Neighborhood Characteristics & Diabetes Incidence in Multiethnic Cohort Study

街区特色

• 批准号: 8318230
• 负责人: KA'IMI ALOHILANI SINCLAIR
• 金额: $ 3.33万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318230
• 关键词: Address; Affect; African American; American; Area; Award; Behavior Therapy; Bioinformatics; Biomedical Research; Biometry; Cancer Burden; Cancer Center; Cancer Center Support Grant; Censuses; Characteristics; Cohort Studies; Complex; Computer-Assisted Image Analysis; Country; Data; Data Analyses; Data Set; Databases; Development; Diabetes Mellitus; Diabetes prevention; Diet; Dietary Practices; Dietary Questionnaires; Disadvantaged; Doctor of Philosophy; Economics; Education; Energy Intake; Environment; Environmental Risk Factor; Epidemic; Epidemiology; Ethnic Origin; Ethnic group; Faculty; Food; Food Supplements; Foundations; Funding; Future; Genetic Predisposition to Disease; Genome; Genomics; Geographic Information Systems; Goals; Hawaii; Hawaiian population; Health; Health Food; Health behavior; High Prevalence; Housing; Incidence; Individual; Individual Adjustment; Inequality; Instruction; Intervention; Japanese American; K-Series Research Career Programs; Laboratories; Latino; Life; Los Angeles; Malignant Neoplasms; Maps; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Minority; Mission; NCI Center for Cancer Research; NCI-Designated Cancer Center; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Operative Surgical Procedures; Participant; Pattern; Personal Satisfaction; Pharmaceutical Preparations; Physical activity; Physical environment; Population; Population Heterogeneity; Positioning Attribute; Prevalence; Principal Investigator; Public Health; Race; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Risk Factors; Role; SEER Program; Sampling; Services; Social Environment; Socioeconomic Status; Strategic Planning; Technology; Time; Training; Training Programs; Translating; United States National Institutes of Health; Universities; Wages; Work; base; career development; cohort; contextual factors; diabetes control; diabetes risk; diet and cancer; experience; geographic population; health disparity; health equity; low socioeconomic status; medical schools; member; multidisciplinary; multilevel analysis; neighborhood association; novel; nutrition; population based; population health; professor; programs; racial and ethnic; research facility; responsible research conduct; skills; social; socioeconomics; tumor registry

Candidate. The overarching goal of this Mentored Career Development Award (K01) is to provide Dr. Sinclair with the skills and experience to establish an independent program of diabetes-related disparities research. This career development award is grounded in a multilevel population health conceptual framework that merges advanced didactic instruction with individualized one-on-one mentorship. The advanced research training will serve to catalyze Dr. Sinclair's work, which focuses on unexplored contextual factors that contribute to diabetes prevalence and incidence. This award will provide her with time and salary support to develop an educational foundation and research program that broadens her capabilities to carry out multilevel health disparities research. To build this foundation, the training program consists of three core components: 1) formal coursework in epidemiology, biostatistics, Geographic Information Systems (GIS) technology, spatial analysis, and health disparities research, 2) mentored research training in multilevel modeling and GIS, and 3) instruction in the responsible conduct of research. Dr. Sinclair brings together an interdisciplinary mentorship board that offers extensive research experience and support of her career development program. The K01 award will allow her to benefit from a rich, multidisciplinary mentorship and training environment, which includes experts in epidemiology, biostatistics, GIS, diabetes, and health disparities research. Research Project. Dr. Sinclair proposes to empirically examine the spatial patterning and distribution of diabetes risk factors, prevalence and incidence among the Multiethnic Cohort Study participants by combining individual- and area-level data. The Multiethnic Cohort Study includes a diverse population-based sample of more than 100,000 Hawaiian residents, identified in 1993-1996, who have been followed for more than 15 years. In the proposed project, Dr. Sinclair will geocode the residential addresses of study participants at the time of entry into the cohort. Neighborhood socioeconomic status will be defined from the 1990 U.S. Census. Similarly, measures of neighborhood resources for physical activity and access to healthy foods will be defined. Research aims are to: 1) determine the cross-sectional association between neighborhood characteristics and the prevalence of diabetes and individual-level risk factors for diabetes, including obesity, poor diet, and low levels of physical activity, 2) assess the longitudinal association between neighborhood characteristics and the incidence of diabetes after adjustment for individual-level diabetes risk factors, and 3) examine if the association between neighborhood characteristics and diabetes prevalence and incidence differs by race and ethnicity. The use of a multilevel perspective can help to identify factors associated with diabetes-related disparities, and is congruent with the NIH strategic plan to move the country toward health equity. Findings from this study will illuminate the larger social and economic forces that create differences in health between neighborhoods, and identify geographical areas where traditional and novel public health interventions may best be targeted. The K01 award is critical to Dr. Sinclair's future as a diabetes researcher and will provide her with the time, mentorship, research skills, analytical training, and practical research experience to develop into an independently funded investigator in diabetes prevention and control among health disparate populations. Environment. The University of Hawaii at Mnoa is a major education and research facility that serves as the center for research and advanced graduate and professional studies. The UH School of Medicine houses the largest biomedical research facility in Hawaii, and is the most culturally and ethnically diverse medical school in the U.S. Housed within the medical school is the Department of Native Hawaiian Health where Dr. Sinclair is a member of the research faculty. Laurence N. Kolonel, MD, PhD, will serve as Dr. Sinclair's primary mentor. Dr. Kolonel is a Professor at the UH Cancer Research Center and Principal Investigator of the Multiethnic Cohort Study from which Dr. Sinclair will draw her research project. The Cancer Research Center is an NCI-designated cancer center and receives funding from a Cancer Center Support Grant. The Center's mission is to reduce the burden of cancer through research, education, and service with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawaii and the Pacific. There are currently three cohort studies in the Epidemiology Program, including the Multiethnic Cohort Study. A GIS workgroup, of which Dr. Sinclair is a member, was recently formed to examine contextual factors and cancer incidence. There are several shared resources of the Cancer Center including the Hawaii Tumor registry which is a member of NCI's SEER Program; biostatistics which provides support for study design and data analysis; nutrition support which provides expertise in dietary questionnaire development and maintains extensive food and supplement composition databases; an analytical laboratory capable of analyzing biospecimens and foods for a wide array of constituents; a genomics laboratory which supports studies of genetic susceptibilities and whole-genome expression; and a bioinformatics group which supports the management and analysis of large and complex datasets. While the research activities of the faculty are varied, they are thematically related to the focus on ethnic diversity.

