Deer Mice as Tools for Infectious Disease Research

鹿鼠作为传染病研究的工具

基本信息

批准号：
8496418
负责人：
Ann Hawkinson
金额：
$ 39.39万
依托单位：
UNIVERSITY OF NORTHERN COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8496418
关键词：
Accounting Address American Andes Virus Anti-Inflammatory Agents Anti-inflammatory Antibodies Antiviral Agents Biochemical Biochemistry Cardiopulmonary Cell Culture Techniques Cells Data Deer Mouse Disease Ecology Embryo Event Exhibits Fibroblasts Funding Gene Expression Genes Genetic Hantavirus Hantavirus Infections Human Immune Immune response Infection Infectious Diseases Research Inflammatory Interferon Type I Interferons Interleukin-4 Kinetics Laboratories Lead Learning Life Lymph Node Tissue Mediating Molecular Genetics Molecular Profiling North America Outcome Pathology Pathway interactions Pattern Peromyscus Phosphorylation Positioning Attribute Preparation Principal Investigator Proteins RNA Rattus norvegicus Regulatory T-Lymphocyte Rice Rats Rodent Role Seoul virus Signal Pathway Sin Nombre virus South America Students Symptoms Syndrome T cell response T-Lymphocyte Tail Therapeutic Intervention Time Viral Virus Virus Diseases cytokine gene repression human disease programs public health relevance response tool vaccine development

项目摘要

DESCRIPTION (provided by applicant): Deer mice are the principal reservoir hosts of Sin Nombre virus, which causes the great majority of hantavirus cardiopulmonary syndrome cases in North America. Unlike human infections, which are fatal in about a third of the cases, infected deer mice do no exhibit symptoms of disease and remain otherwise healthy but persistently infected, probably for life. This project has focused on understanding the immunological events that lead to persistent infection without disease. Our efforts have demonstrated that an anti-inflammatory immune response appears to predominate at persistence and this response likely limits pathology, but also compromises viral clearance. Andes virus also infects deer mice; however, it is cleared without disease. The project will continue to examine how SNV evades the host response and why Andes virus is cleared by focusing on the genetic, molecular and cellular events during the host response to these viruses.

描述（由申请人提供）：鹿小鼠是Sin nombre病毒的主要储层，它导致北美大部分hantavirus心肺综合症病例。与人类感染在大约三分之一的病例中是致命的，被感染的鹿小鼠没有表现出疾病的症状，否则健康但持续感染，可能是生命的。该项目的重点是理解导致持续感染而没有疾病的免疫事件。我们的努力表明，抗炎免疫反应似乎在持久性时占主导地位，这种反应可能限制了病理，但也损害了病毒清除率。安第斯山脉病毒还感染了鹿小鼠。但是，它被清除而没有疾病。该项目将继续研究SNV如何通过关注对这些病毒的宿主反应期间的遗传，分子和细胞事件来清除Andes病毒的原因。