Phenotypic characterization of itm2a-deficiency in T cells

T 细胞 itm2a 缺陷的表型特征

• 批准号: 8227163
• 负责人: I-CHENG HO
• 金额: $ 8.69万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8227163
• 关键词: Affect; Antibodies; Autoimmune Diseases; Bacteria; Biological Markers; Biology; Cell Differentiation process; Cells; Clinical; Data; Development; Disease; Gene Targeting; Goals; Immune; Integral Membrane Protein; Invaded; Laboratories; Lead; Leukocytes; Lupus; Mediating; Molecular; Mouse Strains; Multiple Sclerosis; Mus; Organ; Pathway interactions; Peripheral; Phenotype; Physiological; Play; Process; Proteins; Psoriasis; Publishing; Reagent; Rheumatoid Arthritis; Role; Surface; T-Lymphocyte; Th2 Cells; Therapeutic; Thymocyte Development; Virus; crosslink; neoplastic cell; novel; pathogen; therapeutic target; thymocyte; transcription factor

DESCRIPTION (provided by applicant): T lymphocytes (T cells) are a subset of white blood cells and are essential for eradicating invading bacteria, virus, and tumor cells. However, T cells can also initiate and propagate many autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, and lupus, if their function is not regulated properly. Better understanding of how the development and function of T cells is regulated can lead to novel treatments for many diseases. Preliminary data gathered at Dr. Ho's laboratory has suggested that a novel protein, namely itm2a, plays a critical role in regulating the development and function of T cells. In this project, Dr. Ho's team plans to study the impact of itm2a deficiency on T cells. Results generated from this project will establish itm2a as a rich therapeutic target in many clinical settings. PUBLIC HEALTH RELEVANCE: Targeting T cells is therapeutic in many clinical settings. The molecular mechanism regulating the development and function of T cells is a very complicate process and still not fully understood. Published and our preliminary data have strongly suggested that the integral membrane protein itm2a plays a critical role in regulating the development and function of T cells. However, the physiological function of itm2a is largely unknown. The immediate goal of this project is to characterize the phenotype of T cells and mice that are made deficient in itm2a. Data generated from this project may uncover a novel pathway regulating the development and function of T cells.

描述（由申请人提供）：T淋巴细胞（T细胞）是白细胞的一个子集，对于根除入侵的细菌、病毒和肿瘤细胞至关重要。然而，如果 T 细胞的功能调节不当，它们也会引发和传播许多自身免疫性疾病，例如类风湿性关节炎、多发性硬化症、牛皮癣和狼疮。更好地了解 T 细胞的发育和功能如何调节可以为许多疾病带来新的治疗方法。 Ho 博士实验室收集的初步数据表明，一种新的蛋白质，即 itm2a，在调节 T 细胞的发育和功能中发挥着关键作用。在这个项目中，Ho博士的团队计划研究itm2a缺陷对T细胞的影响。该项目产生的结果将确立 itm2a 作为许多临床环境中丰富的治疗靶点。 公共卫生相关性：靶向 T 细胞在许多临床环境中具有治疗作用。调节T细胞发育和功能的分子机制是一个非常复杂的过程，目前尚未完全了解。已发表的数据和我们的初步数据强烈表明整合膜蛋白 itm2a 在调节 T 细胞的发育和功能中发挥着关键作用。然而，itm2a 的生理功能很大程度上未知。该项目的直接目标是表征缺乏 itm2a 的 T 细胞和小鼠的表型。该项目产生的数据可能会揭示调节 T 细胞发育和功能的新途径。