候选人。这个指导的职业发展奖（K01）的总体目标是为辛克莱博士提供技能和经验，以建立与糖尿病相关差异研究的独立计划。该职业发展奖基于多层人群健康概念框架，该框架将高级教学教学与个性化的一对一指导合并。先进的研究培训将促进辛克莱博士的工作，该工作的重点是有助于糖尿病患病率和发病率的未开发的上下文因素。该奖项将为她提供时间和薪水支持 开发一个教育基金会和研究计划，扩大了她进行多层次健康差异研究的能力。为了建立这一基础，培训计划包括三个核心组成部分：1）流行病学，生物统计学，地理信息系统（GIS）技术，空间分析和健康差异研究的正式课程，2）指导多层建模和GIS的研究培训，以及3）指导研究负责研究的指导。辛克莱（Sinclair）博士汇集了一个跨学科指导委员会，该委员会提供了广泛的研究经验和对她的职业发展计划的支持。 K01奖将使她能够从丰富的，多学科的指导和培训环境中受益，这是她的 包括流行病学，生物统计学，GIS，糖尿病和健康差异研究专家。 研究项目。 Sinclair博士建议通过结合个体和区域级别的数据，从经验上检查糖尿病风险因素的空间模式和分布，多种族队列研究参与者之间的流行和发生率。多民族队列研究包括1993年至1996年确定的100,000多名夏威夷居民的不同基于人口的样本，这些样本已有15年以上。在拟议的项目中，Sinclair博士将在进入队列时地理编码研究参与者的住宅地址。邻里社会经济地位将从1990年的美国人口普查中定义。同样，将定义邻里资源的衡量标准和获得健康食品的机会。研究目的是：1）确定糖尿病和糖尿病的个人水平风险因素之间的横截面关联，包括肥胖，饮食不良和身体活动水平较低，2）评估糖尿病和糖尿病风险相关性的近距离事件的纵向关联，并检查糖尿病的发生率，并检查糖尿病的发生率，并检查个人水平的风险因素和3）。种族和种族有所不同。多层次观点的使用可以帮助识别与糖尿病相关差异相关的因素，并且与NIH战略计划一致，以使该国朝着卫生公平迈进。这项研究的发现将阐明更大的社会和经济力量，这些社会和经济力量在社区之间在健康之间造成差异，并确定最好针对传统和新型公共卫生干预措施的地理区域。 K01奖对于Sinclair博士作为糖尿病研究人员的未来至关重要，并将为她提供时间，指导，研究技能，分析培训和实践研究经验，以发展为预防糖尿病和控制的独立研究者 健康不同的人群。 环境。夏威夷大学MNOA是一家主要的教育和研究机构，是研究与高级研究生和专业研究中心。 UH医学院拥有夏威夷最大的生物医学研究机构，并且是医学院内所在的美国文化和种族多样性的医学院，是夏威夷卫生部，Sinclair博士是研究学院的成员。医学博士Laurence N. Kolonel将担任Sinclair博士的主要导师。 Kolonel博士是UH癌症研究中心的教授，也是多民族队列研究的首席研究员，Sinclair博士将从该研究中得出她的研究项目。癌症研究中心是NCI指定的癌症中心，并获得了癌症中心支持补助金的资金。该中心的使命是通过研究，教育和服务减轻癌症的负担，重点是夏威夷和太平洋的独特种族，文化和环境特征。目前，流行病学计划中有三项队列研究，包括多民族队列研究。最近成立了一个GIS工作组，其中辛克莱（Sinclair）是成员，以检查上下文因素和癌症的发病率。有 癌症中心的几个共享资源，包括夏威夷肿瘤注册中心，这是NCI SEER计划的成员；为研究设计和数据分析提供支持的生物统计学；提供饮食问卷开发的专业知识并维持广泛的食物和补充成分数据库的营养支持；一个分析实验室，能够分析各种成分的生物测量和食物；一个支持遗传敏感性和全基因组表达的研究的基因组学实验室。以及一个支持大型和复杂数据集的管理和分析的生物信息学组。尽管教师的研究活动各不相同，但它们在主题上与关注 种族多样性。