Metabolic and Energetic Consequences of Fatherhood

父亲身份对新陈代谢和精力的影响

• 批准号: 8430322
• 负责人: Mark A Chappell
• 金额: $ 19.84万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8430322
• 关键词: Acute; Address; Adverse effects; Affect; Age; Androgens; Animals; Behavior; Biological; Biological Markers; Biological Models; Biology; Blood; Blood Glucose; Body Composition; Body fat; California; Caring; Child; Cholesterol; Chronic; Chronic stress; Corticosterone; Cross-Sectional Studies; Data; Development; Diet; Eating; Endocrine; Energy Metabolism; Exposure to; Fasting; Fathers; Fatty acid glycerol esters; Feeding behaviors; Female; Foundations; Future; Glucocorticoids; Glucose; Health; Homeostasis; Hormonal; Hormones; Housing; Human; Laboratories; Lead; Leptin; Link; Longevity; Longitudinal Studies; Mammals; Measures; Mediating; Mental Health; Metabolic; Metabolism; Morbidity - disease rate; Mus; Noise; Organ; Outcome; Pair Bond; Parents; Partner in relationship; Paternal Age; Peromyscus; Physiological; Plasma; Postpartum Period; Process; Prolactin; Psychosocial Stress; Regulation; Research; Rest; Rodent; Solutions; Stress; Sucrose; Testing; Testosterone; Thyroid Hormones; Thyroxine; Time; Triglycerides; Triiodothyronine; Woman; adiponectin; disorder risk; experience; fatherhood; improved; insight; longitudinal design; male; male health; men; mortality; motherhood; offspring; parity; physical conditioning; preference; protective effect; public health relevance; pup; reproductive; research study; stressor

DESCRIPTION (provided by applicant): Fatherhood can influence health and longevity in men. The mechanisms underlying these effects are unknown; however, as human and other mammalian fathers undergo predictable changes in several metabolically important hormones, one possibility is that these endocrine profiles influence energy homeostasis, metabolism, and body composition, which in turn can affect health and longevity. The proposed studies will characterize the effects of fatherhood in the California mouse (Peromyscus californicus), a monogamous rodent in which fathers invest extensively in their offspring and undergo systematic changes in hormone levels and body mass. Specifically, this research will test the hypotheses that fatherhood alters: plasma levels of metabolically important hormones (Aim 1); energy homeostasis, metabolism, body mass, and body fat (Aim 2); behaviors that may contribute to these energetic and metabolic effects (Aim 3); and that these consequences of fatherhood are modulated by paternal parity/age, offspring age, and stress. Experiment 1 will use a longitudinal design to characterize the effects of fatherhood on physical (body mass, body composition), energetic (resting and maximal metabolic rates, daily energy expenditure), hormonal (corticosterone, testosterone), and behavioral (ingestive behavior, activity levels) measures. Data will be collected at five time points, spanning approximately a 9-month period, from fathers (housed with a mate and pups) and nonbreeding males (housed with an ovariectomized female). Half of the mice in each group will be exposed to a chronic, intermittent noise stressor, and the other half will be maintained under standard laboratory conditions. Experiment 2 will use a cross-sectional approach to further characterize possible hormonal, metabolic, and behavioral mechanisms underlying the anticipated effects of fatherhood on body mass, body composition, and energetics. Specifically, it will characterize 1) circulating levels of the metabolic hormones leptin, adiponectin, triiodothyronine, and thyroxine; 2) blood triglyceride, cholesterol, and glucose levels; 3) the propensity to ingest high-fat and high-sucrose substances; and 4) organ masses and distribution of fat stores, in nonbreeding males, new fathers, and experienced fathers. Depending on the results of Experiment 1, half of the mice in each group may again be exposed to a chronic, intermittent noise stressor. These studies are expected to demonstrate that fatherhood in P. californicus alters metabolic hormone levels, energy homeostasis, metabolism, body composition, and behavior. They will also clarify how these effects are modulated by paternal age/parity, offspring age, and chronic stress. The results will provide unique insights into the biology of mammalian fatherhood and may eventually lead to an improved understanding of the effects of fatherhood on health and longevity in men, as well as health outcomes in their offspring.

描述（由申请人提供）：父亲身份可以影响男性的健康和寿命。这些作用的基础机制尚不清楚。但是，由于人类和其他哺乳动物的父亲在几种代谢上重要的激素中经历了可预测的变化，因此，这些内分泌特征会影响能量稳态，代谢和身体成分，这又会影响健康和寿命。拟议的研究将表征父亲身份对加利福尼亚小鼠（Peromyscus californicus）的影响，这是一夫一妻制的啮齿动物，其中父亲在其后代进行了大量投资，并经历了激素水平和体重的系统变化。具体而言，这项研究将检验父亲身份改变的假设：代谢重要的激素的等离子体水平（AIM 1）；能量稳态，代谢，体重和体内脂肪（目标2）；可能导致这些能量和代谢作用的行为（AIM 3）；父亲的这些后果是由父亲平价/年龄，后代年龄和压力来调节的。实验1将使用纵向设计来表征父亲身份对身体（体重，身体成分），能量（静息和最大代谢率，每日能量消耗），激素（皮质酮，睾丸激素）和行为（摄入性行为，行为，活动水平）测量水平的影响。数据将在五个时间点收集，大约从父亲（带有伴侣和幼崽）和非繁殖男性（带有卵巢切除型女性的雌性）的五个月（约9个月）收集。每组中一半的小鼠将暴露于慢性间歇性噪声压力源，另一半将在标准实验室条件下保持。实验2将使用横截面方法进一步表征父亲身份对体重，身体组成和能量学的预期影响的荷尔蒙，代谢和行为机制。具体而言，它将表征1） 代谢激素瘦素，脂联素，三碘甲状腺素和甲状腺素； 2）血液甘油三酸酯， 胆固醇和葡萄糖水平； 3）摄入高脂和高核物质的倾向； 4）在非繁殖男性，新父亲和经验丰富的父亲中，器官质量和脂肪储存的分布。根据实验1的结果，每组中一半的小鼠可能再次暴露于慢性，间歇性噪声压力源。预计这些研究将表明，加州疟原虫的父亲身份会改变代谢激素水平，能量稳态，代谢，身体组成和行为。他们还将阐明这些影响是如何通过父亲年龄/平等，后代年龄和慢性压力来调节的。结果将为哺乳动物父亲的生物学提供独特的见解，并最终可能会提高人们对父亲身份对男性健康和寿命的影响以及后代的健康成果的了解。