表现。尽管目前有许多关于按摩的说法，但只有少数研究支持其用途。此外，按摩起作用的生物机制在很大程度上是未知的。为此，我们采用了完善的离心运动引起的肌肉炎症和无力体内兔子模型，该模型非常模拟运动员的肌肉损伤，以检查按摩疗法的功效。试点研究表明，每日四次按摩（使用自行设计和制造的能够产生可重复负荷的装置）可以使肌肉功能恢复比对照提高高达 120%，同时减少组织炎症。我们的总体假设是，按摩治疗期间以正确的强度、持续时间和频率产生的生物力学信号是：（i）通过抑制促炎介质的表达来抑制肌肉炎症的有效抗炎信号，以及（ii）增强肌肉的有效信号通过上调肌肉细胞增殖和分化所必需的基因表达来实现再生和修复。将利用最先进的技术和分析方法来研究三个目标，以确定恢复肌肉功能（峰值等长扭矩）的最佳按摩幅度、持续时间和频率，同时研究这种组合对宿主炎症、再生和修复的影响回应。这项多学科的努力有望为未来的机制研究和最终的临床试验提供强有力的理论依据，以调查按摩疗法的最佳适应症和策略，以恢复骨骼肌功能障碍并改善人类整体健康。公共健康相关性：尽管按摩对于克服运动后肌肉无力的有效性仅限于一些高质量的研究，但美国人每年有超过 1.6 亿人次前来寻求通过手法或身体练习来缓解肌肉骨骼无力和疼痛。这项基础科学研究旨在了解按摩疗法的作用机制，了解其有效性的基础，并制定创新策略以最大限度地提高其临床有效性。