Neurogenic bladder dysfunctions in neurological disorders

神经系统疾病中的神经源性膀胱功能障碍

• 批准号: 8566213
• 负责人: Anna P Malykhina
• 金额: $ 33.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-29 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8566213
• 关键词: Adrenergic Agents; Adrenergic Agonists; Affect; Afferent Neurons; Agonist; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Animal Model; Animals; Area; Basic Science; Behavioral; Bladder; Bladder Dysfunction; Brain; Brain Stem; Cells; Cellular biology; Central Nervous System Diseases; Clinic; Clinical; Clinical Sciences; Confocal Microscopy; Data; Demyelinations; Development; Diagnosis; Disease; Disease remission; Encephalomyelitis; Etiology; Evaluation; Filament; Frequencies; Functional disorder; Image Analysis; Immunohistochemistry; Impairment; In Vitro; Incontinence; Increased frequency of micturition; Interdisciplinary Study; Laboratories; Lesion; Location; Lower urinary tract; Microbiology; Modeling; Motor; Multiple Sclerosis; Murine hepatitis virus; Mus; Muscarinics; Nature; Nerve Degeneration; Nervous system structure; Neural Pathways; Neuraxis; Neurodegenerative Disorders; Neurogenic Bladder; Neurology; Neurons; Neurosciences; Neurotransmitter Receptor; Nocturia; Overactive Bladder; Parkinson Disease; Pathology; Pathway interactions; Patient Education; Patients; Peripheral; Pharmacology; Phenotype; Philadelphia; Pontine structure; Quality Control; Research; Research Infrastructure; Research Personnel; Research Project Grants; Sensory; Severities; Smooth Muscle; Spinal Cord; Spinal Ganglia; Stream; Symptoms; System; Techniques; Testing; Tissues; United States; Urination; Urine; Urology; Visceral; adrenergic; animal tissue; awake; base; disability; functional disability; functional status; in vivo; lower urinary tract symptoms; meetings; micturition urgency; midbrain central gray substance; mouse model; nervous system disorder; neurophysiology; neuroregulation; novel therapeutics; programs; receptor internalization; research study; response; therapeutic development; translational approach; treatment strategy; urologic; young adult

Patients with neurological disorders such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis develop a wide range of lower urinary tract symptoms (LUTS) including urinary urgency, frequency, incontinence, nocturia. Neurogenic bladder dysfunctions observed in patients with neurological disorders usually result from damage to the peripheral and/or central nervous systems. The lack of understanding of pathophysiology and mechanisms underlying LUT dysfunctions in neurological disorders hampers the development of therapeutic strategies and treatment options for these patients. In response to the RFA-DK-12-003, we propose to form the Philadelphia Interdisciplinary Research Center on Neurogenic Bladder Dysfunctions. The primary focus of the Center will be on understanding the systemic and cellular mechanisms of neurogenic bladder dysfunctions resulting from degeneration in the CNS in order to clarify functional interplay between the urologic and nen/ous systems. The Philadelphia Center will: a) provide the intellectual infrastructure to tackle on projects that will become comprehensive programs determining the underlying etiology of LUTS in neurological disorders; b) establish a well-integrated interdisciplinary research team of clinical and basic science researchers in the Greater Philadelphia area which will focus the research efforts on LUTS using animal models of neurogenic bladder dysfunctions; c) extend the phenotyping of LUTS from animal models to patients diagnosed with neurological disorders and complaining of LUTS, and d) generate preliminary data necessary to submit a program project (POI) after completion of this study. The research team will include established investigators with diverse expertise in neurourology, neurophysiology, pharmacology, microbiology, neurodegeneration, and clinical neurology. The Philadelphia IR-BU Center W\\\ consist of: 1) the laboratories of key investigators and their collaborators that combine expertise in neurology, neurourology, neurophysiology, cellular biology, microbiology, neuroscience, pharmacology, and pathology; 2) an Administrative Core to provide administrative and fiscal oversight, quality control for the research, coordination of interactions among key investigators in the Center and organization of monthly meetings; 3) an Animal tissue core to provide tissues from mice with different levels of neurodegeneration and demyelination for basic research projects; 4) an Educational Enrichment Program to attract young investigators to the field of urology and support their research in the laboratories of key investigators.

患有多发性硬化症，帕金森氏病，阿尔茨海默氏病等神经系统疾病的患者 疾病，肌萎缩性侧索硬化症患有广泛的尿路症状（LUTS） 包括尿液紧急，频率，尿失禁，夜尿。在 神经系统疾病的患者通常是由于对周围和/或中枢神经的损害而造成的 系统。缺乏对病理生理学和LUT功能障碍的机制的理解 神经疾病阻碍了这些治疗策略和治疗选择的发展 患者。为了回应RFA-DK-12-003，我们建议组建费城跨学科 神经源性膀胱功能障碍研究中心。中心的主要重点将开始 了解由 中枢神经系统的变性是为了阐明泌尿科和NEN/OUS系统之间的功能相互作用。 费城中心将：a）提供智力基础设施来解决将成为的项目 确定神经系统疾病中LUTS的潜在病因的综合计划； b） 在临床和基础科学研究人员中建立一个良好的跨学科研究团队 大费城地区将使用动物模型将研究工作集中在LUTS上 神经源性膀胱功能障碍； c）将LUTS的表型从动物模型扩展到患者 诊断患有神经系统疾病和LUTS的抱怨，d）产生初步数据 本研究完成后必须提交计划项目（POI）。研究小组将包括 在神经病学，神经生理学，药理学， 微生物学，神经退行性和临床神经病学。费城IR-BU中心W \\\由：1） 关键研究人员及其合作者的实验室，结合了神经病学专业知识， 神经学，神经生理学，细胞生物学，微生物学，神经科学，药理学和药理学和 病理; 2）行政核心提供行政和财政监督，质量控制 研究，中心主要研究人员之间的互动和每月的组织 会议； 3）动物组织核心提供不同水平神经变性的小鼠的组织 和基础研究项目的脱髓鞘； 4）一个教育丰富计划，以吸引年轻人 泌尿外科领域的研究人员在主要研究人员的实验室中支持他们的研究。