Established Investigator Award in Pediatric Cancer Epidemiology

设立儿童癌症流行病学研究者奖

基本信息

批准号：
8296484
负责人：
Julie Ann Ross
金额：
$ 13.95万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8296484
关键词：
Address Adult Animal Model Attention Award Biochemistry Biological Markers Birth Weight Blood Canada Cancer Etiology Cancer Research Network Case-Control Studies Cessation of life Child Childhood Childhood Leukemia Children&apos s Oncology Group Collaborations Collection Complement DNA Data Data Set Development Discipline Disease Dysmyelopoietic Syndromes Educational process of instructing Epidemiologic Studies Epidemiologist Epidemiology Etiology Faculty Folate Funding Future Gene Expression Genes Genetic Grant Hematopoietic Neoplasms Incidence Individual Infant Insulin-Like Growth Factor I Knowledge Malignant Childhood Neoplasm Malignant Neoplasms Measures Mentors Methods Methylation Modeling Molecular Molecular Epidemiology Mothers Mus Neonatal Screening Newborn Infant Newly Diagnosed Pathogenesis Patients Postdoctoral Fellow Questionnaires Registries Reporting Research Research Activity Research Personnel Resources Risk Risk Assessment Sampling Senior Scientist Award Specimen Spottings Students Supplementation Testing Time Training Umbilical Cord Blood United States United States National Institutes of Health Validation Vitamins Work age group aged anticancer research cancer epidemiology career cohort design epidemiology study fetal graduate student in utero innovation interest leukemia next generation novel population based programs research study tumor

项目摘要

DESCRIPTION (provided by applicant): Dr. Ross is internationally recognized for her work in pediatric cancer epidemiology. She has successfully developed several ancillary cross-disciplinary studies to augment epidemiological studies of childhood cancer. Further, as a natural progression of her research in childhood leukemia, she initiated two population-based molecular epidemiology studies of adult hematopoietic malignancies, anticipating that knowledge gained may be informative for all age groups. A K05 award will provide Dr. Ross protected research time (20% FTE) to pursue an innovative transdisciplinary approach toward understanding the etiology of childhood cancers. She plans to involve collaborators from other disciplines to address key questions. The overall outline of proposed research: 1) Application of murine models to augment etiological studies of childhood cancer; 2) Exploration of new initiatives utilizing biospecimens for potential future integration into childhood cancer studies; and 3) Expansion of analyses within existing research studies, including infant leukemia and other childhood malignancies, the Children's Oncology Group Childhood Cancer Research Network, and a new statewide study of myelodysplastic syndrome. Dr. Ross' proposed mentoring activities include enriching and expanding (20% FTE) her already wide-ranging mentoring of students (undergraduate, graduate, and post-doctoral) and junior faculty. She is program director of an NIH-funded training grant (T32) dedicated to training the next generation of pediatric cancer epidemiologists. In addition to serving on several master's and dissertation committees, Dr. Ross has served as primary research mentor to 15 graduate students, 8 postdocs, and 7 junior faculty. Her proposed mentoring pool during the K05 award period will include: 1) T32 trainees; 2) junior faculty developing careers in pediatric cancer research; and 3) at least three additional junior colleagues involved in K05-supported research activities. A K05 award will support both more concentrated and in-depth mentoring of future pediatric cancer researchers, as well as focus and stimulate new transdisciplinary research initiatives.

描述（由申请人提供）：Ross 博士因其在儿科癌症流行病学方面的工作而获得国际认可。她成功开展了多项辅助跨学科研究，以加强儿童癌症的流行病学研究。此外，作为儿童白血病研究的自然进展，她发起了两项针对成人造血系统恶性肿瘤的基于人群的分子流行病学研究，预计所获得的知识可能为所有年龄段的人提供信息。 K05 奖项将为 Ross 博士提供受保护的研究时间（20% FTE），以寻求创新的跨学科方法来了解儿童癌症的病因。她计划让其他学科的合作者参与来解决关键问题。拟议研究的总体轮廓：1）应用小鼠模型来增强儿童癌症的病因学研究； 2) 探索利用生物样本的新举措，以便将来可能融入儿童癌症研究； 3) 扩大现有研究范围内的分析，包括婴儿白血病和其他儿童恶性肿瘤、儿童肿瘤学组儿童癌症研究网络以及一项新的全州骨髓增生异常综合征研究。罗斯博士提议的指导活动包括丰富和扩展（20% FTE）她对学生（本科生、研究生和博士后）和初级教师的广泛指导。她是 NIH 资助的培训基金 (T32) 的项目主任，致力于培训下一代儿科癌症流行病学家。除了在多个硕士和论文委员会任职之外，罗斯博士还担任 15 名研究生、8 名博士后和 7 名初级教师的主要研究导师。她提议在 K05 奖励期间的指导池将包括： 1) T32 学员； 2) 初级教师在儿科癌症研究领域发展事业； 3) 至少另外三名初级同事参与 K05 支持的研究活动。 K05 奖将支持对未来儿科癌症研究人员进行更集中和深入的指导，并重点关注和刺激新的跨学科研究举措。