GH12-004, S. Africa: GDD Public Health Research

GH12-004，南非：GDD 公共卫生研究

• 批准号: 8728799
• 负责人: Natalie Mayet
• 金额: $ 174.99万
• 依托单位: NATIONAL HEALTH LABORATORY SERVICE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8728799
• 关键词: GH12; 004; S.; Africa; GDD

DESCRIPTION (provided by the applicant - verbatim): Malaria vector control relies principally on the application of chemical insecticides. However, the current drive towards sequential elimination and eradication of malaria in South Africa requires that additional control tools be developed to complement existing strategies. The aim of this project is to evaluate three unrelated malaria vector control technologies within South Africa. The principal objectives are to: 1. Establish the feasibility of the sterile insect technique for malaria vector control in South Africa. The specific aim of this objective is to ascertain the relative mating competitiveness of sterile laboratory reared male Anopheles arabiensis mosquitoes compared to their fertile wild counterparts as well as to measure the Plasmodium infectivity of irradiated females compared to unirradiated females. 2. Test white pepper and piperine, a key constituent of pepper, as malaria vector larvicides in South Africa. 3. Test the repellent and insecticidal properties of C8910 against insecticide resistant and susceptible strains of malaria vector species. .

描述（由申请人逐字提供）： 疟疾媒介控制主要依靠化学杀虫剂的应用。然而，目前南非逐步消除和根除疟疾的努力需要开发额外的控制工具来补充现有战略。 该项目的目的是评估南非境内三种不相关的疟疾病媒控制技术。主要目标是： 1. 确定昆虫不育技术在南非控制疟疾病媒的可行性。该目标的具体目的是确定实验室饲养的不育雄性阿拉伯按蚊与可繁殖的野生按蚊相比的相对交配竞争力，以及测量受辐射雌性与未受辐射雌性相比的疟原虫感染性。 2. 在南方测试白胡椒和胡椒碱（胡椒的主要成分）作为疟疾媒介幼虫剂 非洲。 3. 测试C8910对疟疾病媒物种的抗药性和敏感菌株的驱避和杀虫特性。 。