2012 Biology of Acute Respiratory Infection Gordon Research Conference

2012年急性呼吸道感染生物学戈登研究会议

基本信息

批准号：
8249190
负责人：
Alice S Prince
金额：
$ 0.6万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-15 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8249190
关键词：
2 year old AIDS/HIV problem Acute Acute respiratory infection Address Area Bacteria Bacterial Pneumonia Biology Cessation of life Child Collaborations Communities Data Disabled Persons Epidemiology Epithelial Europe Fostering Funding Goals Healthcare Hospitalization Host Defense Human Immune Immune response Immunologics Immunologist Immunology Infection Influenza Lead Lipoxins Lung Malignant Neoplasms Medical Modeling Morbidity - disease rate Mucosal Immune Responses Mycoplasma pneumoniae Natural Immunity Organism Pathogenesis Pathology Pertussis Pneumococcal vaccine Pneumonia Postdoctoral Fellow Prevention Prevention strategy Public Health Reagent Request for Applications Research Research Personnel Respiratory Tract Infections Role Running Scientist Signal Transduction Staging Staphylococcus aureus Streptococcus pneumoniae Technology Thinking Time Underrepresented Minority Viral Pathogenesis Virus Virus Diseases Woman Work adaptive immunity career cost disorder prevention experience fungus graduate student influenza virus vaccine interest meetings methicillin resistant Staphylococcus aureus microbial mortality novel strategies pathogen peer posters response symposium vaccine development

项目摘要

DESCRIPTION: This application requests funding to partially support the third meeting of the Gordon Research Conference on the Biology of Acute Respiratory Infection. This meeting will be held in Ventura, CA March 11-16, 2012 and we expect 110 - 150 scientists to participate. The overarching goal of this multi-disciplinary conference is to provide a setting to present and discuss outstanding research in the area of acute lung infection. As the diverse pathogens that infect the lung activate a limited number of conserved immunologic responses, there is a great deal of information that can be shared by colleagues working in and by colleagues who study different pathogens. General principles of vaccine development, particularly the activation of local immune protection are highly relevant to many different types of pulmonary infection. The meeting will run for 4 1/2 days leading off with presentations each morning dealing with general topics in innate immunity relevant to diverse types of lung infection. Sessions devoted to specific pathogens will be held in morning and evening sessions, each led by an experienced discussion leader, often a scientist who has presented their own work at previous meetings. Topics will include major causes of bacterial pneumonia, Streptococcus pneumoniae, Staphylococcus aureus (especially MRSA) Mycoplasma pneumoniae and pertussis. Sessions focusing upon viral pathogenesis and prevention will be held focusing on influenza, RSV and mixed bacterial/viral infection. Several talks will address the host response to infection; the participation of lipoxins and resolvins, the role of epithelial signaling in host defense, and the recruitment of PMNs to the lung will be included. Afternoon poster sessions will provide an informal venue to discuss work-in progress and enable graduate students and post-docs to meet with various luminaries in their field of interest as well as their peers. At all stages of speaker invitation and recruitment of attendees we have made every effort to encourage participation by women, underrepresented minorities and people with disabilities. As pulmonary infection is a leading cause of mortality in the USA and worldwide this conference is highly relevant to public health and will potentially foster novel approaches to disease prevention and vaccine development. PUBLIC HEALTH RELEVANCE: Acute lung infections are a major cause of morbidity and mortality, associated with a greater number of deaths each year in the USA than HIV/AIDS and cancer combined. The health care associated costs of community-acquired pneumonia in 2007 exceeded 2 billion dollars/year in Europe alone, despite the availability of pneumococcal and influenza vaccines. The cost of RSV hospitalizations for children under 2 years of age in the US exceeds 384 million dollars per year. Although many different types of pathogens infect the lung, there are conserved mucosal immune responses to these infections. The purpose of this conference is to provide a forum for investigators who study acute lung infections to better understand microbial pathogenesis and the intricacies of the immune responses evoked which cause much pathology. This Gordon research Conference will provide an opportunity to share new hypotheses, discuss novel approaches and establish collaborations to better understand the pathogenesis of lung infection and hopefully develop better strategies for prevention and treatment.

描述：本申请请求资金部分支持戈登急性呼吸道感染生物学研究会议第三次会议。本次会议将于 2012 年 3 月 11 日至 16 日在加利福尼亚州文图拉举行，我们预计将有 110 至 150 名科学家参加。这次多学科会议的总体目标是提供一个展示和讨论急性肺部感染领域的杰出研究的环境。由于感染肺部的多种病原体会激活有限数量的保守免疫反应，因此工作于不同病原体的同事以及研究不同病原体的同事可以共享大量信息。疫苗开发的一般原则，特别是局部免疫保护的激活与许多不同类型的肺部感染高度相关。会议将持续 4 1/2 天，每天早上都会进行演讲，讨论与不同类型肺部感染相关的先天免疫的一般主题。专门讨论具体问题的会议病原体将在早间和晚间举行，每次会议均由一位经验丰富的讨论领导者主持，通常是一位在之前的会议上介绍过自己工作的科学家。主题将包括细菌性肺炎、肺炎链球菌、金黄色葡萄球菌（特别是耐甲氧西林金黄色葡萄球菌）、肺炎支原体和百日咳的主要原因。会议将重点关注病毒发病机制和预防，重点关注流感、RSV 和混合细菌/病毒感染。一些演讲将讨论宿主对感染的反应；脂氧素和溶解素的参与、上皮信号传导在宿主防御中的作用以及中性粒细胞向肺部的募集也将包括在内。下午的海报会议将提供一个非正式的场所来讨论正在进行的工作，并使研究生和博士后能够与他们感兴趣的领域的各种杰出人物以及同行会面。在演讲者邀请和与会者招募的各个阶段，我们都尽一切努力鼓励妇女、代表性不足的少数群体和残疾人的参与。由于肺部感染是美国和世界各地死亡的主要原因，本次会议与公共卫生高度相关，并将有可能促进疾病预防和疫苗开发的新方法。公共卫生相关性：急性肺部感染是发病和死亡的主要原因，在美国每年造成的死亡人数比艾滋病毒/艾滋病和癌症死亡人数的总和还多。尽管有肺炎球菌疫苗和流感疫苗，2007 年仅在欧洲，社区获得性肺炎造成的医疗保健相关费用就超过了 20 亿美元/年。美国 2 岁以下儿童每年因 RSV 住院的费用超过 3.84 亿美元。尽管许多不同类型的病原体感染肺部，但对这些感染有保守的粘膜免疫反应。本次会议的目的是为研究急性肺部感染的研究人员提供一个论坛，以更好地了解微生物发病机制以及引起多种病理学的免疫反应的复杂性。这次戈登研究会议将提供一个分享新假设、讨论新方法和建立合作的机会，以更好地了解肺部感染的发病机制，并有望制定更好的预防和治疗策略。